KEGG PATHWAY: crg00730

KEGG

PATHWAY: crg00730

Entry

crg00730                    Pathway

Name

Thiamine metabolism - Magallana gigas (Pacific oyster)

Class

Metabolism; Metabolism of cofactors and vitamins

Pathway map

Thiamine metabolism

Other DBs

GO:

Organism

Magallana gigas (Pacific oyster) [GN:crg]

Gene

cysteine desulfurase, mitochondrial [KO:K04487] [EC:2.8.1.7]

cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]

alkaline phosphatase, tissue-nonspecific isozyme [KO:K01077] [EC:3.1.3.1]

alkaline phosphatase [KO:K01077] [EC:3.1.3.1]

alkaline phosphatase [KO:K01077] [EC:3.1.3.1]

alkaline phosphatase, tissue-nonspecific isozyme [KO:K01077] [EC:3.1.3.1]

alkaline phosphatase [KO:K01077] [EC:3.1.3.1]

alkaline phosphatase [KO:K01077] [EC:3.1.3.1]

alkaline phosphatase [KO:K01077] [EC:3.1.3.1]

LOW QUALITY PROTEIN: alkaline phosphatase, tissue-nonspecific isozyme [KO:K01077] [EC:3.1.3.1]

low molecular weight phosphotyrosine protein phosphatase 1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]

low molecular weight phosphotyrosine protein phosphatase-like [KO:K14394] [EC:3.1.3.2 3.1.3.48]

thiamin pyrophosphokinase 1 isoform X1 [KO:K00949] [EC:2.7.6.2]

adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]

adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]

adenylate kinase 2, mitochondrial [KO:K00939] [EC:2.7.4.3]

Compound

NAD+

Pyridoxal phosphate

Pyruvate

Glycine

Thiamin diphosphate

L-Tyrosine

L-Cysteine

D-Glyceraldehyde 3-phosphate

Thiamine

Thiamin monophosphate

4-Amino-5-hydroxymethyl-2-methylpyrimidine

Thiamine acetic acid

Thiamin triphosphate

Aminoimidazole ribotide

5-(2-Hydroxyethyl)-4-methylthiazole

4-Methyl-5-(2-phosphooxyethyl)thiazole

4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine

4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate

Thiamine aldehyde

1-Deoxy-D-xylulose 5-phosphate

Iminoglycine

Sulfur-carrier protein

[Enzyme]-cysteine

[Enzyme]-S-sulfanylcysteine

Adenylyl-[sulfur-carrier protein]

Thiocarboxy-[sulfur-carrier protein]

N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine

2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate

2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate

4-Amino-5-aminomethyl-2-methylpyrimidine

ADP-5-ethyl-4-methylthiazole-2-carboxylate

Reference

Authors

Kawasaki Y, Onozuka M, Mizote T, Nosaka K.

Title

Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.

Journal

Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x

Reference

Authors

Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.

Title

Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).

Journal

Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z

Reference

Authors

Begley TP, Ealick SE, McLafferty FW

Title

Thiamin biosynthesis: still yielding fascinating biological chemistry.

Journal

Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084

Reference

Authors

Wightman R, Meacock PA

Title

The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.

Journal

Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0

Reference

Authors

Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP

Title

Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.

Journal

Nature 478:542-6 (2011)
DOI:10.1038/nature10503

Reference

Authors

Jurgenson CT, Begley TP, Ealick SE

Title

The structural and biochemical foundations of thiamin biosynthesis.

Journal

Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340

Related
pathway

Glycolysis / Gluconeogenesis

Purine metabolism

Glycine, serine and threonine metabolism

Cysteine and methionine metabolism

Phenylalanine, tyrosine and tryptophan biosynthesis

Vitamin B6 metabolism

KO pathway

LinkDB

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