KEGG   PATHWAY: cfb00520
Entry
cfb00520                    Pathway                                
Name
Amino sugar and nucleotide sugar metabolism - Clostridium felsineum DSM 794
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
cfb00520  Amino sugar and nucleotide sugar metabolism
cfb00520

Module
cfb_M00549  UDP-Glc biosynthesis, Glc => UDP-Glc [PATH:cfb00520]
cfb_M00554  UDP-Gal biosynthesis, Gal => UDP-Gal [PATH:cfb00520]
cfb_M00909  UDP-GlcNAc biosynthesis, prokaryotes, Fru-6P => UDP-GlcNAc [PATH:cfb00520]
cfb_M00995  UDP-MurNAc biosynthesis, Fru-6P => UDP-MurNAc [PATH:cfb00520]
cfb_M01000  GDP-Man biosynthesis, Fru-6P => GDP-Man [PATH:cfb00520]
cfb_M01004  UDP-Galf biosynthesis, UDP-Glc => UDP-Galf [PATH:cfb00520]
Other DBs
GO: 0006040 0009225
Organism
Clostridium felsineum DSM 794 [GN:cfb]
Gene
CLFE_001670  gamA; putative glucosamine-6-phosphate deaminase 2 [KO:K02564] [EC:3.5.99.6]
CLFE_001680  nagA; N-acetylglucosamine-6-phosphate deacetylase [KO:K01443] [EC:3.5.1.25]
CLFE_001690  murQ_1; N-acetylmuramic acid 6-phosphate etherase [KO:K07106] [EC:4.2.1.126]
CLFE_001710  manX_1; PTS system mannose-specific EIIAB component [KO:K02794] [EC:2.7.1.191]
CLFE_001720  sorA_1; PTS system sorbose-specific EIIC component [KO:K02795]
CLFE_001730  manZ_1; PTS system mannose-specific EIID component [KO:K02796]
CLFE_003680  murAB; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 [KO:K00790] [EC:2.5.1.7]
CLFE_004320  xynB_1; Beta-xylosidase [KO:K01198] [EC:3.2.1.37]
CLFE_006750  glmU; Bifunctional protein GlmU [KO:K04042] [EC:2.7.7.23 2.3.1.157]
CLFE_008520  rfbM; Mannose-1-phosphate guanylyltransferase RfbM [KO:K00971] [EC:2.7.7.13]
CLFE_008760  algA_1; Alginate biosynthesis protein AlgA [KO:K00971] [EC:2.7.7.13]
CLFE_009510  galT_1; Galactose-1-phosphate uridylyltransferase [KO:K00965] [EC:2.7.7.12]
CLFE_009520  galE_1; UDP-glucose 4-epimerase [KO:K01784] [EC:5.1.3.2]
CLFE_009530  galK_1; Galactokinase [KO:K00849] [EC:2.7.1.6]
CLFE_009950  manA_1; Mannose-6-phosphate isomerase ManA [KO:K01809] [EC:5.3.1.8]
CLFE_010370  mnaA; UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
CLFE_010490  murAA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 [KO:K00790] [EC:2.5.1.7]
CLFE_010710  galT_2; Galactose-1-phosphate uridylyltransferase [KO:K00965] [EC:2.7.7.12]
CLFE_013990  pgi; Glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
CLFE_016770  galK_2; Galactokinase [KO:K00849] [EC:2.7.1.6]
CLFE_019220  nagP; PTS system N-acetylglucosamine-specific EIICB component [KO:K02804] [EC:2.7.1.193]
CLFE_019750  gtaB_1; UTP--glucose-1-phosphate uridylyltransferase [KO:K00963] [EC:2.7.7.9]
CLFE_019870  glgD; Glycogen biosynthesis protein GlgD [KO:K00975] [EC:2.7.7.27]
CLFE_019880  glgC; Glucose-1-phosphate adenylyltransferase [KO:K00975] [EC:2.7.7.27]
CLFE_020410  rfbF; Glucose-1-phosphate cytidylyltransferase [KO:K00978] [EC:2.7.7.33]
CLFE_020670  rfbD; UDP-galactopyranose mutase [KO:K01854] [EC:5.4.99.9]
CLFE_025860  gmuE; Putative fructokinase [KO:K00847] [EC:2.7.1.4]
CLFE_027640  galE_2; UDP-glucose 4-epimerase [KO:K01784] [EC:5.1.3.2]
