KEGG PATHWAY: crg00260

PATHWAY: crg00260

Entry

crg00260                    Pathway

Name

Glycine, serine and threonine metabolism - Magallana gigas (Pacific oyster)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

crg00260

Glycine, serine and threonine metabolism

Module

crg_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:crg00260]

crg_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:crg00260]

crg_M00555

Betaine biosynthesis, choline => betaine [PATH:crg00260]

crg_M00621

Glycine cleavage system [PATH:crg00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Magallana gigas (Pacific oyster) [GN:crg]

Gene

105329466

probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

105323187

serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

105333843

serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]

105331916

serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

105341870

glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

105340243

glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

105343645

glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

105336882

LOW QUALITY PROTEIN: glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

105338913

glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

105331636

glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]

105347640

probable phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]

105337408

D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

105325247

phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]

105329938

phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]

105333195

2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

105329265

L-threonine 3-dehydrogenase, mitochondrial isoform X3 [KO:K15789] [EC:1.1.1.103]

105330021

5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]

105345865

Maoa; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]

105321028

probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]

105318480

amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]

105345900

LOW QUALITY PROTEIN: amine oxidase [flavin-containing]-like [KO:K00274] [EC:1.4.3.4]

105332360

membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]

105333668

glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

105333231

aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

117685666

aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]

105339502

dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

105338616

glycine cleavage system H protein [KO:K02437]

105322199

D-aspartate oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]

105346483

D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]

105338391

alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

105337749

uncharacterized protein LOC105337749 [KO:K00108] [EC:1.1.99.1]

105339123

uncharacterized protein LOC105339123 isoform X1 [KO:K00108] [EC:1.1.99.1]

105327683

alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

105318322

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

105339804

S-methylmethionine--homocysteine S-methyltransferase BHMT2 [KO:K00544] [EC:2.1.1.5]

105321531

peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

105321532

peroxisomal sarcosine oxidase isoform X2 [KO:K00306] [EC:1.5.3.1 1.5.3.7]

105328860

peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

105328862

peroxisomal sarcosine oxidase isoform X2 [KO:K00306] [EC:1.5.3.1 1.5.3.7]

105336612

cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]

105327873

cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

105331397

L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]

105345373

serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

105345374

serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

117681903

D-threo-3-hydroxyaspartate dehydratase-like isoform X1 [KO:K20498] [EC:4.3.1.18]

105327847

serine racemase [KO:K12235] [EC:5.1.1.18]

105328907

L-threonine ammonia-lyase [KO:K12235] [EC:5.1.1.18]

105327858

serine racemase-like isoform X1 [KO:K12235] [EC:5.1.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721