KEGG   PATHWAY: csab04726
Entry
csab04726                   Pathway                                
Name
Serotonergic synapse - Chlorocebus sabaeus (green monkey)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
csab04726  Serotonergic synapse
csab04726

Other DBs
GO: 0007210
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103214396  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
103215416  SLC18A1; solute carrier family 18 member A1 [KO:K08155]
103215810  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
103216240  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
103216299  CYP2C19; cytochrome P450 family 2 subfamily C member 19 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
103216300  CYP2C18; cytochrome P450 family 2 subfamily C member 18 [KO:K17720] [EC:1.14.14.1]
103216301  CYP2C9; cytochrome P450 family 2 subfamily C member 9 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
103216303  CYP2C8; cytochrome P450 family 2 subfamily C member 8 [KO:K17718] [EC:1.14.14.1]
103216308  [KO:K17718] [EC:1.14.14.1]
103216582  SLC18A2; solute carrier family 18 member A2 [KO:K08155]
103216942  [KO:K04161]
103217112  KCNJ3; potassium voltage-gated channel subfamily J member 3 [KO:K04997]
103217727  APP; amyloid beta precursor protein [KO:K04520]
103218049  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
103218385  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
103218476  GNB3; G protein subunit beta 3 [KO:K07825]
103218752  KCNJ6; potassium voltage-gated channel subfamily J member 6 [KO:K05000]
103218763  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103218776  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103218890  PTGS1; prostaglandin-endoperoxide synthase 1 [KO:K00509] [EC:1.14.99.1]
103219014  GNG10; G protein subunit gamma 10 [KO:K04545]
103219549  PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
103219624  GNAQ; G protein subunit alpha q [KO:K04634]
103221147  HTR3E; 5-hydroxytryptamine receptor 3E [KO:K04819]
103221150  HTR3D; 5-hydroxytryptamine receptor 3D [KO:K04819]
103221209  GNB4; G protein subunit beta 4 [KO:K04538]
103221320  HTR3C; 5-hydroxytryptamine receptor 3C [KO:K04819]
103221654  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103222225  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
103222941  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103223410  [KO:K17712] [EC:1.14.14.1]
103223412  [KO:K17712] [EC:1.14.14.1]
103223740  KCNJ9; potassium voltage-gated channel subfamily J member 9 [KO:K05002]
103224167  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103224284  GNAI3; G protein subunit alpha i3 [KO:K04630]
103224540  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103224649  GNG12; G protein subunit gamma 12 [KO:K04347]
103224719  CYP2J2; cytochrome P450 family 2 subfamily J member 2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
103224873  CYP4X1; cytochrome P450 family 4 subfamily X member 1 [KO:K07428] [EC:1.14.14.1]
103225402  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
103225471  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
103225777  GNB1; G protein subunit beta 1 [KO:K04536]
103226076  DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
103226542  [KO:K04546]
103226652  GNAI1; G protein subunit alpha i1 [KO:K04630]
103226786  KCND2; potassium voltage-gated channel subfamily D member 2 [KO:K04892]
103227022  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103227281  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
103227664  GNAI2; G protein subunit alpha i2 [KO:K04630]
103227762  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
103227941  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103228031  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103228169  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
103228537  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
103228983  GNG2; G protein subunit gamma 2 [KO:K07826]
103229829  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103230339  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
103230418  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
103230420  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
103230532  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103231841  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
103231842  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
103231895  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
103231971  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
103232513  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
103233012  GNAO1; G protein subunit alpha o1 [KO:K04534]
103233299  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
103233652  GNG7; G protein subunit gamma 7 [KO:K04543]
103233940  GNG3; G protein subunit gamma 3 [KO:K04540]
103234371  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
103234377  [KO:K04345] [EC:2.7.11.11]
103234920  GNG8; G protein subunit gamma 8 [KO:K04544]
103235232  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
103235528  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
103236336  GNG5; G protein subunit gamma 5 [KO:K04542]
103236614  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103238211  RAPGEF3; Rap guanine nucleotide exchange factor 3 [KO:K08014]
103238730  TPH2; tryptophan hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
103239320  TPH1; tryptophan hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
103239541  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
103239954  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
103240053  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
103241552  TRPC1; transient receptor potential cation channel subfamily C member 1 [KO:K04964]
103242192  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
103242262  [KO:K00458] [EC:1.13.11.31]
103242265  ALOX12; arachidonate 12-lipoxygenase, 12S type [KO:K00458] [EC:1.13.11.31]
103242336  ALOX15B; arachidonate 15-lipoxygenase, type B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
103242337  ALOX12B; arachidonate 12-lipoxygenase, 12R type [KO:K08021] [EC:1.13.11.-]
103242661  SLC6A4; solute carrier family 6 member 4 [KO:K05037]
103243171  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103243499  [KO:K04632]
103243509  GNAS; GNAS complex locus [KO:K04632]
103243636  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
103244350  KCNN2; potassium calcium-activated channel subfamily N member 2 [KO:K04943]
103244768  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
103244912  GABRB2; gamma-aminobutyric acid type A receptor beta2 subunit [KO:K05181]
103244980  DUSP1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
103245451  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103245611  GNB5; G protein subunit beta 5 [KO:K04539]
103245774  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
103245776  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
103245777  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
103245842  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
103246008  GABRB3; gamma-aminobutyric acid type A receptor beta3 subunit [KO:K05181]
103246100  PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
103246145  GABRB1; gamma-aminobutyric acid type A receptor beta1 subunit [KO:K05181]
103246363  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103246591  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
103246657  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
103246723  GNB2; G protein subunit beta 2 [KO:K04537]
103248501  HTR3B; 5-hydroxytryptamine receptor 3B [KO:K04819]
103248502  HTR3A; 5-hydroxytryptamine receptor 3A [KO:K04819]
103248811  KCNJ5; potassium voltage-gated channel subfamily J member 5 [KO:K04999]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
csab00380  Tryptophan metabolism
csab00590  Arachidonic acid metabolism
csab04020  Calcium signaling pathway
csab04721  Synaptic vesicle cycle
csab04976  Bile secretion
KO pathway
ko04726   

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