KEGG   PATHWAY: bbut04980
Entry
bbut04980                   Pathway                                
Name
Cobalamin transport and metabolism - Buteo buteo (common buzzard)
Class
Organismal Systems; Digestive system
Pathway map
bbut04980  Cobalamin transport and metabolism
bbut04980

Organism
Buteo buteo (common buzzard) [GN:bbut]
Gene
142025800  HCFC1; host cell factor 1 [KO:K14966]
142031488  MMADHC; cobalamin trafficking protein CblD isoform X1 [KO:K26006]
142032079  ABCD4; lysosomal cobalamin transporter ABCD4 isoform X1 [KO:K05678] [EC:7.6.2.8]
142034354  MMAA; methylmalonic aciduria type A protein, mitochondrial [KO:K07588] [EC:3.6.5.-]
142035166  MMACHC; cyanocobalamin reductase / alkylcobalamin dealkylase isoform X1 [KO:K14618] [EC:1.16.1.6 2.5.1.151]
142035167  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
142036839  THAP11; THAP domain-containing protein 11 [KO:K23211]
142037136  MMAB; corrinoid adenosyltransferase MMAB [KO:K00798] [EC:2.5.1.17]
142037460  TCN2; transcobalamin-2 [KO:K14619]
142038128  MTR; methionine synthase isoform X1 [KO:K00548] [EC:2.1.1.13]
142039677  LMBRD1; lysosomal cobalamin transport escort protein LMBD1 isoform X1 [KO:K14617]
142039986  CBLIF; cobalamin binding intrinsic factor [KO:K14615]
142040323  ZNF143; zinc finger protein 143 isoform X1 [KO:K20828]
142040764  MMUT; methylmalonyl-CoA mutase, mitochondrial [KO:K01847] [EC:5.4.99.2]
142042403  MTRR; methionine synthase reductase [KO:K00597] [EC:1.16.1.8]
142043680  ZNF76; zinc finger protein 76 isoform X1 [KO:K20828]
Compound
C00073  L-Methionine
C00091  Succinyl-CoA
C00101  Tetrahydrofolate
C00155  L-Homocysteine
C00194  Cobamide coenzyme
C00440  5-Methyltetrahydrofolate
C00541  Cob(II)alamin
C01213  (R)-Methylmalonyl-CoA
C02823  Cyanocobalamin
C06409  [Methionine synthase]-cob(II)alamin
C06410  [Methionine synthase]-methylcob(III)alamin
C06453  Methylcobalamin
C08230  Hydroxocobalamin
C22880  [Methionine synthase]-cob(I)alamin
Reference
PMID:35337617
  Authors
Nijland M, Martinez Felices JM, Slotboom DJ, Thangaratnarajah C
  Title
Membrane transport of cobalamin.
  Journal
Vitam Horm 119:121-148 (2022)
DOI:10.1016/bs.vh.2022.01.008
Reference
PMID:35337623
  Authors
Hannibal L, Jacobsen DW
  Title
Intracellular processing of vitamin B(12) by MMACHC (CblC).
  Journal
Vitam Horm 119:275-298 (2022)
DOI:10.1016/bs.vh.2022.02.001
Reference
PMID:35337626
  Authors
Watkins D, Rosenblatt DS
  Title
Inherited defects of cobalamin metabolism.
  Journal
Vitam Horm 119:355-376 (2022)
DOI:10.1016/bs.vh.2022.01.010
Reference
PMID:36422244
  Authors
Kosa M, Galla Z, Lenart I, Barath A, Grecso N, Racz G, Bereczki C, Monostori P
  Title
Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency  Detected by Newborn Screening.
  Journal
Metabolites 12:metabo12111104 (2022)
DOI:10.3390/metabo12111104
Reference
PMID:20301503
  Authors
Sloan JL, Carrillo N, Adams D, Venditti CP
  Title
Disorders of Intracellular Cobalamin Metabolism.
  Journal
GeneReviews (1993)
Reference
PMID:23539619
  Authors
Gherasim C, Lofgren M, Banerjee R
  Title
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin.
  Journal
J Biol Chem 288:13186-93 (2013)
DOI:10.1074/jbc.R113.458810
Related
pathway
bbut00270  Cysteine and methionine metabolism
bbut00280  Valine, leucine and isoleucine degradation
bbut00670  One carbon pool by folate
bbut04144  Endocytosis
bbut04977  Vitamin digestion and absorption
KO pathway
ko04980   

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