KEGG   PATHWAY: bvg04144
Entry
bvg04144                    Pathway                                
Name
Endocytosis - Beta vulgaris (sugar beet)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
bvg04144  Endocytosis
bvg04144

Other DBs
GO: 0006897
Organism
Beta vulgaris (sugar beet) [GN:bvg]
Gene
104908851  phosphatidylinositol 4-phosphate 5-kinase 9 [KO:K00889] [EC:2.7.1.68]
104891207  phosphatidylinositol 4-phosphate 5-kinase 1 [KO:K00889] [EC:2.7.1.68]
104890320  phosphatidylinositol 4-phosphate 5-kinase 10 [KO:K00889] [EC:2.7.1.68]
104887534  phosphatidylinositol 4-phosphate 5-kinase 6 [KO:K00889] [EC:2.7.1.68]
104886640  phosphatidylinositol 4-phosphate 5-kinase 1 [KO:K00889] [EC:2.7.1.68]
104889485  phosphatidylinositol 4-phosphate 5-kinase 4 [KO:K00889] [EC:2.7.1.68]
104896721  phosphatidylinositol 4-phosphate 5-kinase 8 [KO:K00889] [EC:2.7.1.68]
104905476  phospholipase D gamma 1 [KO:K01115] [EC:3.1.4.4]
104906514  phospholipase D zeta 1 [KO:K01115] [EC:3.1.4.4]
104902031  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
104904566  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
104908837  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
104892362  phospholipase D beta 1 [KO:K01115] [EC:3.1.4.4]
104890344  phospholipase D zeta 1 [KO:K01115] [EC:3.1.4.4]
104883871  phospholipase D delta [KO:K01115] [EC:3.1.4.4]
104897785  phospholipase D delta [KO:K01115] [EC:3.1.4.4]
104894174  phospholipase D gamma 1 [KO:K01115] [EC:3.1.4.4]
104900365  phospholipase D alpha 4 [KO:K01115] [EC:3.1.4.4]
104897029  dynamin-2B [KO:K01528] [EC:3.6.5.5]
104899929  clathrin heavy chain 1 [KO:K04646]
104903190  clathrin heavy chain 1 [KO:K04646]
104903612  AP-2 complex subunit alpha-1-like [KO:K11824]
104892929  AP-2 complex subunit mu [KO:K11826]
104895200  AP-2 complex subunit sigma [KO:K11827]
104886330  clathrin interactor EPSIN 1 [KO:K12471]
104893823  clathrin interactor EPSIN 2 [KO:K12471]
104900120  epsin-3 [KO:K12471]
104901112  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
104904066  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
104895177  hypothetical protein [KO:K19366]
104903935  hypothetical protein [KO:K19366]
104895232  actin-related protein 2 [KO:K17260]
104897225  actin-related protein 3 [KO:K18584]
104903586  actin-related protein 2/3 complex subunit 1B [KO:K05757]
104887884  actin-related protein 2/3 complex subunit 2B [KO:K05758]
104897253  actin-related protein 2/3 complex subunit 2A [KO:K05758]
104901912  actin-related protein 2/3 complex subunit 3 [KO:K05756]
104901920  actin-related protein 2/3 complex subunit 3 [KO:K05756]
104888447  actin-related protein 2/3 complex subunit 4 [KO:K05755]
104905289  actin-related protein 2/3 complex subunit 5A [KO:K05754]
104896692  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
104894215  heat shock cognate 70 kDa protein-like [KO:K03283]
104894252  heat shock 70 kDa protein 18-like [KO:K03283]
104894264  heat shock 70 kDa protein 18-like [KO:K03283]
104894288  heat shock cognate 70 kDa protein 2-like [KO:K03283]
104893153  heat shock cognate 70 kDa protein-like [KO:K03283]
104892997  heat shock cognate 70 kDa protein-like [KO:K03283]
104893031  heat shock 70 kDa protein 18-like [KO:K03283]
104893107  heat shock cognate 70 kDa protein-like [KO:K03283]
104893116  heat shock cognate 70 kDa protein-like [KO:K03283]
104893125  heat shock 70 kDa protein 18-like [KO:K03283]
104893144  heat shock cognate 70 kDa protein-like [KO:K03283]
104893923  heat shock 70 kDa protein-like [KO:K03283]
104900138  heat shock cognate 70 kDa protein 2 [KO:K03283]
104885114  heat shock cognate 70 kDa protein-like [KO:K03283]
104901718  heat shock 70 kDa protein-like [KO:K03283]
104890314  F-actin-capping protein subunit alpha [KO:K10364]
104884806  probable F-actin-capping protein subunit beta [KO:K10365]
104883942  vacuolar protein sorting-associated protein 29 [KO:K18467]
104895365  vacuolar protein sorting-associated protein 26A [KO:K18466]
104905610  vacuolar protein sorting-associated protein 35B [KO:K18468]
104895155  vacuolar protein sorting-associated protein 35A [KO:K18468]
104887847  AMSH-like ubiquitin thioesterase 3 [KO:K11866] [EC:3.4.19.12]
104897386  AMSH-like ubiquitin thioesterase 2 [KO:K11866] [EC:3.4.19.12]
104893579  AMSH-like ubiquitin thioesterase 1 [KO:K11866] [EC:3.4.19.12]
104902211  ras-related protein Rab7A [KO:K07897]
104904370  ras-related protein Rab7 [KO:K07897]
104896408  ras-related protein Rab7 [KO:K07897]
104884852  ras-related protein RABG3c [KO:K07897]
104896072  ras-related protein Rab7 [KO:K07897]
104894693  protein ELC-like [KO:K12183]
104887212  protein ELC-like [KO:K12183]
104902613  vacuolar protein sorting-associated protein 28 homolog 1 [KO:K12184]
104909113  vacuolar protein sorting-associated protein 28 homolog 2 [KO:K12184]
