KEGG   PATHWAY: csab04721
Entry
csab04721                   Pathway                                
Name
Synaptic vesicle cycle - Chlorocebus sabaeus (green monkey)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
Pathway map
csab04721  Synaptic vesicle cycle
csab04721

Other DBs
GO: 0016079 0048488
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103214932  SLC6A3; solute carrier family 6 member 3 [KO:K05036]
103215141  SLC1A3; solute carrier family 1 member 3 [KO:K05614]
103215416  SLC18A1; solute carrier family 18 member A1 [KO:K08155]
103215418  ATP6V1B2; ATPase H+ transporting V1 subunit B2 [KO:K02147]
103215553  TCIRG1; T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [KO:K02154]
103215828  SLC18A3; solute carrier family 18 member A3 [KO:K14636]
103216582  SLC18A2; solute carrier family 18 member A2 [KO:K08155]
103218348  SLC6A12; solute carrier family 6 member 12 [KO:K05045]
103218350  SLC6A13; solute carrier family 6 member 13 [KO:K05046]
103218965  ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
103219194  CLTA; clathrin light chain A [KO:K04644]
103219228  UNC13B; unc-13 homolog B [KO:K15293]
103219505  SLC1A1; solute carrier family 1 member 1 [KO:K05612]
103220084  ATP6V1B1; ATPase H+ transporting V1 subunit B1 [KO:K02147]
103220345  ATP6V1E2; ATPase H+ transporting V1 subunit E2 [KO:K02150]
103220817  ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
103221144  AP2M1; adaptor related protein complex 2 mu 1 subunit [KO:K11826]
103221223  [KO:K13504]
103221492  [KO:K02155]
103221764  ATP6V1G2; ATPase H+ transporting V1 subunit G2 [KO:K02152]
103222872  ATP6V1E1; ATPase H+ transporting V1 subunit E1 [KO:K02150]
103223009  CLTCL1; clathrin heavy chain like 1 [KO:K04646]
103224796  SLC1A7; solute carrier family 1 member 7 [KO:K05618]
103224950  SLC6A9; solute carrier family 6 member 9 [KO:K05038]
103224952  ATP6V0B; ATPase H+ transporting V0 subunit b [KO:K03661]
103226843  ATP6V0C; ATPase H+ transporting V0 subunit c [KO:K02155]
103226868  ATP6V1F; ATPase H+ transporting V1 subunit F [KO:K02151]
103227203  ATP6V0E2; ATPase H+ transporting V0 subunit e2 [KO:K02153]
103227405  ATP6V0A4; ATPase H+ transporting V0 subunit a4 [KO:K02154]
103228009  SLC6A11; solute carrier family 6 member 11 [KO:K05044]
103228010  SLC6A1; solute carrier family 6 member 1 [KO:K05034]
103228299  ATP6V1A; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:7.1.2.2]
103229206  ATP6V1D; ATPase H+ transporting V1 subunit D [KO:K02149]
103230366  ATP6V1G3; ATPase H+ transporting V1 subunit G3 [KO:K02152]
103230583  DNM3; dynamin 3 [KO:K01528] [EC:3.6.5.5]
103231186  STX1B; syntaxin 1B [KO:K08486]
103233011  SLC6A2; solute carrier family 6 member 2 [KO:K05035]
103233279  ATP6V0D1; ATPase H+ transporting V0 subunit d1 [KO:K02146]
103233911  DNM2; dynamin 2 [KO:K23484]
103234051  SLC1A6; solute carrier family 1 member 6 [KO:K05617]
103234148  UNC13A; unc-13 homolog A [KO:K15293]
103234170  RAB3A; RAB3A, member RAS oncogene family [KO:K07882]
103234371  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
103234845  STX3; syntaxin 3 [KO:K08486]
103234926  [KO:K11827]
103234945  NAPA; NSF attachment protein alpha [KO:K15296]
103235034  SLC17A7; solute carrier family 17 member 7 [KO:K12302]
103235185  AP2A2; adaptor related protein complex 2 alpha 2 subunit [KO:K11824]
103235522  AP2S1; adaptor related protein complex 2 sigma 1 subunit [KO:K11827]
103235543  AP2A1; adaptor related protein complex 2 alpha 1 subunit [KO:K11824]
103236797  ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
103237075  ATP6V0D2; ATPase H+ transporting V0 subunit d2 [KO:K02146]
103237247  ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
103237679  SLC1A2; solute carrier family 1 member 2 [KO:K05613]
103238778  SYT1; synaptotagmin 1 [KO:K15290]
103238798  SLC17A6; solute carrier family 17 member 6 [KO:K12302]
103238874  SLC6A5; solute carrier family 6 member 5 [KO:K05038]
103238934  SLC17A8; solute carrier family 17 member 8 [KO:K12302]
103239340  ATP6V0A2; ATPase H+ transporting V0 subunit a2 [KO:K02154]
