KEGG   PATHWAY: cfr04144
Entry
cfr04144                    Pathway                                
Name
Endocytosis - Camelus ferus (Wild Bactrian camel)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
cfr04144  Endocytosis
cfr04144

Other DBs
GO: 0006897
Organism
Camelus ferus (Wild Bactrian camel) [GN:cfr]
Gene
102517843  ARF6; ADP-ribosylation factor 6 [KO:K07941]
102517441  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
102505269  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
102516377  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X6 [KO:K00889] [EC:2.7.1.68]
102507163  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
102520901  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
102505040  PLD1; phospholipase D1 isoform X3 [KO:K01115] [EC:3.1.4.4]
102504580  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
102522953  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
102505802  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
102520377  CLTA; clathrin light chain A isoform X5 [KO:K04644]
102517125  CLTB; clathrin light chain B isoform X1 [KO:K04645]
102514980  CLTC; clathrin heavy chain 1 isoform X2 [KO:K04646]
102504530  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
102508783  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
102521438  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
102505021  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
102514025  AP2S1; AP-2 complex subunit sigma [KO:K11827]
102524321  EHD2; EH domain-containing protein 2 [KO:K12469]
102522485  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102509744  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102511870  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
102503924  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
102504760  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
102508588  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
102523073  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
102506651  TFRC; transferrin receptor protein 1 [KO:K06503]
102504272  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102512589  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102516073  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
102512878  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102510147  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102524338  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102504124  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
102515465  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
102508318  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
102523996  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
102512670  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
102516855  SH3GL2; endophilin-A1 isoform X1 [KO:K11247]
102519449  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
102511650  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
102506637  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
102511848  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
102519243  AMPH; amphiphysin isoform X1 [KO:K12562]
102508326  EPN3; epsin-3 isoform X1 [KO:K12471]
102508163  LOW QUALITY PROTEIN: epsin-2 [KO:K12471]
102522869  EPN1; epsin-1 isoform X1 [KO:K12471]
116663847  LOW QUALITY PROTEIN: epsin-1-like [KO:K12471]
102508609  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
102519345  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
102517374  SPART; LOW QUALITY PROTEIN: spartin [KO:K19366]
102505098  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
102513659  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X11 [KO:K13305] [EC:2.3.2.26]
102522420  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102520181  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102508757  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
102524299  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
102514579  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
102507049  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
102509478  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
102506814  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
102523694  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
102507450  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
102511990  CCR5; C-C chemokine receptor type 5 [KO:K04180]
102512865  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
106729878  CXCR2; C-X-C chemokine receptor type 2 isoform X2 [KO:K05050]
102513077  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102520487  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
102513037  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
102523137  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
102505202  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
102524130  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
102522133  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
102518408  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
102507805  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
102523739  ARRB2; beta-arrestin-2 [KO:K04439]
102504610  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
102507886  ACTR2; actin-related protein 2 [KO:K17260]
102517791  ACTR3; actin-related protein 3 [KO:K18584]
102506683  ACTR3B; LOW QUALITY PROTEIN: actin-related protein 3B [KO:K18584]
102516801  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
102514488  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
102513102  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
