Entry
Symbol
TPI, tpiA
Name
triosephosphate isomerase (TIM) [EC:
5.3.1.1 ]
Pathway
map00051 Fructose and mannose metabolism
map00710 Carbon fixation by Calvin cycle
map01110 Biosynthesis of secondary metabolites
map01120 Microbial metabolism in diverse environments
Module
M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
M00002 Glycolysis, core module involving three-carbon compounds
M00003 Gluconeogenesis, oxaloacetate => fructose-6P
M00165 Reductive pentose phosphate cycle (Calvin cycle)
Reaction
R01015 D-glyceraldehyde-3-phosphate aldose-ketose-isomerase
Disease
H00664 Anemia due to disorders of glycolytic enzymes
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
K01803 TPI, tpiA; triosephosphate isomerase (TIM)
00051 Fructose and mannose metabolism
K01803 TPI, tpiA; triosephosphate isomerase (TIM)
00562 Inositol phosphate metabolism
K01803 TPI, tpiA; triosephosphate isomerase (TIM)
09102 Energy metabolism
00710 Carbon fixation by Calvin cycle
K01803 TPI, tpiA; triosephosphate isomerase (TIM)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome
K01803 TPI, tpiA; triosephosphate isomerase (TIM)
Enzymes [BR:ko01000 ]
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.1 Interconverting aldoses and ketoses, and related compounds
5.3.1.1 triose-phosphate isomerase
K01803 TPI, tpiA; triosephosphate isomerase (TIM)
Exosome [BR:ko04147 ]
Exosomal proteins
Exosomal proteins of colorectal cancer cells
K01803 TPI, tpiA; triosephosphate isomerase (TIM)
Exosomal proteins of bladder cancer cells
K01803 TPI, tpiA; triosephosphate isomerase (TIM)
Exosomal proteins of melanoma cells
K01803 TPI, tpiA; triosephosphate isomerase (TIM)
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Genes
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Taxonomy UniProt
Reference
Authors
Pichersky E, Gottlieb LD, Hess JF
Title
Nucleotide sequence of the triose phosphate isomerase gene of Escherichia coli.
Journal
Sequence
Reference
Authors
Daar IO, Artymiuk PJ, Phillips DC, Maquat LE
Title
Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme.
Journal
Reference
Authors
Schurig H, Beaucamp N, Ostendorp R, Jaenicke R, Adler E, Knowles JR
Title
Phosphoglycerate kinase and triosephosphate isomerase from the hyperthermophilic bacterium Thermotoga maritima form a covalent bifunctional enzyme complex.
Journal
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