KEGG   PATHWAY: bum00290
Entry
bum00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Burkholderia sp. PAMC 26561
Class
Metabolism; Amino acid metabolism
Pathway map
bum00290  Valine, leucine and isoleucine biosynthesis
bum00290

Module
bum_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:bum00290]
bum_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:bum00290]
bum_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:bum00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Burkholderia sp. PAMC 26561 [GN:bum]
Gene
AXG89_07855  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AXG89_12700  pyridoxal-5'-phosphate-dependent protein subunit beta [KO:K01754] [EC:4.3.1.19]
AXG89_20025  isopropylmalate isomerase [KO:K01703] [EC:4.2.1.33 4.2.1.35]
AXG89_19235  isopropylmalate isomerase [KO:K01703] [EC:4.2.1.33 4.2.1.35]
AXG89_12930  3-isopropylmalate dehydratase [KO:K01703] [EC:4.2.1.33 4.2.1.35]
AXG89_12980  3-isopropylmalate dehydratase [KO:K01703] [EC:4.2.1.33 4.2.1.35]
AXG89_16325  3-isopropylmalate dehydratase [KO:K01703] [EC:4.2.1.33 4.2.1.35]
AXG89_34245  3-isopropylmalate dehydratase [KO:K01704] [EC:4.2.1.33 4.2.1.35]
AXG89_20035  3-isopropylmalate dehydratase [KO:K01704] [EC:4.2.1.33 4.2.1.35]
AXG89_19230  3-isopropylmalate dehydratase [KO:K01704] [EC:4.2.1.33 4.2.1.35]
AXG89_12935  3-isopropylmalate dehydratase [KO:K01704] [EC:4.2.1.33 4.2.1.35]
AXG89_12985  3-isopropylmalate dehydratase [KO:K01704] [EC:4.2.1.33 4.2.1.35]
AXG89_16320  3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
AXG89_20040  3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
AXG89_34240  3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
AXG89_31375  3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
AXG89_41270  acetolactate synthase [KO:K01652] [EC:2.2.1.6]
AXG89_00380  acetolactate synthase 3 catalytic subunit [KO:K01652] [EC:2.2.1.6]
AXG89_31235  hypothetical protein [KO:K01652] [EC:2.2.1.6]
AXG89_05485  thiamine pyrophosphate-binding protein [KO:K01652] [EC:2.2.1.6]
AXG89_00375  acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
AXG89_00370  ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
AXG89_40720  dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
AXG89_09625  dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
AXG89_08945  branched chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
AXG89_12640  aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
AXG89_00350  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
AXG89_07240  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
bum00260  Glycine, serine and threonine metabolism
bum00280  Valine, leucine and isoleucine degradation
bum00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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