102506971  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
102515804  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
102517144  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
102509395  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 5 [KO:K05754]
102511602  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
102514022  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
102524367  WIPF2; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475]
102515435  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
102516558  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
102517440  HSPA1L; heat shock 70 kDa protein 1-like isoform X2 [KO:K03283]
102517682  heat shock 70 kDa protein 1B [KO:K03283]
102521559  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
116658237  heat shock 70 kDa protein 1B [KO:K03283]
102519473  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X4 [KO:K09526]
102521873  WASHC4; LOW QUALITY PROTEIN: WASH complex subunit 4 [KO:K18465]
102517689  WASHC5; LOW QUALITY PROTEIN: WASH complex subunit 5 [KO:K18464]
102514660  WASHC2A; WASH complex subunit 2 isoform X1 [KO:K18462]
102522882  WASHC1; WASH complex subunit 1 [KO:K18461]
102508135  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
102518518  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
102511599  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
102507351  CAPZB; F-actin-capping protein subunit beta isoform X4 [KO:K10365]
102507938  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
102510367  VPS26A; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
102520028  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
102511917  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
102521093  SNX3; sorting nexin-3 [KO:K17918]
102521026  SNX12; sorting nexin-12 isoform X1 [KO:K17918]
102516443  USP8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
102523549  STAMBP; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
102522214  RAB7A; ras-related protein Rab-7a [KO:K07897]
102522502  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
102518495  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
102523294  STAM; signal transducing adapter molecule 1 [KO:K04705]
102509976  TSG101; tumor susceptibility gene 101 protein [KO:K12183]
102523279  MVB12A; multivesicular body subunit 12A [KO:K12186]
102513605  MVB12B; multivesicular body subunit 12B isoform X1 [KO:K12186]
102506322  VPS28; vacuolar protein sorting-associated protein 28 homolog isoform X1 [KO:K12184]
102523237  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
102506567  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
102523482  VPS37C; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
102522705  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
102512652  SNF8; vacuolar-sorting protein SNF8 [KO:K12188]
102506627  VPS36; vacuolar protein-sorting-associated protein 36 isoform X1 [KO:K12190]
102516658  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
102504888  CHMP6; charged multivesicular body protein 6 isoform X1 [KO:K12195]
102518345  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
102506029  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
102513259  LOW QUALITY PROTEIN: charged multivesicular body protein 3 [KO:K12193]
102519417  CHMP2A; charged multivesicular body protein 2a isoform X1 [KO:K12191]
102510627  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
102507349  CHMP7; charged multivesicular body protein 7 [KO:K15053]
102516856  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
102524343  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
102505550  VTA1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
102523423  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
102512748  charged multivesicular body protein 1b-2 isoform X1 [KO:K12197]
102513197  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
102518114  CHMP5; charged multivesicular body protein 5 [KO:K12198]
102515266  IST1; IST1 homolog isoform X1 [KO:K19476]
102512712  PDCD6IP; LOW QUALITY PROTEIN: programmed cell death 6-interacting protein [KO:K12200]
102510616  SPG21; maspardin [KO:K19367]
102520978  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
102507610  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
102511410  SNX2; sorting nexin-2 isoform X1 [KO:K17917]
102514568  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
102513486  SNX32; sorting nexin-32 isoform X7 [KO:K17920]
102518681  SNX6; sorting nexin-6 [KO:K17920]
102520048  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102524334  HRAS; GTPase HRas isoform X1 [KO:K02833]
102520401  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
102524470  IL2RB; LOW QUALITY PROTEIN: interleukin-2 receptor subunit beta [KO:K05069]
102507993  RHOA; transforming protein RhoA [KO:K04513]
102504730  patr class I histocompatibility antigen, B-1 alpha chain isoform X1 [KO:K06751]
102507402  H-2 class I histocompatibility antigen, Q10 alpha chain [KO:K06751]
102508006  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102516242  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
102517613  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
106730534  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
116658362  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
116658363  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
102517702  folate receptor alpha-like [KO:K13649]
102517455  folate receptor beta isoform X1 [KO:K13649]
102503556  CAV1; caveolin-1 isoform X3 [KO:K06278]
