KEGG   NETWORK: N01470
Entry
N01470                      Network                                
Name
Pre-IC formation
Definition
TOPBP1+RECQL4 == POLE == GINS -> ORC+CDC6+CDT1 == CDC45+MCM+GINS == POLE+TOPBP1+TICRR+MTBP+RECQL4
  Expanded
11073+9401 == 5426+5427+54107+56655 == 9837+51659+64785+84296 -> 4998+4999+23595+5000+5001+23594+990+81620 == 8318+4171+4172+4173+4174+4175+4176+9837+51659+64785+84296 == 5426+5427+54107+56655+11073+90381+27085+9401
Class
nt06509 DNA replication
Type
Reference
Pathway
hsa04110  Cell cycle
Gene
11073  TOPBP1; DNA topoisomerase II binding protein 1
9401  RECQL4; RecQ like helicase 4
5426  POLE; DNA polymerase epsilon, catalytic subunit
5427  POLE2; DNA polymerase epsilon 2, accessory subunit
54107  POLE3; DNA polymerase epsilon 3, accessory subunit
56655  POLE4; DNA polymerase epsilon 4, accessory subunit
9837  GINS1; GINS complex subunit 1
51659  GINS2; GINS complex subunit 2
64785  GINS3; GINS complex subunit 3
84296  GINS4; GINS complex subunit 4
4998  ORC1; origin recognition complex subunit 1
4999  ORC2; origin recognition complex subunit 2
23595  ORC3; origin recognition complex subunit 3
5000  ORC4; origin recognition complex subunit 4
5001  ORC5; origin recognition complex subunit 5
23594  ORC6; origin recognition complex subunit 6
990  CDC6; cell division cycle 6
81620  CDT1; chromatin licensing and DNA replication factor 1
8318  CDC45; cell division cycle 45
4171  MCM2; minichromosome maintenance complex component 2
4172  MCM3; minichromosome maintenance complex component 3
4173  MCM4; minichromosome maintenance complex component 4
4174  MCM5; minichromosome maintenance complex component 5
4175  MCM6; minichromosome maintenance complex component 6
4176  MCM7; minichromosome maintenance complex component 7
90381  TICRR; TOPBP1 interacting checkpoint and replication regulator
27085  MTBP; MDM2 binding protein
Reference
  Authors
Tanaka S, Ogawa S
  Title
Dimerization of Firing Factors for Replication Origin Activation in Eukaryotes: A Crucial Process for Simultaneous Assembly of Bidirectional Replication Forks?
  Journal
Biology (Basel) 11:928 (2022)
DOI:10.3390/biology11060928
Reference
  Authors
Gillespie PJ, Blow JJ
  Title
DDK: The Outsourced Kinase of Chromosome Maintenance.
  Journal
Biology (Basel) 11:877 (2022)
DOI:10.3390/biology11060877
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