103239406  STX2; syntaxin 2 [KO:K08486]
103239541  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
103239806  DNM1; dynamin 1 [KO:K01528] [EC:3.6.5.5]
103239836  STXBP1; syntaxin binding protein 1 [KO:K15292]
103242343  VAMP2; vesicle associated membrane protein 2 [KO:K13504]
103242661  SLC6A4; solute carrier family 6 member 4 [KO:K05037]
103242741  AP2B1; adaptor related protein complex 2 beta 1 subunit [KO:K11825]
103242823  CLTC; clathrin heavy chain [KO:K04646]
103243257  NSF; N-ethylmaleimide sensitive factor, vesicle fusing ATPase [KO:K06027] [EC:3.6.4.6]
103243409  ATP6V0A1; ATPase H+ transporting V0 subunit a1 [KO:K02154]
103243917  RIMS1; regulating synaptic membrane exocytosis 1 [KO:K15291]
103244200  CPLX4; complexin 4 [KO:K15295]
103244791  SLC6A7; solute carrier family 6 member 7 [KO:K05040]
103244984  ATP6V0E1; ATPase H+ transporting V0 subunit e1 [KO:K02153]
103245019  CPLX2; complexin 2 [KO:K15294]
103245028  CLTB; clathrin light chain B [KO:K04645]
103245327  CPLX3; complexin 3 [KO:K15295]
103245596  UNC13C; unc-13 homolog C [KO:K15293]
103246166  SLC32A1; solute carrier family 32 member 1 [KO:K15015]
103246502  SNAP25; synaptosome associated protein 25 [KO:K18211]
103246513  CPLX1; complexin 1 [KO:K15294]
103246629  STX1A; syntaxin 1A [KO:K04560]
Compound
C00002  ATP
C00025  L-Glutamate
C00037  Glycine
C00076  Calcium cation
C00080  H+
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00780  Serotonin
C01996  Acetylcholine
C03758  Dopamine
C16041  Leu-enkephalin
Reference
PMID:12827282
  Authors
Li L, Chin LS
  Title
The molecular machinery of synaptic vesicle exocytosis.
  Journal
Cell Mol Life Sci 60:942-60 (2003)
DOI:10.1007/s00018-003-2240-7
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
PMID:18275379
  Authors
Chapman ER
  Title
How does synaptotagmin trigger neurotransmitter release?
  Journal
Annu Rev Biochem 77:615-41 (2008)
DOI:10.1146/annurev.biochem.77.062005.101135
Reference
PMID:10212473
  Authors
Benfenati F, Onofri F, Giovedi S
  Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
  Journal
Philos Trans R Soc Lond B Biol Sci 354:243-57 (1999)
DOI:10.1098/rstb.1999.0376
Reference
PMID:20634814
  Authors
de Saint Basile G, Menasche G, Fischer A
  Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
  Journal
Nat Rev Immunol 10:568-79 (2010)
DOI:10.1038/nri2803
Reference
PMID:17767192
  Authors
Carr CM, Munson M
  Title
Tag team action at the synapse.
  Journal
EMBO Rep 8:834-8 (2007)
DOI:10.1038/sj.embor.7401051
Reference
PMID:15217342
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle.
  Journal
Annu Rev Neurosci 27:509-47 (2004)
DOI:10.1146/annurev.neuro.26.041002.131412
Reference
PMID:12563290
  Authors
Gundelfinger ED, Kessels MM, Qualmann B
  Title
Temporal and spatial coordination of exocytosis and endocytosis.
  Journal
Nat Rev Mol Cell Biol 4:127-39 (2003)
DOI:10.1038/nrm1016
Reference
PMID:16990140
  Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
  Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
  Journal
Cell 126:1175-87 (2006)
DOI:10.1016/j.cell.2006.08.030
Reference
PMID:12094216
  Authors
Chapman ER
  Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
  Journal
Nat Rev Mol Cell Biol 3:498-508 (2002)
DOI:10.1038/nrm855
Reference
PMID:7791897
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
  Journal
Nature 375:645-53 (1995)
DOI:10.1038/375645a0
Reference
PMID:12154365
  Authors
Rizo J, Sudhof TC
  Title
Snares and Munc18 in synaptic vesicle fusion.
  Journal
Nat Rev Neurosci 3:641-53 (2002)
DOI:10.1038/nrn898
Reference
PMID:18726177
  Authors
Malsam J, Kreye S, Sollner TH
  Title
Membrane fusion: SNAREs and regulation.
  Journal
Cell Mol Life Sci 65:2814-32 (2008)
DOI:10.1007/s00018-008-8352-3
Related
pathway
csab04144  Endocytosis
csab04724  Glutamatergic synapse
csab04725  Cholinergic synapse
csab04726  Serotonergic synapse
csab04727  GABAergic synapse
csab04728  Dopaminergic synapse
KO pathway
ko04721   

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