102524490  CAV2; caveolin-2 isoform X1 [KO:K12958]
102509085  CAV3; caveolin-3 [KO:K12959]
102523322  EHD3; EH domain-containing protein 3 [KO:K12476]
102516841  EHD4; EH domain-containing protein 4 [KO:K12477]
102518430  EEA1; LOW QUALITY PROTEIN: early endosome antigen 1 [KO:K12478]
102515139  RAB5A; ras-related protein Rab-5A [KO:K07887]
102505264  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
102510298  RAB5C; ras-related protein Rab-5C [KO:K07889]
102511679  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
102519629  RBSN; rabenosyn-5 [KO:K12481]
102513959  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
102520956  RUFY1; RUN and FYVE domain-containing protein 1 [KO:K12482]
102512845  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
102521550  EHD1; LOW QUALITY PROTEIN: EH domain-containing protein 1 [KO:K12483]
102515198  LOW QUALITY PROTEIN: EH domain-containing protein 1 [KO:K12483]
102503767  VPS45; vacuolar protein sorting-associated protein 45 isoform X3 [KO:K12479]
102518014  SNX4; sorting nexin-4 [KO:K17919]
102511571  RAB22A; ras-related protein Rab-22A isoform X1 [KO:K07891]
116659581  RAB31; ras-related protein Rab-31 [KO:K07891]
102516389  RAB10; ras-related protein Rab-10 [KO:K07903]
102517974  RAB8A; ras-related protein Rab-8A [KO:K07901]
102511524  RAB35; ras-related protein Rab-35 isoform X1 [KO:K07876]
102515084  RAB11A; ras-related protein Rab-11A [KO:K07904]
102512209  RAB11B; ras-related protein Rab-11B [KO:K07905]
102504296  RAB11FIP5; LOW QUALITY PROTEIN: rab11 family-interacting protein 5 [KO:K12484]
102518032  RAB11FIP1; rab11 family-interacting protein 1 isoform X3 [KO:K12484]
102520164  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
102511315  ZFYVE27; protrudin isoform X3 [KO:K19368]
102518661  KIF5A; kinesin heavy chain isoform X3 [KO:K10396]
102517013  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
102519328  KIF5C; kinesin heavy chain [KO:K10396]
102507549  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
106729652  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
116660476  LOW QUALITY PROTEIN: rab11 family-interacting protein 4-like [KO:K12485]
102507360  partitioning defective 3 homolog isoform X1 [KO:K04237]
102520792  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
102524518  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
102522569  PARD6G; partitioning defective 6 homolog gamma isoform X1 [KO:K06093]
102509870  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
102522492  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
102514486  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102518702  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
102504160  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
102506915  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
102514698  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
102521511  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
102515038  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
102519237  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
102518968  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
102504624  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
102507752  ACAP2; LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [KO:K12489]
102507776  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
102519349  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
102511883  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
102521211  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
102509453  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
102508117  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
102517332  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
102517996  ARFGAP3; LOW QUALITY PROTEIN: ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
102523023  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X3 [KO:K12493]
102505649  PSD2; PH and SEC7 domain-containing protein 2 isoform X4 [KO:K12494]
102511310  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
102516363  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
102514656  PSD3; LOW QUALITY PROTEIN: PH and SEC7 domain-containing protein 3 [KO:K12494]
102523133  IQSEC3; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 3 [KO:K12495]
102507597  IQSEC1; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 1 [KO:K12495]
102505163  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
102510790  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
102510812  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
102518880  CYTH4; cytohesin-4 [KO:K18441]
102523236  CYTH2; cytohesin-2 [KO:K18441]
102510510  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
102520070  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X2 [KO:K18442]
102515339  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X6 [KO:K18443]
102511292  ARF1; ADP-ribosylation factor 1 [KO:K07937]
102507577  ADP-ribosylation factor 2 [KO:K07937]
102505892  ADP-ribosylation factor 1-like [KO:K07937]
102521537  ARF3; ADP-ribosylation factor 3 [KO:K07938]
102517818  LOW QUALITY PROTEIN: ADP-ribosylation factor 4-like [KO:K07939]
102515941  ARF4; ADP-ribosylation factor 4 [KO:K07939]
102508858  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
cfr04060  Cytokine-cytokine receptor interaction
cfr04070  Phosphatidylinositol signaling system
cfr04130  SNARE interactions in vesicular transport
cfr04142  Lysosome
cfr04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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