KEGG   REACTION: R01934
Entry
R01934                      Reaction                               
Name
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating);
homoisocitrate:NAD+ oxidoreductase (decarboxylating)
Definition
Homoisocitrate + NAD+ <=> 2-Oxoadipate + CO2 + NADH + H+
Equation
C05662 + C00003 <=> C00322 + C00011 + C00004 + C00080
Comment
two-step reaction (see R04862+R01936), reversible
Reaction class
RC00001  C00003_C00004
RC00114  C00322_C05662
Enzyme
1.1.1.87        1.1.1.286
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.87
     R01934  Homoisocitrate + NAD+ <=> 2-Oxoadipate + CO2 + NADH + H+
    1.1.1.286
     R01934  Homoisocitrate + NAD+ <=> 2-Oxoadipate + CO2 + NADH + H+
Orthology
K05824  homoisocitrate dehydrogenase [EC:1.1.1.87]
K10978  methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Reference
1  [PMID:4395693]
  Authors
Rowley B, Tucci AF
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
Reference
2  [PMID:5808337]
  Authors
Chilina K, Thomas U, Tucci AF, McMichael KD, Stevens CM.
  Title
Synthesis and absolute configuration of the isomers of homoisocitric acid (1-hydroxy-1,2,4-butanetricarboxylic acid) and the stereochemistry of lysine biosynthesis.
  Journal
Biochemistry 8:2846-55 (1969)
DOI:10.1021/bi00835a023
Other DBs
RHEA: 11903
LinkDB

KEGG   REACTION: R04862
Entry
R04862                      Reaction                               
Name
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
Definition
Homoisocitrate + NAD+ <=> Oxaloglutarate + NADH + H+
Equation
C05662 + C00003 <=> C05533 + C00004 + C00080
Comment
the first step of two-step reaction (see R01934, R04862+R01936)
subsequently R01936
Reaction class
RC00001  C00003_C00004
RC00084  C05533_C05662
Enzyme
1.1.1.87        1.1.1.286
Pathway
rn01210  2-Oxocarboxylic acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.87
     R04862  Homoisocitrate + NAD+ <=> Oxaloglutarate + NADH + H+
    1.1.1.286
     R04862  Homoisocitrate + NAD+ <=> Oxaloglutarate + NADH + H+
Orthology
K05824  homoisocitrate dehydrogenase [EC:1.1.1.87]
K10978  methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
LinkDB

KEGG   REACTION: R01936
Entry
R01936                      Reaction                               
Name
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
Definition
Oxaloglutarate <=> 2-Oxoadipate + CO2
Equation
C05533 <=> C00322 + C00011
Comment
the second step of two-step reaction (see R01934, R04862+R01936)
following after R04862
Reaction class
RC00626  C00322_C05533
Enzyme
1.1.1.87        1.1.1.286
Pathway
rn01210  2-Oxocarboxylic acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.87
     R01936  Oxaloglutarate <=> 2-Oxoadipate + CO2
    1.1.1.286
     R01936  Oxaloglutarate <=> 2-Oxoadipate + CO2
Orthology
K05824  homoisocitrate dehydrogenase [EC:1.1.1.87]
K10978  methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
LinkDB

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