KEGG   REACTION: R07048
Entry
R07048                      Reaction                               
Definition
Arachidonate + Oxygen + NADPH + H+ <=> 14,15-EET + NADP+ + H2O
Equation
C00219 + C00007 + C00005 + C00080 <=> C14771 + C00006 + C00001
Comment
CYP2C8/9/10/11/23/34/40, CYP2B, CYP2J2/4
Reaction class
RC00001  C00005_C00006
RC01711  C00219_C14771
Enzyme
1.14.14.1       1.14.14.-
Pathway
rn00590  Arachidonic acid metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1
     R07048  Arachidonate + Oxygen + NADPH + H+ <=> 14,15-EET + NADP+ + H2O
    1.14.14.-
     R07048  Arachidonate + Oxygen + NADPH + H+ <=> 14,15-EET + NADP+ + H2O
Orthology
K07412  cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
K07413  cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
K07418  cytochrome P450 family 2 subfamily J [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
K17709  cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
K17718  cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
K17719  cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
Reference
1  [PMID:23362865]
  Authors
Knights KM, Rowland A, Miners JO.
  Title
Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).
  Journal
Br J Clin Pharmacol 76:587-602 (2013)
DOI:10.1111/bcp.12086
Reference
2  [PMID:11679404]
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
3  [PMID:10908295]
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
LinkDB

KEGG   RCLASS: RC01711
Entry
RC01711                     RClass                                 
Definition
C1y-C2b:O2x-*:C1b+C1y-C1b+C2b
C1y-C2b:O2x-*:C1b+C1y-C1b+C2b
Reactant pair
C00219_C14768    C00219_C14769    C00219_C14770
C00219_C14771    C00712_C19418    C01595_C14825
C01595_C14826    C19616_C19620
Related class
Reaction
R07048 R07050 R07051 R07052 R07055 R07056 R09462 R09463
Enzyme
1.11.2.3        1.14.14.1       1.14.14.-
Pathway
rn00073  Cutin, suberine and wax biosynthesis
rn00590  Arachidonic acid metabolism
rn00591  Linoleic acid metabolism
rn01100  Metabolic pathways
Orthology
K07409  cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K07412  cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
K07413  cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
K07415  cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]
K07418  cytochrome P450 family 2 subfamily J [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
K07424  cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
K07425  long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
K17689  cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
K17709  cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
K17718  cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
K17719  cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
K17721  cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
K17991  peroxygenase [EC:1.11.2.3]

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