KEGG PATHWAY: ddo00260

PATHWAY: ddo00260

Entry

ddo00260                    Pathway

Name

Glycine, serine and threonine metabolism - Dokdonia donghaensis

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

ddo00260

Glycine, serine and threonine metabolism

Module

ddo_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ddo00260]

ddo_M00621

Glycine cleavage system [PATH:ddo00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Dokdonia donghaensis [GN:ddo]

Gene

I597_0192

gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]

I597_0218

thrA_1; Bifunctional aspartokinase/homoserine dehydrogenase 1 [KO:K00003] [EC:1.1.1.3]

I597_0445

lysC_1; Lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]

I597_0451

ddc; L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]

I597_0456

serA_1; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

I597_0589

kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]

I597_0768

asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

I597_0999

lysC_2; Lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]

I597_1061

gcvH; Glycine cleavage system H protein [KO:K02437]

I597_1176

tdcG; L-serine dehydratase TdcG [KO:K01752] [EC:4.3.1.17]

I597_1207

gcvP; Glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]

I597_1436

trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]

I597_1438

trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]

I597_1552

[KO:K17103] [EC:2.7.8.8]

I597_1660

lpd3; Dihydrolipoyl dehydrogenase 3 [KO:K00382] [EC:1.8.1.4]

I597_1692

ltaA; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]

I597_1696

cbs_1; Putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

I597_1697

[KO:K00639] [EC:2.3.1.29]

I597_1749

cbs_2; Putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

I597_1770

gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]

I597_1772

thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]

I597_1869

glxK; Glycerate kinase [KO:K00865] [EC:2.7.1.165]

I597_1884

glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

I597_2317

serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

I597_2318

serA_2; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

I597_2326

thrA_2; Bifunctional aspartokinase/homoserine dehydrogenase 1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]

I597_2327

thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]

I597_2630

lpdC; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]

I597_2650

tdcB; L-threonine dehydratase catabolic TdcB [KO:K01754] [EC:4.3.1.19]

I597_2816

[KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

C23135

(2S,3S)-2-Acetamido-3-hydroxy-4-aminobutyrate

C23136

4-Amino-L-allothreonine

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721