CLFE_028840  rmlA; Glucose-1-phosphate thymidylyltransferase [KO:K00973] [EC:2.7.7.24]
CLFE_028850  [KO:K01784] [EC:5.1.3.2]
CLFE_028860  gtaB_2; UTP--glucose-1-phosphate uridylyltransferase [KO:K00963] [EC:2.7.7.9]
CLFE_028880  pgcA; Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
CLFE_033200  glcK; Glucokinase [KO:K25026]
CLFE_033340  [KO:K01198] [EC:3.2.1.37]
CLFE_033400  nag3; Beta-N-acetylglucosaminidase/beta-glucosidase [KO:K01207] [EC:3.2.1.52]
CLFE_037900  crr; PTS system glucose-specific EIIA component [KO:K02777] [EC:2.7.1.-]
CLFE_038130  gamP; Putative PTS system glucosamine-specific EIICBA component [KO:K20118] [EC:2.7.1.199]
CLFE_039040  algA_2; Alginate biosynthesis protein AlgA [KO:K00971] [EC:2.7.7.13]
CLFE_039180  cugP; UTP--glucose-1-phosphate uridylyltransferase [KO:K16881] [EC:2.7.7.13 5.4.2.8]
CLFE_039320  glcB; PTS system glucoside-specific EIICBA component [KO:K02777] [EC:2.7.1.-]
CLFE_039920  murB; UDP-N-acetylenolpyruvoylglucosamine reductase [KO:K00075] [EC:1.3.1.98]
CLFE_040200  glmM; Phosphoglucosamine mutase [KO:K03431] [EC:5.4.2.10]
CLFE_040600  xynB_2; Beta-xylosidase [KO:K01198] [EC:3.2.1.37]
CLFE_041040  scrK; Fructokinase [KO:K00847] [EC:2.7.1.4]
CLFE_041350  manZ_2; PTS system mannose-specific EIID component [KO:K02796]
CLFE_041360  sorA_2; PTS system sorbose-specific EIIC component [KO:K02795]
CLFE_041370  manX_2; PTS system mannose-specific EIIAB component [KO:K02794] [EC:2.7.1.191]
CLFE_041380  manX_3; PTS system mannose-specific EIIAB component [KO:K02793] [EC:2.7.1.191]
CLFE_044210  nagB; Glucosamine-6-phosphate deaminase 1 [KO:K02564] [EC:3.5.99.6]
CLFE_044300  murK; N-acetylmuramic acid/N-acetylglucosamine kinase [KO:K28208]
CLFE_044310  nagZ; Beta-hexosaminidase [KO:K01207] [EC:3.2.1.52]
CLFE_044390  murQ_2; N-acetylmuramic acid 6-phosphate etherase [KO:K07106] [EC:4.2.1.126]
CLFE_044890  glmS; Glutamine--fructose-6-phosphate aminotransferase [isomerizing] [KO:K00820] [EC:2.6.1.16]
CLFE_045420  [KO:K15921] [EC:3.2.1.55]
Compound
C00029  UDP-glucose
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00052  UDP-alpha-D-galactose
C00085  D-Fructose 6-phosphate
C00095  D-Fructose
C00096  GDP-mannose
C00103  D-Glucose 1-phosphate
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00167  UDP-glucuronate
C00181  D-Xylose
C00190  UDP-D-xylose
C00191  D-Glucuronate
C00203  UDP-N-acetyl-D-galactosamine
C00216  D-Arabinose
C00259  L-Arabinose
C00267  alpha-D-Glucose
C00275  D-Mannose 6-phosphate
C00325  GDP-L-fucose
C00329  D-Glucosamine
C00333  D-Galacturonate
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00394  GDP-glucose
C00446  alpha-D-Galactose 1-phosphate
C00461  Chitin
C00498  ADP-glucose
C00501  CDP-glucose
C00617  UDP-D-galacturonate
C00636  D-Mannose 1-phosphate
C00645  N-Acetyl-D-mannosamine
C00668  alpha-D-Glucose 6-phosphate
C00714  Pectin
C00734  Chitosan
C00842  dTDP-glucose
C00935  UDP-L-arabinose
C00976  GDP-D-mannuronate
C00984  alpha-D-Galactose
C01019  L-Fucose
C01050  UDP-N-acetylmuramate
C01132  N-Acetyl-D-galactosamine
C01170  UDP-N-acetyl-D-mannosamine
C01623  UDP-apiose
C01674  Chitobiose
C02262  D-Galactosamine
C02280  GDP-L-galactose
