KEGG   PATHWAY: cgib00982
Entry
cgib00982                   Pathway                                
Name
Drug metabolism - cytochrome P450 - Carassius gibelio (silver crucian carp)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
cgib00982  Drug metabolism - cytochrome P450
cgib00982

Organism
Carassius gibelio (silver crucian carp) [GN:cgib]
Gene
127983569  flavin-containing monooxygenase 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
127938569  flavin-containing monooxygenase 5-like isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
127938570  flavin-containing monooxygenase 5-like isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
127938572  flavin-containing monooxygenase 5-like isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
127984273  flavin-containing monooxygenase 5-like isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
127970546  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
127970790  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
127962947  glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
127963074  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
127963076  glutathione S-transferase mu tandem duplicate 3 [KO:K00799] [EC:2.5.1.18]
127956643  microsomal glutathione S-transferase 1.1 [KO:K00799] [EC:2.5.1.18]
127956644  microsomal glutathione S-transferase 1.2 [KO:K00799] [EC:2.5.1.18]
127957338  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
127935227  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127969658  glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
127941348  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
127969936  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
127978687  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127978688  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
128014238  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
127984541  microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
127986609  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
128025910  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
128026206  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
128026562  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
128018639  glutathione S-transferase Mu 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
128027540  microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
127971698  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
128027703  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
127975161  glutathione S-transferase kappa 1-like isoform X1 [KO:K13299] [EC:2.5.1.18]
127975162  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
127975247  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
128030575  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
127971450  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
127971510  zgc:77938; alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
127971511  alcohol dehydrogenase class-3-like isoform X1 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
127934282  alcohol dehydrogenase 1-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
127970195  alcohol dehydrogenase 1-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
127970196  alcohol dehydrogenase 1-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
128026349  alcohol dehydrogenase 1-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
128027309  alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
128027495  alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
127952931  aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
127965135  amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
128021321  probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
128019948  amine oxidase [flavin-containing]-like [KO:K00274] [EC:1.4.3.4]
127942713  aldehyde oxidase 6 [KO:K00157] [EC:1.2.3.1]
127987425  aldehyde oxidase 5 [KO:K00157] [EC:1.2.3.1]
127963576  UDP glucuronosyltransferase 5 family, polypeptide E1 [KO:K00699] [EC:2.4.1.17]
127983785  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127965067  UDP-glucuronosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127945932  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
127934383  UDP glucuronosyltransferase 5 family, polypeptide F1 [KO:K00699] [EC:2.4.1.17]
127946746  UDP-glucuronosyltransferase 2A3-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127966413  UDP glucuronosyltransferase 5 family, polypeptide D1 [KO:K00699] [EC:2.4.1.17]
127957849  UDP glucuronosyltransferase 2 family, polypeptide B6 isoform X1 [KO:K00699] [EC:2.4.1.17]
127948591  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127948593  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
127958781  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
127968247  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127968249  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
127961342  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
128021231  UDP glucuronosyltransferase 5 family, polypeptide G2 [KO:K00699] [EC:2.4.1.17]
128014293  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128014294  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
128014523  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128022217  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128017171  UDP glucuronosyltransferase 5 family, polypeptide G1 [KO:K00699] [EC:2.4.1.17]
127990013  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127990069  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
127990085  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128018871  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
128019681  UDP-glucuronosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
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