KEGG PATHWAY: csol04391

PATHWAY: csol04391

Entry

csol04391                   Pathway

Name

Hippo signaling pathway - fly - Ceratosolen solmsi marchali (fig wasp)

Description

Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size during development from flies to humans. The core of the drosophila pathway is a kinase cascade consisting of four proteins including Hippo, Salvador, Warts and Mats. Upon activation by stimuli such as high cell density in cell culture, the Hippo pathway kinase cascade phosphorylates and inhibits the transcriptional co-activator Yorkie, thereby promoting cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated, Yorkie translocates into the nucleus to bind to transcriptional factors to promote cell growth and proliferation.

Class

Environmental Information Processing; Signal transduction

Pathway map

csol04391

Hippo signaling pathway - fly

Other DBs

GO:

0035329

Organism

Ceratosolen solmsi marchali (fig wasp) [GN:csol]

Gene

105361013

LIX1-like protein [KO:K16673]

105366109

protein dachsous [KO:K16507]

105365395

cadherin-related tumor suppressor [KO:K16669]

105363674

cadherin-related tumor suppressor-like [KO:K16669]

105366972

casein kinase I isoform epsilon-like [KO:K08960] [EC:2.7.11.1]

105366667

arginine-glutamic acid dipeptide repeats protein [KO:K05628]

105367573

palmitoyltransferase ZDHHC18 [KO:K16675] [EC:2.3.1.225]

105366641

lipoma-preferred partner homolog isoform X1 [KO:K16676]

105363309

unconventional myosin-IXb [KO:K16677]

105359447

lethal(2) giant larvae protein homolog 1 [KO:K06094]

105363841

atypical protein kinase C [KO:K06069] [EC:2.7.11.13]

105364886

ras association domain-containing protein 2 [KO:K09851]

105368684

serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]

105364740

serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit [KO:K03456]

105361565

protein phosphatase PP2A 55 kDa regulatory subunit [KO:K04354]

105364894

uncharacterized protein LOC105364894 [KO:K16678]

105368830

stress-activated protein kinase JNK [KO:K04440] [EC:2.7.11.24]

105367423

hemicentin-2 isoform X1 [KO:K16680]

105359224

actin-5C [KO:K05692]

105368884

protein crumbs [KO:K16681]

105359501

partitioning defective 3 homolog [KO:K04237]

105363968

partitioning defective protein 6 isoform X1 [KO:K06093]

105363318

uncharacterized protein LOC105363318 [KO:K06091]

105359874

LIM domain-containing protein jub isoform X1 [KO:K16682]

105363000

protein lap4 [KO:K16175]

105368464

disks large 1 tumor suppressor protein-like [KO:K12076]

105367574

disks large homolog 5 [KO:K24050]

105364091

protein expanded [KO:K16683]

105365050

merlin isoform X1 [KO:K16684]

105366718

protein kibra [KO:K16685]

105364810

serine/threonine-protein kinase 3 [KO:K04412]

105361074

scaffold protein salvador-like [KO:K16686]

105363788

serine/threonine-protein kinase Warts [KO:K08791] [EC:2.7.11.1]

105363752

MOB kinase activator-like 1 [KO:K06685]

105364811

transcriptional coactivator yorkie isoform X1 [KO:K16687]

105363130

14-3-3 protein zeta isoform X1 [KO:K16197]

105366729

14-3-3 protein epsilon [KO:K06630]

105367805

protein mothers against dpp-like [KO:K04676]

105360280

protein mothers against dpp [KO:K04676]

105363728

protein scalloped isoform X1 [KO:K09448]

105360959

homeobox protein homothorax isoform X1 [KO:K16672]

105361015

G1/S-specific cyclin-E [KO:K06626]

105359323

serine/arginine repetitive matrix protein 1 [KO:K04377]

105367697

division abnormally delayed protein [KO:K02306]

105367696

protein Wnt-1 [KO:K03209]

105367252

protein vein isoform X1 [KO:K16690]

105364620

pro-neuregulin-3, membrane-bound isoform-like [KO:K16691]

Reference

PMID:21138973

Authors

Halder G, Johnson RL

Title

Hippo signaling: growth control and beyond.

Journal

Development 138:9-22 (2011)
DOI:10.1242/dev.045500

Reference

PMID:20439427

Authors

Zhao B, Li L, Lei Q, Guan KL

Title

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.

