KEGG   PATHWAY: cfr04721
Entry
cfr04721                    Pathway                                
Name
Synaptic vesicle cycle - Camelus ferus (Wild Bactrian camel)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
Pathway map
cfr04721  Synaptic vesicle cycle
cfr04721

Other DBs
GO: 0016079 0048488
Organism
Camelus ferus (Wild Bactrian camel) [GN:cfr]
Gene
102523431  SLC32A1; LOW QUALITY PROTEIN: vesicular inhibitory amino acid transporter [KO:K15015]
102523059  SLC18A1; chromaffin granule amine transporter [KO:K08155]
102523925  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
102516553  SLC18A3; vesicular acetylcholine transporter [KO:K14636]
102518698  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
102508498  SLC17A8; vesicular glutamate transporter 3 isoform X1 [KO:K12302]
102514706  SLC17A6; vesicular glutamate transporter 2 isoform X1 [KO:K12302]
102511939  SYT1; synaptotagmin-1 [KO:K15290]
102504458  VAMP2; vesicle-associated membrane protein 2 isoform X1 [KO:K13504]
102505569  RAB3A; ras-related protein Rab-3A [KO:K07882]
102511264  RIMS1; LOW QUALITY PROTEIN: regulating synaptic membrane exocytosis protein 1 [KO:K15291]
102513495  STX1A; syntaxin-1A isoform X1 [KO:K04560]
102522794  STX2; syntaxin-2 isoform X1 [KO:K08486]
102516529  STX1B; syntaxin-1B isoform X1 [KO:K08486]
102514285  STX3; syntaxin-3 isoform X1 [KO:K08486]
102504162  STXBP1; syntaxin-binding protein 1 isoform X1 [KO:K15292]
102511994  UNC13A; protein unc-13 homolog A isoform X1 [KO:K15293]
102515705  UNC13C; protein unc-13 homolog C [KO:K15293]
102504108  protein unc-13 homolog B isoform X11 [KO:K15293]
102512296  SNAP25; synaptosomal-associated protein 25 isoform X1 [KO:K18211]
102506875  CPLX1; complexin-1 [KO:K15294]
102508691  CPLX2; complexin-2 [KO:K15294]
102518601  CPLX3; complexin-3 [KO:K15295]
102515078  CPLX4; complexin-4 [KO:K15295]
102516820  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102521766  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
102514292  NSF; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
102503646  NAPA; alpha-soluble NSF attachment protein isoform X1 [KO:K15296]
102504580  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
102522953  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
102505802  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
102520377  CLTA; clathrin light chain A isoform X5 [KO:K04644]
102517125  CLTB; clathrin light chain B isoform X1 [KO:K04645]
102514980  CLTC; clathrin heavy chain 1 isoform X2 [KO:K04646]
102504530  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
102508783  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
102521438  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
102505021  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
102514025  AP2S1; AP-2 complex subunit sigma [KO:K11827]
102523779  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
102519938  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
102508007  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
102511673  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
102518889  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
102518855  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
102510520  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
106729767  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
102522053  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
102509813  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
102524190  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
102506842  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
102520543  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
102519197  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
102523048  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
102520369  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
102505274  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
102509234  ATP6V0D2; LOW QUALITY PROTEIN: V-type proton ATPase subunit d 2 [KO:K02146]
102514182  ATP6V1H; LOW QUALITY PROTEIN: V-type proton ATPase subunit H [KO:K02144]
102512552  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit isoform X1 [KO:K02155]
102516340  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
102511412  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
102509520  SLC6A2; sodium-dependent noradrenaline transporter [KO:K05035]
102510470  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
102508774  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
102515145  SLC6A9; sodium- and chloride-dependent glycine transporter 1 isoform X4 [KO:K05038]
102515507  SLC6A5; sodium- and chloride-dependent glycine transporter 2 [KO:K05038]
102515201  SLC6A7; sodium-dependent proline transporter [KO:K05040]
102511655  SLC6A11; sodium- and chloride-dependent GABA transporter 3 isoform X1 [KO:K05044]
102520338  SLC6A12; sodium- and chloride-dependent betaine transporter isoform X3 [KO:K05045]
102523380  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
102521832  SLC1A1; excitatory amino acid transporter 3 isoform X2 [KO:K05612]
102522035  SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
102503505  SLC1A3; excitatory amino acid transporter 1 isoform X1 [KO:K05614]
102522503  SLC1A6; excitatory amino acid transporter 4 [KO:K05617]
102520178  SLC1A7; excitatory amino acid transporter 5 isoform X1 [KO:K05618]
Compound
C00002  ATP
C00025  L-Glutamate
C00037  Glycine
C00076  Calcium cation
C00080  H+
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00780  Serotonin
C01996  Acetylcholine
C03758  Dopamine
C16041  Leu-enkephalin
Reference
PMID:12827282
  Authors
Li L, Chin LS
  Title
The molecular machinery of synaptic vesicle exocytosis.
