KEGG   NETWORK: N01559
Entry
N01559                      Network                                
Name
Type II interferon to Jak-STAT signaling pathway
Definition
IFNG -> (IFNGR1,IFNGR2) -> (JAK1+JAK2) -> (STAT1,STAT3) => (IL27,IFNA,IFNG)
  Expanded
3458 -> (3459,3460) -> (3716+3717) -> (6772,6774) => (246778,(3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452),3458)
Class
nt06518 JAK-STAT signaling
Type
Reference
Pathway
hsa04630  JAK-STAT signaling pathway
Gene
3458  IFNG; interferon gamma
3459  IFNGR1; interferon gamma receptor 1
3460  IFNGR2; interferon gamma receptor 2
3716  JAK1; Janus kinase 1
3717  JAK2; Janus kinase 2
6772  STAT1; signal transducer and activator of transcription 1
6774  STAT3; signal transducer and activator of transcription 3
246778  IL27; interleukin 27
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
Reference
PMID:31842362
  Authors
Owen KL, Brockwell NK, Parker BS
  Title
JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression.
  Journal
Cancers (Basel) 11:E2002 (2019)
DOI:10.3390/cancers11122002
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
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