Journal

Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210

Reference

PMID:20951342

Authors

Pan D

Title

The hippo signaling pathway in development and cancer.

Journal

Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011

Reference

PMID:22750148

Authors

Schroeder MC, Halder G

Title

Regulation of the Hippo pathway by cell architecture and mechanical signals.

Journal

Semin Cell Dev Biol 23:803-11 (2012)
DOI:10.1016/j.semcdb.2012.06.001

Reference

PMID:21808241

Authors

Zhao B, Tumaneng K, Guan KL

Title

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.

Journal

Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303

Reference

PMID:22035868

Authors

Yin M, Zhang L

Title

Hippo signaling: a hub of growth control, tumor suppression and pluripotency maintenance.

Journal

J Genet Genomics 38:471-81 (2011)
DOI:10.1016/j.jgg.2011.09.009

Reference

PMID:20945341

Authors

Chan SW, Lim CJ, Chen L, Chong YF, Huang C, Song H, Hong W

Title

The Hippo pathway in biological control and cancer development.

Journal

J Cell Physiol 226:928-39 (2011)
DOI:10.1002/jcp.22435

Reference

PMID:21415026

Authors

Hilman D, Gat U

Title

The evolutionary history of YAP and the hippo/YAP pathway.

Journal

Mol Biol Evol 28:2403-17 (2011)
DOI:10.1093/molbev/msr065

Reference

PMID:18955139

Authors

Zhao B, Lei QY, Guan KL

Title

The Hippo-YAP pathway: new connections between regulation of organ size and cancer.

Journal

Curr Opin Cell Biol 20:638-46 (2008)
DOI:10.1016/j.ceb.2008.10.001

Reference

PMID:19846288

Authors

Badouel C, Garg A, McNeill H

Title

Herding Hippos: regulating growth in flies and man.

Journal

Curr Opin Cell Biol 21:837-43 (2009)
DOI:10.1016/j.ceb.2009.09.010

Reference

PMID:19164949

Authors

Zhang L, Yue T, Jiang J

Title

Hippo signaling pathway and organ size control.

Journal

Fly (Austin) 3:68-73 (2009)
DOI:10.4161/fly.3.1.7788

Reference

PMID:17318211

Authors

Harvey K, Tapon N

Title

The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network.

Journal

Nat Rev Cancer 7:182-91 (2007)
DOI:10.1038/nrc2070

Reference

PMID:19517570

Authors

Kango-Singh M, Singh A

Title

Regulation of organ size: insights from the Drosophila Hippo signaling pathway.

Journal

Dev Dyn 238:1627-37 (2009)
DOI:10.1002/dvdy.21996

Reference

PMID:21145886

Authors

Sun G, Irvine KD

Title

Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors.

Journal

Dev Biol 350:139-51 (2011)
DOI:10.1016/j.ydbio.2010.11.036

Reference

PMID:22830020

Authors

Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G

Title

Hippo and rassf1a Pathways: A Growing Affair.

Journal

Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628

Reference

PMID:20452772

Authors

Oh H, Irvine KD

Title

Yorkie: the final destination of Hippo signaling.

Journal

Trends Cell Biol 20:410-7 (2010)
DOI:10.1016/j.tcb.2010.04.005

Reference

PMID:17975546

Authors

Buttitta LA, Edgar BA

Title

How size is controlled: from Hippos to Yorkies.

Journal

Nat Cell Biol 9:1225-7 (2007)
DOI:10.1038/ncb1107-1225

Reference

PMID:21213102

Authors

Chen L, Loh PG, Song H

Title

Structural and functional insights into the TEAD-YAP complex in the Hippo signaling pathway.

Journal

Protein Cell 1:1073-83 (2010)
DOI:10.1007/s13238-010-0138-3

Reference

PMID:19733165

Authors

Oh H, Reddy BV, Irvine KD

Title

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

Journal

Dev Biol 335:188-97 (2009)
DOI:10.1016/j.ydbio.2009.08.026

Reference

PMID:18952051

Authors

Badouel C, McNeill H

Title

Apical junctions and growth control in Drosophila.

Journal

Biochim Biophys Acta 1788:755-60 (2009)
DOI:10.1016/j.bbamem.2008.08.026

Related
pathway

csol04350

TGF-beta signaling pathway

KO pathway

ko04391

LinkDB

DBGET integrated database retrieval system