KEGG ORTHOLOGY: K07415

ORTHOLOGY: K07415

Entry

K07415                      KO

Symbol

CYP2E1

Name

cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]

Pathway

map00140

Steroid hormone biosynthesis

map00590

Arachidonic acid metabolism

map00591

Linoleic acid metabolism

map00980

Metabolism of xenobiotics by cytochrome P450

map00982

Drug metabolism - cytochrome P450

map00983

Drug metabolism - other enzymes

map01100

Metabolic pathways

map04932

Non-alcoholic fatty liver disease

map04936

Alcoholic liver disease

map05204

Chemical carcinogenesis - DNA adducts

map05208

Chemical carcinogenesis - reactive oxygen species

Reaction

R03408

R07000

naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07001

naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07021

1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07022

1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07046

R07055

R07056

R07066

bromobenzene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07068

bromobenzene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07075

4-bromophenol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07088

1,1-dichloroethylene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07089

1,1-dichloroethylene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07090

1,1-dichloroethylene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07098

trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07099

trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07107

trichloroethanol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07112

1,2-dibromoethane,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R08303

R08304

R09421

R11904

acetylhydrazine,NADPH:oxygen oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00590 Arachidonic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00591 Linoleic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00982 Drug metabolism - cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00983 Drug metabolism - other enzymes
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   04932 Non-alcoholic fatty liver disease
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP2 family
   K07415  CYP2E1; cytochrome P450 family 2 subfamily E1

Genes

HSA:	1571(CYP2E1)

PTR:	450857(CYP2E1)

PPS:	100981327(CYP2E1)

GGO:

101151246

PON:	100173813(CYP2E1)

PPYG:

NLE:

HMH:

SSYN:

MCC:	114669719 114669866 678688(CYP2E1)

MCF:	102136686(CYP2E1) 135965219

MTHB:

126963293 126963295

MNI:

105471354

CSAB:

103245979(CYP2E1)

CATY:

105598973 105599024

TGE:	112631352 112631637

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100397922(CYP2E1)

SBQ:

101046377

CIMI:

108297222(CYP2E1)

ANAN:

105732195(CYP2E1)

CSYR:

103265545

MMUR:

105861495

LCAT:

123649856

ERUF:

138376314(CYP2E1)

PCOQ:

105823486

OGA:

100958050

MMU:	13106(Cyp2e1)

MCAL:

110297258

MPAH:

110329381

RNO:	25086(Cyp2e1)

MCOC:

ANU:

ASYL:

MUN:

CGE:

MAUA:

PROB:

PLEU:

PMAV:

102924223(Cyp2e1)

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

105998603 106000254 106001755

DSP:	122095015 122095017 122127841

DMER:

138813020 138813022 138813023 138818555 138818657 138818813 138819818 138822588

PLOP:

125345916 125362239(Bet1l) 125364785

NCAR:

124974930

MMMA:

107152888

ITI:

101973029

OCU:	100342322 100342572

OPI:

OCZ:

TUP:

GVR:

CFA:	415128(CYP2E1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:	110583667 110587118

LWW:

102726765

FCA:	554227(CYP2E1) 554344(CYP2E1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:

BTA:	282213(CYP2E1)

BOM:	102281471(CYP2E1)

BIU:

BBUB:

BBIS:

CHX:

OAS:	100568285(CYP2E1)

BTAX:

128067945

CSUM:

138070195(CYP2E1)

ODA:

120873945

CCAD:

122446540

MREE:

136158385(CYP2E1)

OVR:	110128951(CYP2E1)

MBEZ:

129555934

SSC:	403216(CYP2E1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

GMF:	115839785(CYP2E1)

DDP:	132439501(CYP2E1)

DLE:

111172152

PCAD:

102993260

PSIU:

116741596

PPHC:

136136360(CYP2E1)

NASI:

112411197

ECB:	100066422(CYP2E1)

EPZ:	103556383(CYP2E1)

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

MYUM:

139021414(CYP2E1)

PKL:

EFUS:

DRO:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

TOD:

SFUM:

SETR:

TMU:	101343596 101344375

ETF:

DNM:

MDO:

GAS:

AFZ:	127546978 127546992

PCW:

110214053

TVP:

118829200

PBRV:

138148560

MLAO:

141520796(CYP2E1)

OAA:

TACU:

PFLL:

ABRU:

MMER:

Reference

PMID:3782137

Authors

Song BJ, Gelboin HV, Park SS, Yang CS, Gonzalez FJ

Title

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

Journal

J Biol Chem 261:16689-97 (1986)

Sequence

[hsa:1571]

LinkDB

DBGET integrated database retrieval system