KEGG   NETWORK: N01086
Entry
N01086                      Network                                

Name
Escherichia EspT to RAC signaling pathway
Definition
EspT -> RAC1 -> (WASF2+ABI1) -> ARP2/3 -> (ACTB,ACTG1)
  Expanded
K23651 -> 5879 -> (10163+10006) -> (10097+10096+10552+10095+10109+10094+10093+10092+81873) -> (60,71)
Class
nt06135 Cytoskeletal regulation (viruses and bacteria)
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
5879  RAC1; Rac family small GTPase 1
10163  WASF2; WASP family member 2
10006  ABI1; abl interactor 1
10097  ACTR2; actin related protein 2
10096  ACTR3; actin related protein 3
10552  ARPC1A; actin related protein 2/3 complex subunit 1A
10095  ARPC1B; actin related protein 2/3 complex subunit 1B
10109  ARPC2; actin related protein 2/3 complex subunit 2
10094  ARPC3; actin related protein 2/3 complex subunit 3
10093  ARPC4; actin related protein 2/3 complex subunit 4
10092  ARPC5; actin related protein 2/3 complex subunit 5
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like
60  ACTB; actin beta
71  ACTG1; actin gamma 1
Perturbant
K23651 (EspT)  espT; T3SS secreted effector EspT
Reference
  Authors
Bulgin R, Arbeloa A, Goulding D, Dougan G, Crepin VF, Raymond B, Frankel G
  Title
The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals.
  Journal
PLoS Pathog 5:e1000683 (2009)
DOI:10.1371/journal.ppat.1000683
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