C02352  1,4-beta-D-Xylan
C02474  Arabinan
C02713  N-Acetylmuramate
C02985  L-Fucose 1-phosphate
C03733  UDP-alpha-D-galactofuranose
C03737  alpha-D-Xylose 1-phosphate
C03906  beta-L-Arabinose 1-phosphate
C04037  1-Phospho-alpha-D-galacturonate
C04257  N-Acetyl-D-mannosamine 6-phosphate
C04501  N-Acetyl-alpha-D-glucosamine 1-phosphate
C04631  UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C05385  D-Glucuronate 1-phosphate
C06023  D-Glucosaminide
C06156  alpha-D-Glucosamine 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11521  UDP-6-sulfoquinovose
C15925  GDP-L-gulose
C16183  alpha-D-Arabinopyranose 1-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C17269  GDP-D-arabinopyranose
C18060  N-Acetyl-alpha-D-galactosamine 1-phosphate
C18094  UDP-L-arabinofuranose
C19769  1,6-Anhydro-N-acetyl-beta-muramate
C21027  N-Acetylmuramic acid alpha-1-phosphate
C22029  alpha-D-Galactosamine 1-phosphate
Reference
PMID:2793832
  Authors
Wyk P, Reeves P
  Title
Identification and sequence of the gene for abequose synthase, which confers antigenic specificity on group B salmonellae: homology with galactose epimerase.
  Journal
J Bacteriol 171:5687-93 (1989)
DOI:10.1128/JB.171.10.5687-5693.1989
Reference
PMID:8071227
  Authors
Thorson JS, Lo SF, Ploux O, He X, Liu HW
  Title
Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA.
  Journal
J Bacteriol 176:5483-93 (1994)
DOI:10.1128/JB.176.17.5483-5493.1994
Reference
PMID:8444803
  Authors
Kessler AC, Haase A, Reeves PR
  Title
Molecular analysis of the 3,6-dideoxyhexose pathway genes of Yersinia pseudotuberculosis serogroup IIA.
  Journal
J Bacteriol 175:1412-22 (1993)
DOI:10.1128/JB.175.5.1412-1422.1993
Reference
PMID:9811644
  Authors
Danese PN, Oliver GR, Barr K, Bowman GD, Rick PD, Silhavy TJ
  Title
Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.
  Journal
J Bacteriol 180:5875-84 (1998)
DOI:10.1128/JB.180.22.5875-5884.1998
Reference
  Authors
Skurnik M, Peippo A, Ervela E
  Title
Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b.
  Journal
Mol Microbiol 37:316-30 (2000)
DOI:10.1046/j.1365-2958.2000.01993.x
Reference
  Authors
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV
  Title
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
  Journal
Nature 406:959-64 (2000)
DOI:10.1038/35023079
Reference
  Authors
Ringenberg M, Lichtensteiger C, Vimr E
  Title
Redirection of sialic acid metabolism in genetically engineered Escherichia coli.
  Journal
Glycobiology 11:533-9 (2001)
DOI:10.1093/glycob/11.7.533
Reference
  Authors
McCoy AJ, Sandlin RC, Maurelli AT
  Title
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance.
  Journal
J Bacteriol 185:1218-28 (2003)
DOI:10.1128/JB.185.4.1218-1228.2003
Reference
  Authors
JACOBSON B, DAVIDSON EA
  Title
Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase.
  Journal
J Biol Chem 237:638-42 (1962)
Reference
  Authors
Seifert GJ
  Title
Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside.
  Journal
Curr Opin Plant Biol 7:277-84 (2004)
DOI:10.1016/j.pbi.2004.03.004
Reference
  Authors
Uehara T, Park JT
  Title
The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling.