104883741  vacuolar protein-sorting-associated protein 37 homolog 1 [KO:K12185]
104898592  vacuolar protein-sorting-associated protein 37 homolog 1 [KO:K12185]
104891647  vacuolar protein sorting-associated protein 22 homolog 1 [KO:K12188]
104883788  vacuolar protein sorting-associated protein 36 [KO:K12190]
104882853  vacuolar protein sorting-associated protein 20 homolog 2 [KO:K12195]
104907797  vacuolar protein sorting-associated protein 32 homolog 2 [KO:K12194]
104903716  vacuolar protein sorting-associated protein 32 homolog 1 [KO:K12194]
104899818  vacuolar protein sorting-associated protein 24 homolog 1 [KO:K12193]
104887611  vacuolar protein sorting-associated protein 2 homolog 1 [KO:K12191]
104883612  vacuolar protein sorting-associated protein 2 homolog 1 [KO:K12191]
104899194  vacuolar protein sorting-associated protein 2 homolog 3 [KO:K12192]
104903116  charged multivesicular body protein 7 [KO:K15053]
104900334  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 [KO:K12196]
104891751  protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5 [KO:K12199]
104903691  ESCRT-related protein CHMP1B [KO:K12197]
104905598  ESCRT-related protein CHMP1B [KO:K12197]
104907805  charged multivesicular body protein 5 [KO:K12198]
104896626  ALG-2 interacting protein X [KO:K12200]
104892438  maspardin [KO:K19367]
104898321  sorting nexin 1 [KO:K17917]
104884720  ras-related protein RABF1 [KO:K07888]
109134436  ras-related protein RHN1-like [KO:K07888]
104893838  ras-related protein RABF2a-like [KO:K07888]
104902185  ras-related protein RHN1 [KO:K07889]
104887428  ras-related protein RABF1 [KO:K07889]
104904664  ras-related protein RHN1-like [KO:K07889]
104891258  ras-related protein RHN1 [KO:K07889]
104891736  EH domain-containing protein 1 [KO:K12483]
104891744  EH domain-containing protein 1 [KO:K12483]
104883013  EH domain-containing protein 1-like [KO:K12483]
104884005  vacuolar protein sorting-associated protein 45 homolog [KO:K12479]
104900163  ras-related protein RAB1BV [KO:K07901]
104898778  ras-related protein RABE1c [KO:K07901]
104895151  ras-related protein RAB1BV-like [KO:K07901]
104903396  ras-related protein YPT3 [KO:K07904]
104900042  ras-related protein Rab2BV [KO:K07904]
104902505  ras-related protein RABA5a [KO:K07904]
104904921  ras-related protein Rab2BV [KO:K07904]
104906515  ras-related protein RABA3 [KO:K07904]
104889717  ras-related protein RABA5d [KO:K07904]
104889246  ras-related protein RABA4d [KO:K07904]
104908049  ras-related protein RABA4d [KO:K07904]
104896691  ras-related protein RABA2a [KO:K07904]
104896017  ras-related protein Rab11D [KO:K07904]
104900516  ras-related protein RIC2 [KO:K07904]
104891443  ras-related protein RABA1f [KO:K07904]
104900603  ras-related protein RABA1f [KO:K07904]
104907225  probable ADP-ribosylation factor GTPase-activating protein AGD5 [KO:K12486]
104887511  probable ADP-ribosylation factor GTPase-activating protein AGD11 [KO:K12486]
104909110  probable ADP-ribosylation factor GTPase-activating protein AGD5 [KO:K12486]
104901418  probable ADP-ribosylation factor GTPase-activating protein AGD15 [KO:K12486]
104901231  ADP-ribosylation factor GTPase-activating protein AGD12 [KO:K12486]
104897460  ADP-ribosylation factor GTPase-activating protein AGD3 [KO:K12489]
104893913  ADP-ribosylation factor GTPase-activating protein AGD3-like [KO:K12489]
104899576  ADP-ribosylation factor GTPase-activating protein AGD3 [KO:K12489]
104902633  ADP-ribosylation factor GTPase-activating protein AGD4 [KO:K12489]
104893621  probable ADP-ribosylation factor GTPase-activating protein AGD6 [KO:K12492]
104892908  probable ADP-ribosylation factor GTPase-activating protein AGD9 [KO:K12493]
104905422  brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
104904095  brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
104906035  ARF guanine-nucleotide exchange factor GNOM [KO:K18443]
104897851  ARF guanine-nucleotide exchange factor GNOM [KO:K18443]
104902176  ARF guanine-nucleotide exchange factor GNL2 [KO:K18443]
104904964  ADP-ribosylation factor 1-like [KO:K07937]
104890669  ADP-ribosylation factor [KO:K07937]
104907585  ADP-ribosylation factor 1 [KO:K07937]
104897375  ADP-ribosylation factor 2 [KO:K07937]
104889133  ADP-ribosylation factor [KO:K07937]
104894820  ADP-ribosylation factor 2-B [KO:K07937]
104894998  ADP-ribosylation factor 1-like [KO:K07937]
109135299  ADP-ribosylation factor 1-like [KO:K07937]
104894997  ADP-ribosylation factor-like [KO:K07937]
104888026  ADP-ribosylation factor [KO:K07937]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
bvg04070  Phosphatidylinositol signaling system
bvg04130  SNARE interactions in vesicular transport
KO pathway
ko04144   
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