KEGG   NETWORK: N01558
Entry
N01558                      Network                                
Name
Type I interferon to Jak-STAT signaling pathway
Definition
(IFNA,IFNB1,IFNW1,IFNK,IFNE) -> (IFNAR1+IFNAR2) -> (JAK1+TYK2) -> (STAT1+STAT2) == IRF9
  Expanded
((3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452),3456,3467,56832,338376) -> (3454+3455) -> (3716+7297) -> (6772+6773) == 10379
Class
nt06518 JAK-STAT signaling
Type
Reference
Pathway
hsa04630  JAK-STAT signaling pathway
Gene
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
3467  IFNW1; interferon omega 1
56832  IFNK; interferon kappa
338376  IFNE; interferon epsilon
3454  IFNAR1; interferon alpha and beta receptor subunit 1
3455  IFNAR2; interferon alpha and beta receptor subunit 2
3716  JAK1; Janus kinase 1
7297  TYK2; tyrosine kinase 2
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
10379  IRF9; interferon regulatory factor 9
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
LinkDB

DBGET integrated database retrieval system