KEGG   REACTION: R04225
Entry
R04225                      Reaction                               
Name
(S)-3-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
Definition
(S)-3-Methyl-2-oxopentanoic acid + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2
Equation
C00671 + C15972 <=> C15979 + C00011
Comment
3-methyl-2-oxobutanoate dehydrogenase complexes:3-methyl-2-oxobutanoate dehydrogenase
a part of multi-step reaction (see R04225+R03174+R07618, possibly identical to R03171)
subsequently R03174
TPP-dependent enzyme (see R07603+R07604)
Reaction class
RC00627  C15972_C15979
RC02856  C00671_C15979
Enzyme
1.2.4.4
Pathway
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.4
     R04225  (S)-3-Methyl-2-oxopentanoic acid + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2
Orthology
K00166  2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
LinkDB

KEGG   REACTION: R03174
Entry
R03174                      Reaction                               
Name
(S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase
Definition
(S)-2-Methylbutanoyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
Equation
C15980 + C15973 <=> C00010 + C15979
Comment
3-methyl-2-oxobutanoate dehydrogenase complexes:3-methyl-2-oxobutanoate dehydrogenase
a part of multi-step reaction (see R04225+R03174+R07618, possibly identical to R03171)
following after R04225
Reaction class
RC00004  C00010_C15980  C15973_C15979
RC02870  C15979_C15980
Enzyme
2.3.1.168
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00785  Lipoic acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.168
     R03174  (S)-2-Methylbutanoyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
Orthology
K09699  2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168]
LinkDB

KEGG   REACTION: R07618
Entry
R07618                      Reaction                               
Name
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Definition
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
Equation
C15973 + C00003 <=> C15972 + C00004 + C00080
Comment
Oxo-acid dehydrogenase complexes, dihydrolipoyl dehydrogenase
Reaction class
RC00001  C00003_C00004
RC00583  C15972_C15973
Enzyme
1.8.1.4
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00310  Lysine degradation
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
rn00785  Lipoic acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.8  Acting on a sulfur group of donors
   1.8.1  With NAD+ or NADP+ as acceptor
    1.8.1.4
     R07618  Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.8.1.4
   R08550  [Protein]-N6-[(R)-dihydrolipoyl]-L-lysine <=> Protein N6-(lipoyl)lysine
    R07618  Enzyme N6-(dihydrolipoyl)lysine <=> Enzyme N6-(lipoyl)lysine
Orthology
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
Other DBs
RHEA: 15048
LinkDB

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