  Journal
Cell Mol Life Sci 60:942-60 (2003)
DOI:10.1007/s00018-003-2240-7
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
PMID:18275379
  Authors
Chapman ER
  Title
How does synaptotagmin trigger neurotransmitter release?
  Journal
Annu Rev Biochem 77:615-41 (2008)
DOI:10.1146/annurev.biochem.77.062005.101135
Reference
PMID:10212473
  Authors
Benfenati F, Onofri F, Giovedi S
  Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
  Journal
Philos Trans R Soc Lond B Biol Sci 354:243-57 (1999)
DOI:10.1098/rstb.1999.0376
Reference
PMID:20634814
  Authors
de Saint Basile G, Menasche G, Fischer A
  Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
  Journal
Nat Rev Immunol 10:568-79 (2010)
DOI:10.1038/nri2803
Reference
PMID:17767192
  Authors
Carr CM, Munson M
  Title
Tag team action at the synapse.
  Journal
EMBO Rep 8:834-8 (2007)
DOI:10.1038/sj.embor.7401051
Reference
PMID:15217342
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle.
  Journal
Annu Rev Neurosci 27:509-47 (2004)
DOI:10.1146/annurev.neuro.26.041002.131412
Reference
PMID:12563290
  Authors
Gundelfinger ED, Kessels MM, Qualmann B
  Title
Temporal and spatial coordination of exocytosis and endocytosis.
  Journal
Nat Rev Mol Cell Biol 4:127-39 (2003)
DOI:10.1038/nrm1016
Reference
PMID:16990140
  Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
  Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
  Journal
Cell 126:1175-87 (2006)
DOI:10.1016/j.cell.2006.08.030
Reference
PMID:12094216
  Authors
Chapman ER
  Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
  Journal
Nat Rev Mol Cell Biol 3:498-508 (2002)
DOI:10.1038/nrm855
Reference
PMID:7791897
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
  Journal
Nature 375:645-53 (1995)
DOI:10.1038/375645a0
Reference
PMID:12154365
  Authors
Rizo J, Sudhof TC
  Title
Snares and Munc18 in synaptic vesicle fusion.
  Journal
Nat Rev Neurosci 3:641-53 (2002)
DOI:10.1038/nrn898
Reference
PMID:18726177
  Authors
Malsam J, Kreye S, Sollner TH
  Title
Membrane fusion: SNAREs and regulation.
  Journal
Cell Mol Life Sci 65:2814-32 (2008)
DOI:10.1007/s00018-008-8352-3
Related
pathway
cfr04144  Endocytosis
cfr04724  Glutamatergic synapse
cfr04725  Cholinergic synapse
cfr04726  Serotonergic synapse
cfr04727  GABAergic synapse
cfr04728  Dopaminergic synapse
KO pathway
ko04721   
LinkDB

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