KEGG   NETWORK: N01200
Entry
N01200                      Network                                
Name
Scrapie conformation PrPSc to transport of calcium
Definition
PRNP* -> NMDAR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> CASP3
  Expanded
5621v1 -> (2902+(2903,2904,2905,2906)) -> C00076 -- 90550 -> C00076 -- (7416,7417,7419,291,292,293,83447) -> 54205 == 317 -> 842 -> 836
Class
nt06465 Prion disease
nt06466 Pathways of neurodegeneration
Type
Variant
Pathway
hsa05020  Prion disease
Disease
H00061  Prion disease
Gene
5621  PRNP; prion protein
2902  GRIN1; glutamate ionotropic receptor NMDA type subunit 1
2903  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A
2904  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B
2905  GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C
2906  GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D
90550  MCU; mitochondrial calcium uniporter
7416  VDAC1; voltage dependent anion channel 1
7417  VDAC2; voltage dependent anion channel 2
7419  VDAC3; voltage dependent anion channel 3
291  SLC25A4; solute carrier family 25 member 4
292  SLC25A5; solute carrier family 25 member 5
293  SLC25A6; solute carrier family 25 member 6
83447  SLC25A31; solute carrier family 25 member 31
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Variant
5621v1 (PRNP*)  PRNP scrapie conformation
Metabolite
C00076  Calcium cation
C00076  Calcium cation
Reference
PMID:30710214
  Authors
Meneghetti E, Gasperini L, Virgilio T, Moda F, Tagliavini F, Benetti F, Legname G
  Title
Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases.
  Journal
Mol Neurobiol 56:6035-6045 (2019)
DOI:10.1007/s12035-019-1505-6
Reference
PMID:22310309
  Authors
Stys PK, You H, Zamponi GW
  Title
Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders.
  Journal
J Physiol 590:1357-68 (2012)
DOI:10.1113/jphysiol.2011.225276
Reference
PMID:27581199
  Authors
Peggion C, Bertoli A, Sorgato MC
  Title
Almost a century of prion protein(s): From pathology to physiology, and back to pathology.
  Journal
Biochem Biophys Res Commun 483:1148-1155 (2017)
DOI:10.1016/j.bbrc.2016.07.118
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