KEGG   PATHWAY: bta04980
Entry
bta04980                    Pathway                                
Name
Cobalamin transport and metabolism - Bos taurus (cow)
Class
Organismal Systems; Digestive system
Pathway map
bta04980  Cobalamin transport and metabolism
bta04980

Organism
Bos taurus (cow) [GN:bta]
Gene
100300346  ZNF76; zinc finger protein 76 isoform X1 [KO:K20828]
112448521  [KO:K05678] [EC:7.6.2.8]
280869  MTR; methionine synthase [KO:K00548] [EC:2.1.1.13]
280871  MMUT; methylmalonyl-CoA mutase, mitochondrial precursor [KO:K01847] [EC:5.4.99.2]
281518  TCN2; transcobalamin-2 precursor [KO:K14619]
281997  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
505043  CD320; CD320 antigen precursor [KO:K06734]
507991  MTRR; methionine synthase reductase [KO:K00597] [EC:1.16.1.8]
510495  LMBRD1; lysosomal cobalamin transport escort protein LMBD1 [KO:K14617]
511673  MMAA; methylmalonic aciduria type A protein, mitochondrial [KO:K07588] [EC:3.6.5.-]
512908  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
513433  MMACHC; cyanocobalamin reductase / alkylcobalamin dealkylase [KO:K14618] [EC:1.16.1.6 2.5.1.151]
521533  MMADHC; cobalamin trafficking protein CblD [KO:K26006]
533243  ZNF143; zinc finger protein 143 [KO:K20828]
539845  THAP11; THAP domain-containing protein 11 [KO:K23211]
616239  TCN1; transcobalamin-1 precursor [KO:K25741]
616252  CBLIF; cobalamin binding intrinsic factor precursor [KO:K14615]
617636  MMAB; corrinoid adenosyltransferase MMAB precursor [KO:K00798] [EC:2.5.1.17]
Compound
C00073  L-Methionine
C00091  Succinyl-CoA
C00101  Tetrahydrofolate
C00155  L-Homocysteine
C00194  Cobamide coenzyme
C00440  5-Methyltetrahydrofolate
C00541  Cob(II)alamin
C01213  (R)-Methylmalonyl-CoA
C02823  Cyanocobalamin
C06409  [Methionine synthase]-cob(II)alamin
C06410  [Methionine synthase]-methylcob(III)alamin
C06453  Methylcobalamin
C08230  Hydroxocobalamin
C22880  [Methionine synthase]-cob(I)alamin
Reference
PMID:35337617
  Authors
Nijland M, Martinez Felices JM, Slotboom DJ, Thangaratnarajah C
  Title
Membrane transport of cobalamin.
  Journal
Vitam Horm 119:121-148 (2022)
DOI:10.1016/bs.vh.2022.01.008
Reference
PMID:35337623
  Authors
Hannibal L, Jacobsen DW
  Title
Intracellular processing of vitamin B(12) by MMACHC (CblC).
  Journal
Vitam Horm 119:275-298 (2022)
DOI:10.1016/bs.vh.2022.02.001
Reference
PMID:35337626
  Authors
Watkins D, Rosenblatt DS
  Title
Inherited defects of cobalamin metabolism.
  Journal
Vitam Horm 119:355-376 (2022)
DOI:10.1016/bs.vh.2022.01.010
Reference
PMID:36422244
  Authors
Kosa M, Galla Z, Lenart I, Barath A, Grecso N, Racz G, Bereczki C, Monostori P
  Title
Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency  Detected by Newborn Screening.
  Journal
Metabolites 12:metabo12111104 (2022)
DOI:10.3390/metabo12111104
Reference
PMID:20301503
  Authors
Sloan JL, Carrillo N, Adams D, Venditti CP
  Title
Disorders of Intracellular Cobalamin Metabolism.
  Journal
GeneReviews (1993)
Reference
PMID:23539619
  Authors
Gherasim C, Lofgren M, Banerjee R
  Title
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin.
  Journal
J Biol Chem 288:13186-93 (2013)
DOI:10.1074/jbc.R113.458810
Related
pathway
bta00270  Cysteine and methionine metabolism
bta00280  Valine, leucine and isoleucine degradation
bta00670  One carbon pool by folate
bta04144  Endocytosis
bta04977  Vitamin digestion and absorption
KO pathway
ko04980   

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