KEGG   NETWORK: N01579
Entry
N01579                      Network                                
Name
CD80/CD86-CTLA4-PP2A signaling pathway
Definition
(CD80,CD86) -> CTLA4 -> PP2A -| AKT
  Expanded
(941,942) -> 1493 -> ((5515,5516)+(5518,5519)+(5520,5521,5522,55844,5523,28227,55012,5525,5526,5527,5528,5529)) -| (207,208,10000)
Class
nt06537 TCR/BCR signaling
Type
Reference
Pathway
hsa04660  T cell receptor signaling pathway
Gene
941  CD80; CD80 molecule
942  CD86; CD86 molecule
1493  CTLA4; cytotoxic T-lymphocyte associated protein 4
5515  PPP2CA; protein phosphatase 2 catalytic subunit alpha
5516  PPP2CB; protein phosphatase 2 catalytic subunit beta
5518  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha
5519  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta
5520  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha
5521  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta
5522  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma
55844  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta
5523  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha
28227  PPP2R3B; protein phosphatase 2 regulatory subunit B''beta
55012  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma
5525  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha
5526  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta
5527  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma
5528  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta
5529  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Reference
PMID:35950451
  Authors
Kim GR, Choi JM
  Title
Current Understanding of Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) Signaling in T-Cell Biology and Disease Therapy.
  Journal
Mol Cells 45:513-521 (2022)
DOI:10.14348/molcells.2022.2056
Reference
PMID:33613563
  Authors
McBride MA, Patil TK, Bohannon JK, Hernandez A, Sherwood ER, Patil NK
  Title
Immune Checkpoints: Novel Therapeutic Targets to Attenuate Sepsis-Induced Immunosuppression.
  Journal
Front Immunol 11:624272 (2020)
DOI:10.3389/fimmu.2020.624272
Reference
PMID:23851140
  Authors
Romo-Tena J, Gomez-Martin D, Alcocer-Varela J
  Title
CTLA-4 and autoimmunity: new insights into the dual regulator of tolerance.
  Journal
Autoimmun Rev 12:1171-6 (2013)
DOI:10.1016/j.autrev.2013.07.002
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