KEGG   PATHWAY: bum00260
Entry
bum00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia sp. PAMC 26561
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bum00260  Glycine, serine and threonine metabolism
bum00260

Module
bum_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bum00260]
bum_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bum00260]
bum_M00555  Betaine biosynthesis, choline => betaine [PATH:bum00260]
bum_M00621  Glycine cleavage system [PATH:bum00260]
bum_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bum00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia sp. PAMC 26561 [GN:bum]
Gene
AXG89_11630  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AXG89_20045  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AXG89_12645  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AXG89_20280  homoserine kinase [KO:K02204] [EC:2.7.1.39]
AXG89_12650  threonine synthase [KO:K01733] [EC:4.2.3.1]
AXG89_00650  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AXG89_16890  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AXG89_34495  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AXG89_02995  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AXG89_19750  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AXG89_35975  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
AXG89_39510  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AXG89_17905  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AXG89_06560  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AXG89_01155  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AXG89_13870  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AXG89_12805  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AXG89_07075  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
AXG89_08075  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
AXG89_05995  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AXG89_01510  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
AXG89_14085  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AXG89_03000  NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AXG89_16695  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
AXG89_16700  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AXG89_05470  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
AXG89_37595  glycine dehydrogenase [KO:K00282] [EC:1.4.4.2]
AXG89_37590  glycine dehydrogenase [KO:K00283] [EC:1.4.4.2]
AXG89_05460  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
AXG89_17475  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AXG89_11310  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AXG89_14830  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AXG89_05465  glycine cleavage system protein H [KO:K02437]
AXG89_00360  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AXG89_19725  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
AXG89_19730  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AXG89_19785  (Fe-S)-binding protein [KO:K00479] [EC:1.14.13.251]
AXG89_37450  hypothetical protein [KO:K21832] [EC:1.14.13.251]
AXG89_19790  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
AXG89_19765  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
AXG89_19770  (Fe-S)-binding protein [KO:K21834]
AXG89_19775  electron transfer flavoprotein subunit alpha [KO:K25960]
AXG89_19780  drug:proton antiporter [KO:K25961]
AXG89_37025  methyltryptophan oxidase [KO:K00301] [EC:1.5.3.1]
AXG89_19660  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
AXG89_19650  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
AXG89_19665  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
AXG89_19655  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
AXG89_19645  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AXG89_05480  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AXG89_07855  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AXG89_12700  pyridoxal-5'-phosphate-dependent protein subunit beta [KO:K01754] [EC:4.3.1.19]
AXG89_07820  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
AXG89_20075  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AXG89_20065  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
AXG89_37585  hypothetical protein [KO:K15785] [EC:2.6.1.76]
AXG89_38510  hypothetical protein [KO:K15785] [EC:2.6.1.76]
AXG89_07535  hypothetical protein [KO:K15785] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bum00010  Glycolysis / Gluconeogenesis
bum00020  Citrate cycle (TCA cycle)
bum00230  Purine metabolism
bum00250  Alanine, aspartate and glutamate metabolism
bum00270  Cysteine and methionine metabolism
bum00290  Valine, leucine and isoleucine biosynthesis
bum00300  Lysine biosynthesis
bum00330  Arginine and proline metabolism
bum00460  Cyanoamino acid metabolism
bum00470  D-Amino acid metabolism
bum00564  Glycerophospholipid metabolism
bum00600  Sphingolipid metabolism
bum00620  Pyruvate metabolism
bum00630  Glyoxylate and dicarboxylate metabolism
bum00640  Propanoate metabolism
bum00680  Methane metabolism
bum00860  Porphyrin metabolism
bum00920  Sulfur metabolism
KO pathway
ko00260   
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