KEGG   PATHWAY: bel00260
Entry
bel00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bradyrhizobium elkanii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bel00260  Glycine, serine and threonine metabolism
bel00260

Module
bel_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bel00260]
bel_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bel00260]
bel_M00621  Glycine cleavage system [PATH:bel00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bradyrhizobium elkanii [GN:bel]
Gene
BE61_44710  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BE61_11470  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
BE61_57950  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BE61_06130  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BE61_59180  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BE61_88680  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
BE61_54980  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BE61_05070  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BE61_15760  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BE61_43110  ltaE; threonine aldolase [KO:K01620] [EC:4.1.2.48]
BE61_50860  glyA; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BE61_54570  glyA; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BE61_79470  glyA; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BE61_04840  serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BE61_39880  serine-glyoxylate aminotransferase SgaA [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BE61_39900  serine-glyoxylate aminotransferase SgaA [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BE61_86190  2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BE61_66160  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
BE61_14450  ttuD; hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
BE61_08310  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BE61_57110  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BE61_68120  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BE61_71260  glycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BE61_75860  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BE61_24570  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BE61_24750  2-ketogluconate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BE61_29310  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BE61_33880  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BE61_36580  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BE61_24560  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BE61_36900  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
BE61_15920  hemA; 5-aminolevulinic acid synthase [KO:K00643] [EC:2.3.1.37]
BE61_75370  hypothetical protein [KO:K00274] [EC:1.4.3.4]
BE61_06690  aofH; monoamine oxidase [KO:K00274] [EC:1.4.3.4]
BE61_66890  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
BE61_42570  gcvP; glycine cleavage system protein P2 [KO:K00281] [EC:1.4.4.2]
BE61_42590  gcvT; glycine cleavage system component T [KO:K00605] [EC:2.1.2.10]
BE61_54970  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BE61_05580  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BE61_42580  gcvH; glycine cleavage system component H [KO:K02437]
BE61_64110  pssA; phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
BE61_01730  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
BE61_87610  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
BE61_41130  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BE61_66240  hypothetical protein [KO:K01754] [EC:4.3.1.19]
BE61_10210  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BE61_33770  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BE61_36930  ilvA; amino-acid dehydratase [KO:K01754] [EC:4.3.1.19]
BE61_09080  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
BE61_09070  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bel00010  Glycolysis / Gluconeogenesis
bel00020  Citrate cycle (TCA cycle)
bel00230  Purine metabolism
bel00250  Alanine, aspartate and glutamate metabolism
bel00270  Cysteine and methionine metabolism
bel00290  Valine, leucine and isoleucine biosynthesis
bel00300  Lysine biosynthesis
bel00330  Arginine and proline metabolism
bel00460  Cyanoamino acid metabolism
bel00470  D-Amino acid metabolism
bel00564  Glycerophospholipid metabolism
bel00620  Pyruvate metabolism
bel00630  Glyoxylate and dicarboxylate metabolism
bel00640  Propanoate metabolism
bel00680  Methane metabolism
bel00860  Porphyrin metabolism
bel00920  Sulfur metabolism
KO pathway
ko00260   
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