Entry Name Thiamine metabolism
Class Metabolism; Metabolism of cofactors and vitaminsBRITE hierarchy
Pathway map Module M00127 Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP [PATH:ko00730 ]
M00895 Thiamine biosynthesis, prokaryotes, AIR (+ DXP/glycine) => TMP/TPP [PATH:ko00730 ]
M00896 Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP [PATH:ko00730 ]
M00897 Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP [PATH:ko00730 ]
M00898 Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP [PATH:ko00730 ]
Other DBs Orthology K00949 thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2 ]
K03146 THI4, THI1; cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60 ]
K03148 thiF; sulfur carrier protein ThiS adenylyltransferase [EC:2.7.7.73 ]
K03707 tenA; thiaminase (transcriptional activator TenA) [EC:3.5.99.2 ]
K06949 rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100 ]
K10810 tenI; thiazole tautomerase (transcriptional regulator TenI) [EC:5.3.99.10 ]
K14153 thiDE; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.1.49 2.7.4.7 2.5.1.3 ]
K18278 THI5; pyrimidine precursor biosynthesis enzyme
K20895 ylmB; formylaminopyrimidine deformylase [EC:3.5.1.-]
K20896 TENA_E; formylaminopyrimidine deformylase / aminopyrimidine aminohydrolase [EC:3.5.1.- 3.5.99.-]
K21219 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.1.49 2.7.4.7 2.5.1.3 ]
K22699 thi4; sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59 ]
K22911 TH2; thiamine phosphate phosphatase / amino-HMP aminohydrolase [EC:3.1.3.100 3.5.99.-]
K23458 PHO5_11_12; repressible acid phosphatase
Compound C00118 D-Glyceraldehyde 3-phosphate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03373 Aminoimidazole ribotide
C04294 5-(2-Hydroxyethyl)-4-methylthiazole
C04327 4-Methyl-5-(2-phosphooxyethyl)thiazole
C04556 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C11437 1-Deoxy-D-xylulose 5-phosphate
C15812 [Enzyme]-S-sulfanylcysteine
C15813 Adenylyl-[sulfur-carrier protein]
C15814 Thiocarboxy-[sulfur-carrier protein]
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20246 2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247 2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20267 4-Amino-5-aminomethyl-2-methylpyrimidine
C20784 ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference Authors Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
Title Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
Journal Reference Authors Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
Title Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
Journal Reference Authors Begley TP, Ealick SE, McLafferty FW
Title Thiamin biosynthesis: still yielding fascinating biological chemistry.
Journal Reference Authors Wightman R, Meacock PA
Title The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
Journal Reference Authors Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
Title Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
Journal Reference Authors Jurgenson CT, Begley TP, Ealick SE
Title The structural and biochemical foundations of thiamin biosynthesis.
Journal Related ko00010 Glycolysis / Gluconeogenesis
ko00260 Glycine, serine and threonine metabolism
ko00270 Cysteine and methionine metabolism
ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis
