KEGG   PATHWAY: ctri00010
Entry
ctri00010                   Pathway                                
Name
Glycolysis / Gluconeogenesis - Chlamydia trachomatis IU824
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
ctri00010  Glycolysis / Gluconeogenesis
ctri00010

Module
ctri_M00002  Glycolysis, core module involving three-carbon compounds [PATH:ctri00010]
ctri_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:ctri00010]
Other DBs
GO: 0006096 0006094
Organism
Chlamydia trachomatis IU824 [GN:ctri]
Gene
BN197_3811  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
BN197_2041  pfkA; pyrophosphate--fructose 6-phosphate 1-phosphotransferase [KO:K00850] [EC:2.7.1.11]
BN197_2061  pfkA_2; pyrophosphate--fructose 6-phosphate 1-phosphotransferase [KO:K00895] [EC:2.7.1.90]
BN197_2141  dhnA; fructose-bisphosphate aldolase [KO:K11645] [EC:4.1.2.13]
BN197_3291  tpiS; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
BN197_5131  gapA; glyceraldehyde 3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
BN197_7031  pgk; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
BN197_7321  pgmA; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BN197_5951  eno; enolase [KO:K01689] [EC:4.2.1.11]
BN197_3341  pykF; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
BN197_2451  pdhA; pyruvate dehydrogenase E1 component alpha subunit [KO:K00161] [EC:1.2.4.1]
BN197_2461  pdhB; pyruvate dehydrogenase E1 component beta subunit [KO:K00162] [EC:1.2.4.1]
BN197_2471  pdhC; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex [KO:K00627] [EC:2.3.1.12]
BN197_5651  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BN197_7201  pckA; phosphoenolpyruvate carboxykinase (GTP) [KO:K01596] [EC:4.1.1.32]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
ctri00020  Citrate cycle (TCA cycle)
ctri00030  Pentose phosphate pathway
ctri00500  Starch and sucrose metabolism
ctri00620  Pyruvate metabolism
ctri00640  Propanoate metabolism
KO pathway
ko00010   
LinkDB

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