KEGG   REACTION: R08332
Entry
R08332                      Reaction                               
Name
acetyl-CoA:2-oxopimelate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
Definition
2-Oxopimelate + Acetyl-CoA + H2O <=> (R)-(Homo)3-citrate + CoA
Equation
C16588 + C00024 + C00001 <=> C16598 + C00010
Reaction class
RC00004  C00010_C00024
RC00067  C16588_C16598
Enzyme
2.3.3.-
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01240  Biosynthesis of cofactors
Module
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.-
     R08332  2-Oxopimelate + Acetyl-CoA + H2O <=> (R)-(Homo)3-citrate + CoA
Orthology
K10977  methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]
Reference
1  [PMID:10940051]
  Authors
Howell DM, Graupner M, Xu H, White RH
  Title
Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea.
  Journal
J Bacteriol 182:5013-6 (2000)
DOI:10.1128/JB.182.17.5013-5016.2000
Other DBs
RHEA: 44931
LinkDB

KEGG   RCLASS: RC00067
Entry
RC00067                     RClass                                 
Definition
C1d-C5a:C1b-*:C1b+C6a+O1a-C1b+C6a+O5a
Reactant pair
C00026_C01251    C00036_C00158    C00036_C00566
C00036_C04115    C00109_C02488    C00166_C20653
C00322_C16583    C01180_C17210    C02798_C21613
C05994_C06255    C06368_C17947    C16588_C16598
C17211_C17214    C17216_C17218    C17220_C17222
C17224_C17226    C17228_C17230
Related class
Reaction
R00271 R00350 R00351 R00352 R00354 R00362 R00998 R05063
R08331 R08332 R08619 R08623 R08627 R08631 R08640 R08644
R08870 R10500 R11708
Enzyme
2.3.3.1         2.3.3.3         2.3.3.5         2.3.3.6         
2.3.3.8         2.3.3.14        2.3.3.16        2.3.3.17        
2.3.3.18        2.3.3.19        2.3.3.-         4.1.3.6         
4.1.3.17        4.1.3.34        4.1.3.-
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00300  Lysine biosynthesis
rn00362  Benzoate degradation
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00440  Phosphonate and phosphinate metabolism
rn00630  Glyoxylate and dicarboxylate metabolism
rn00680  Methane metabolism
rn00720  Other carbon fixation pathways
rn00966  Glucosinolate biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
RModule
RM001  2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
Orthology
K01643  citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10]
K01644  citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34]
K01646  citrate lyase subunit gamma (acyl carrier protein)
K01647  citrate synthase [EC:2.3.3.1]
K01648  ATP citrate (pro-S)-lyase [EC:2.3.3.8]
K01655  homocitrate synthase [EC:2.3.3.14]
K01659  2-methylcitrate synthase [EC:2.3.3.5]
K02594  homocitrate synthase NifV [EC:2.3.3.14]
K05942  citrate (Re)-synthase [EC:2.3.3.3]
K10218  4-hydroxy-4-methyl-2-oxoglutarate aldolase [EC:4.1.3.17]
K10977  methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]
K12910  2-phosphinomethylmalate synthase [EC:2.3.3.18]
K15230  ATP-citrate lyase alpha-subunit [EC:2.3.3.8]
K15231  ATP-citrate lyase beta-subunit [EC:2.3.3.8]
K15234  citryl-CoA lyase [EC:4.1.3.34]
K15741  methylthioalkylmalate synthase 1 [EC:2.3.3.17]
K15742  methylthioalkylmalate synthase 3 [EC:2.3.3.17]
K17748  benzylmalate synthase [EC:2.3.3.-]
K21934  2-phosphonomethylmalate synthase [EC:2.3.3.19]
K27797  2-methylcitrate synthase [EC:2.3.3.5]

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