| Entry |
|
|---|
| Name |
Salmonella SopE to RAC signaling pathway
|
|---|
| Definition |
SopE -> RAC1 -> (WASF+ABI1+HSPC300+CYFIP+NCKAP1) -> ARP2/3 -> (ACTB,ACTG1) |
|---|
| Expanded |
K13741 -> 5879 -> ((10163,10810,8936)+10006+55845+(23191,26999)+10787) -> (10097+10096+10552+10095+10109+10094+10093+10092+81873) -> (60,71) |
|---|
| Class |
|
|---|
| Type |
Pathogen
|
|---|
| Pathway |
|
|---|
| Disease |
|
|---|
| Gene |
| 5879 | RAC1; Rac family small GTPase 1 |
| 10163 | WASF2; WASP family member 2 |
| 10810 | WASF3; WASP family member 3 |
| 8936 | WASF1; WASP family member 1 |
| 10006 | ABI1; abl interactor 1 |
| 55845 | BRK1; BRICK1 subunit of SCAR/WAVE actin nucleating complex |
| 23191 | CYFIP1; cytoplasmic FMR1 interacting protein 1 |
| 26999 | CYFIP2; cytoplasmic FMR1 interacting protein 2 |
| 10787 | NCKAP1; NCK associated protein 1 |
| 10097 | ACTR2; actin related protein 2 |
| 10096 | ACTR3; actin related protein 3 |
| 10552 | ARPC1A; actin related protein 2/3 complex subunit 1A |
| 10095 | ARPC1B; actin related protein 2/3 complex subunit 1B |
| 10109 | ARPC2; actin related protein 2/3 complex subunit 2 |
| 10094 | ARPC3; actin related protein 2/3 complex subunit 3 |
| 10093 | ARPC4; actin related protein 2/3 complex subunit 4 |
| 10092 | ARPC5; actin related protein 2/3 complex subunit 5 |
| 81873 | ARPC5L; actin related protein 2/3 complex subunit 5 like |
|
|---|
| Perturbant |
| K13741 (SopE) | sopE; guanine nucleotide exchange factor SopE |
|
|---|
| Reference |
|
|---|
| Authors |
Humphreys D, Davidson A, Hume PJ, Koronakis V |
|---|
| Title |
Salmonella virulence effector SopE and Host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Friebel A, Ilchmann H, Aepfelbacher M, Ehrbar K, Machleidt W, Hardt WD |
|---|
| Title |
SopE and SopE2 from Salmonella typhimurium activate different sets of RhoGTPases of the host cell. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Van Acker T, Tavernier J, Peelman F |
|---|
| Title |
The Small GTPase Arf6: An Overview of Its Mechanisms of Action and of Its Role in Host(-)Pathogen Interactions and Innate Immunity. |
|---|
| Journal |
|
|---|
| LinkDB |
|
|---|
