KEGG   PATHWAY: copr00010
Entry
copr00010                   Pathway                                
Name
Glycolysis / Gluconeogenesis - Coprobacter secundus subsp. similis
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
copr00010  Glycolysis / Gluconeogenesis
copr00010

Module
copr_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:copr00010]
copr_M00002  Glycolysis, core module involving three-carbon compounds [PATH:copr00010]
copr_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:copr00010]
copr_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:copr00010]
Other DBs
GO: 0006096 0006094
Organism
Coprobacter secundus subsp. similis [GN:copr]
Gene
Cop2CBH44_19020  glucokinase [KO:K25026] [EC:2.7.1.2]
Cop2CBH44_27610  sugar kinase [KO:K25026] [EC:2.7.1.2]
Cop2CBH44_17310  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
Cop2CBH44_18170  pfkA; ATP-dependent 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
Cop2CBH44_14640  pfp; pyrophosphate--fructose 6-phosphate 1-phosphotransferase [KO:K00895] [EC:2.7.1.90]
Cop2CBH44_28590  fbp; fructose-1,6-bisphosphatase class 3 [KO:K04041] [EC:3.1.3.11]
Cop2CBH44_09100  fructose-bisphosphate aldolase [KO:K11645] [EC:4.1.2.13]
Cop2CBH44_29080  fbaA; fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
Cop2CBH44_18500  fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
Cop2CBH44_09740  tpiA; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
Cop2CBH44_19540  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
Cop2CBH44_06950  pgk; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
Cop2CBH44_03540  gpmA_1; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
Cop2CBH44_04290  gpmA_2; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
Cop2CBH44_24710  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
Cop2CBH44_26520  cofactor-independent phosphoglycerate mutase [KO:K15635] [EC:5.4.2.12]
Cop2CBH44_10910  eno_1; enolase [KO:K01689] [EC:4.2.1.11]
Cop2CBH44_20760  eno_2; enolase [KO:K01689] [EC:4.2.1.11]
Cop2CBH44_21750  pyruvate kinase [KO:K00873] [EC:2.7.1.40]
Cop2CBH44_10060  pyruvate, phosphate dikinase [KO:K01006] [EC:2.7.9.1]
Cop2CBH44_15280  pyruvate-flavodoxin oxidoreductase [KO:K03737] [EC:1.2.7.1 1.2.7.-]
Cop2CBH44_09980  3-methyl-2-oxobutanoate dehydrogenase subunit VorB [KO:K00174] [EC:1.2.7.3 1.2.7.11]
Cop2CBH44_24260  MFS transporter [KO:K00174] [EC:1.2.7.3 1.2.7.11]
Cop2CBH44_09990  2-oxoglutarate oxidoreductase [KO:K00175] [EC:1.2.7.3 1.2.7.11]
Cop2CBH44_24270  2-oxoglutarate ferredoxin oxidoreductase subunit beta [KO:K00175] [EC:1.2.7.3 1.2.7.11]
Cop2CBH44_00670  aldH; aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
Cop2CBH44_18350  acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
Cop2CBH44_21990  acetyl-CoA synthetase [KO:K24012] [EC:6.2.1.13]
Cop2CBH44_28650  aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
Cop2CBH44_31880  aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
Cop2CBH44_32260  aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
Cop2CBH44_04250  aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
Cop2CBH44_24620  haloacid dehalogenase [KO:K20866] [EC:3.1.3.10]
Cop2CBH44_10560  phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
Cop2CBH44_31310  pckA_2; phosphoenolpyruvate carboxykinase [KO:K01610] [EC:4.1.1.49]
Cop2CBH44_23550  pckA_1; phosphoenolpyruvate carboxykinase [KO:K01610] [EC:4.1.1.49]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
copr00020  Citrate cycle (TCA cycle)
copr00030  Pentose phosphate pathway
copr00500  Starch and sucrose metabolism
copr00620  Pyruvate metabolism
copr00640  Propanoate metabolism
copr00710  Carbon fixation by Calvin cycle
KO pathway
ko00010   
LinkDB

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