Entry
Name
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating);
pyruvate dehydrogenase complex
Definition
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
Equation
Comment
Reaction class
Enzyme
Pathway
rn01110 Biosynthesis of secondary metabolites
rn01120 Microbial metabolism in diverse environments
rn01210 2-Oxocarboxylic acid metabolism
Module
M00307 Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
Enzymatic reactions [BR:br08201 ]
1. Oxidoreductase reactions
1.2 Acting on the aldehyde or oxo group of donors
1.2.1 With NAD+ or NADP+ as acceptor
1.2.1.104
R00209 Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
BRITE hierarchy
Orthology
K00161 pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1 ]
K00162 pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1 ]
K00627 pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12 ]
Other DBs
LinkDB
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