  Journal
J Bacteriol 186:7273-9 (2004)
DOI:10.1128/JB.186.21.7273-7279.2004
Reference
  Authors
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR.
  Title
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
  Journal
J Biol Chem 280:14154-67 (2005)
DOI:10.1074/jbc.M414265200
Reference
  Authors
Williams GJ, Breazeale SD, Raetz CR, Naismith JH.
  Title
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
  Journal
J Biol Chem 280:23000-8 (2005)
DOI:10.1074/jbc.M501534200
Reference
  Authors
Maliekal P, Vertommen D, Delpierre G, Van Schaftingen E
  Title
Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase.
  Journal
Glycobiology 16:165-72 (2006)
DOI:10.1093/glycob/cwj050
Reference
  Authors
Campbell CT, Yarema KJ
  Title
Large-scale approaches for glycobiology.
  Journal
Genome Biol 6:236 (2005)
DOI:10.1186/gb-2005-6-11-236
Reference
  Authors
Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT
  Title
MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.
  Journal
J Bacteriol 188:1660-2 (2006)
DOI:10.1128/JB.188.4.1660-1662.2006
Reference
  Authors
Lanot A, Hodge D, Jackson RG, George GL, Elias L, Lim EK, Vaistij FE, Bowles DJ
  Title
The glucosyltransferase UGT72E2 is responsible for monolignol 4-O-glucoside production in Arabidopsis thaliana.
  Journal
Plant J 48:286-95 (2006)
DOI:10.1111/j.1365-313X.2006.02872.x
Reference
  Authors
Muller R, Morant M, Jarmer H, Nilsson L, Nielsen TH
  Title
Genome-wide analysis of the Arabidopsis leaf transcriptome reveals interaction of phosphate and sugar metabolism.
  Journal
Plant Physiol 143:156-71 (2007)
DOI:10.1104/pp.106.090167
Reference
  Authors
Oka T, Nemoto T, Jigami Y
  Title
Functional analysis of Arabidopsis thaliana RHM2/MUM4, a multidomain protein involved in UDP-D-glucose to UDP-L-rhamnose conversion.
  Journal
J Biol Chem 282:5389-403 (2007)
DOI:10.1074/jbc.M610196200
Reference
  Authors
Greenberg DE, Porcella SF, Zelazny AM, Virtaneva K, Sturdevant DE, Kupko JJ 3rd, Barbian KD, Babar A, Dorward DW, Holland SM.
  Title
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.
  Journal
J Bacteriol 189:8727-36 (2007)
DOI:10.1128/JB.00793-07
Reference
  Authors
Kotake T, Hojo S, Tajima N, Matsuoka K, Koyama T, Tsumuraya Y
  Title
A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.
  Journal
J Biol Chem 283:8125-35 (2008)
DOI:10.1074/jbc.M710078200
Reference
  Authors
Vorholter FJ, Schneiker S, Goesmann A, Krause L, Bekel T, Kaiser O, Linke B, Patschkowski T, Ruckert C, Schmid J, Sidhu VK, Sieber V, Tauch A, Watt SA, Weisshaar B, Becker A, Niehaus K, Puhler A.
  Title
The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis.
  Journal
J Biotechnol 134:33-45 (2008)
DOI:10.1016/j.jbiotec.2007.12.013
Reference
  Authors
Albermann C, Piepersberg W
  Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
  Journal
Glycobiology 11:655-61 (2001)
DOI:10.1093/glycob/11.8.655
Related
pathway
cfb00010  Glycolysis / Gluconeogenesis
cfb00040  Pentose and glucuronate interconversions
cfb00051  Fructose and mannose metabolism
cfb00052  Galactose metabolism
cfb00053  Ascorbate and aldarate metabolism
cfb00500  Starch and sucrose metabolism
cfb00521  Streptomycin biosynthesis
cfb00523  Polyketide sugar unit biosynthesis
cfb00525  Acarbose and validamycin biosynthesis
cfb00541  Biosynthesis of various nucleotide sugars
cfb00550  Peptidoglycan biosynthesis
KO pathway
ko00520   

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