KEGG   NETWORK: N01354
Entry
N01354                      Network                                
Name
BPA to RAS-ERK signaling pathway
Definition
BPA -> EGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
C13624 -> 1956 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00031  Breast cancer
Gene
1956  EGFR; epidermal growth factor receptor
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Perturbant
C13624 (BPA)  Bisphenol A
Reference
  Authors
Murata M, Kang JH
  Title
Bisphenol A (BPA) and cell signaling pathways.
  Journal
Biotechnol Adv 36:311-327 (2018)
DOI:10.1016/j.biotechadv.2017.12.002
Reference
  Authors
Sauer SJ, Tarpley M, Shah I, Save AV, Lyerly HK, Patierno SR, Williams KP, Devi GR
  Title
Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells.
  Journal
Carcinogenesis 38:252-260 (2017)
DOI:10.1093/carcin/bgx003
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