KEGG   PATHWAY: actn00260
Entry
actn00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Actinoplanes sp. N902-109
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
actn00260  Glycine, serine and threonine metabolism
actn00260

Module
actn_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:actn00260]
actn_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:actn00260]
actn_M00621  Glycine cleavage system [PATH:actn00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Actinoplanes sp. N902-109 [GN:actn]
Gene
L083_0523  [KO:K00831] [EC:2.6.1.52]
L083_0707  glyA; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
L083_1029  pssA; CDP-alcohol phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
L083_1111  cysM; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
L083_1127  [KO:K01754] [EC:4.3.1.19]
L083_1408  serA; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
L083_1825  tdcB; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
L083_1832  [KO:K00133] [EC:1.2.1.11]
L083_1864  [KO:K00382] [EC:1.8.1.4]
L083_1867  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
L083_1884  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
L083_1940  [KO:K01620] [EC:4.1.2.48]
L083_2087  trpB; indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
L083_2088  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
L083_2558  [KO:K01754] [EC:4.3.1.19]
L083_3311  [KO:K00276] [EC:1.4.3.21]
L083_3407  [KO:K01834] [EC:5.4.2.11]
L083_3882  [KO:K00273] [EC:1.4.3.3]
L083_4003  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
L083_4026  gcvH; glycine cleavage system H protein [KO:K02437]
L083_4085  [KO:K00301] [EC:1.5.3.1]
L083_4087  [KO:K00309]
L083_4149  [KO:K01733] [EC:4.2.3.1]
L083_4211  msmA; aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
L083_4283  [KO:K00274] [EC:1.4.3.4]
L083_4502  [KO:K01733] [EC:4.2.3.1]
L083_4576  [KO:K01695] [EC:4.2.1.20]
L083_4577  [KO:K01696] [EC:4.2.1.20]
L083_4622  [KO:K00928] [EC:2.7.2.4]
L083_4623  asd1; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
L083_4798  aao; D-aspartate oxidase [KO:K00273] [EC:1.4.3.3]
L083_4810  [KO:K00273] [EC:1.4.3.3]
L083_5454  tynA; copper amine oxidase [KO:K00276] [EC:1.4.3.21]
L083_6299  [KO:K25316]
L083_6588  ltaA; L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
L083_6927  [KO:K01758] [EC:4.4.1.1]
L083_6964  [KO:K00058] [EC:1.1.1.95 1.1.1.399]
L083_7070  [KO:K00600] [EC:2.1.2.1]
L083_7085  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
L083_7090  [KO:K01733] [EC:4.2.3.1]
L083_7091  [KO:K00003] [EC:1.1.1.3]
L083_7665  gpmA; phosphoglycerate mutase 1 family [KO:K01834] [EC:5.4.2.11]
L083_7789  [KO:K01733] [EC:4.2.3.1]
L083_7922  ask; aspartate kinase [KO:K00928] [EC:2.7.2.4]
L083_7923  asd2; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
C23135  (2S,3S)-2-Acetamido-3-hydroxy-4-aminobutyrate
C23136  4-Amino-L-allothreonine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
actn00010  Glycolysis / Gluconeogenesis
actn00020  Citrate cycle (TCA cycle)
actn00230  Purine metabolism
actn00250  Alanine, aspartate and glutamate metabolism
actn00270  Cysteine and methionine metabolism
actn00290  Valine, leucine and isoleucine biosynthesis
actn00300  Lysine biosynthesis
actn00330  Arginine and proline metabolism
actn00460  Cyanoamino acid metabolism
actn00470  D-Amino acid metabolism
actn00564  Glycerophospholipid metabolism
actn00600  Sphingolipid metabolism
actn00620  Pyruvate metabolism
actn00630  Glyoxylate and dicarboxylate metabolism
actn00640  Propanoate metabolism
actn00680  Methane metabolism
actn00860  Porphyrin metabolism
actn00920  Sulfur metabolism
KO pathway
ko00260   

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