KEGG   DISEASE: 多発性硬化症
エントリ  
H01490                                                             
名称    
多発性硬化症
概要    
Multiple Sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination and axonal loss. This disease typically strikes young adults, especially women. There are four types of MS according to their relapsing or progressive pattern that include relapsing-remitting (RRMS), secondary progressive (SPMS), primary progressive (PPMS), and progressive relapsing (PRMS). In most patients, the disease has a relapsing-remitting course during the first years. Within 10 years, approximately 50% of patients progress to SPMS. The aetiology of MS is not well understood, but it is likely multifactorial, combining both genetic and environmental factors. Recently, the literature on the risk factors for MS has grown substantially. They indicate that a combination of a genetic predisposition, exposure to Epstein-Barr virus, cigarette smoking, and reduced sunlight exposure/vitamin D levels is involved. Authorized first-line treatments are considered equally effective, and include interferon beta and glatiramer acetate. They are primarily directed against inflammation, and might fail to adequately control disease activity in some patients. In that case, it has been recommended to switch these patients early to a therapy of higher efficacy. Currently, 13 different drugs with ten different active components are licensed in the European Union (EU) and the United States (US) for the treatment of MS.
カテゴリ  
神経系疾患
階層分類  
ヒト疾患 [BR:jp08402]
 神経系疾患
  その他の神経系および感覚器系疾患
   H01490  多発性硬化症
ICD-11 による疾患分類 [BR:jp08403]
 08 神経系の疾患
  多発性硬化症またはその他の白質異常
   8A40  多発性硬化症
    H01490  多発性硬化症
特定疾患 (難病) [jp08407.html]
 H01490
関連パスウェイ
hsa04514  Cell adhesion molecules
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04612  Antigen processing and presentation
hsa04640  Hematopoietic cell lineage
病因遺伝子 
PDCD1 [HSA:5133] [KO:K06744]
HLA-DRB1 [HSA:3123] [KO:K06752]
HLA-DQB1 [HSA:3119] [KO:K06752]
TNFRSF1A [HSA:7132] [KO:K03158]
治療薬   
オファツムマブ [DR:D09314]
ナタリズマブ [DR:D06886]
フマル酸ジメチル [DR:D03846]
ダントロレンナトリウム水和物 [DR:D02274]
バクロフェン [DR:D00241]
チザニジン塩酸塩 [DR:D00776]
アフロクアロン [DR:D01638]
デキサメタゾン [DR:D00292]
デキサメタゾンリン酸エステルナトリウム [DR:D00975]
ベタメタゾンリン酸エステルナトリウム [DR:D00972]
トリアムシノロンアセトニド [DR:D00983]
ヒドロコルチゾン [DR:D00088]
ヒドロコルチゾンコハク酸エステルナトリウム [DR:D00978]
トリアムシノロン [DR:D00385]
ベタメタゾン [DR:D00244]
プレドニゾロン [DR:D00472]
プレドニゾロンコハク酸エステルナトリウム [DR:D01239]
メチルプレドニゾロン [DR:D00407]
メチルプレドニゾロンコハク酸エステルナトリウム [DR:D00751]
メチルプレドニゾロン酢酸エステル [DR:D00979]
グラチラマー酢酸塩 [DR:D04318]
フィンゴリモド塩酸塩 [DR:D04187]
シポニモドフマル酸 [DR:D11072]
インターフェロンベータ-1a [DR:D04554]
インターフェロンベータ-1b [DR:D00746]
リンク   
ICD-11: 8A40
ICD-10: G35
MeSH: D009103
OMIM: 126200 614810
文献    
  著者
Milo R, Miller A
  タイトル
Revised diagnostic criteria of multiple sclerosis.
  雑誌
Autoimmun Rev 13:518-24 (2014)
DOI:10.1016/j.autrev.2014.01.012
文献    
  著者
McKay KA, Kwan V, Duggan T, Tremlett H
  タイトル
Risk factors associated with the onset of relapsing-remitting and primary progressive multiple sclerosis: a systematic review.
  雑誌
Biomed Res Int 2015:817238 (2015)
DOI:10.1155/2015/817238
文献    
  著者
Goris A, Pauwels I, Dubois B
  タイトル
Progress in multiple sclerosis genetics.
  雑誌
Curr Genomics 13:646-63 (2012)
DOI:10.2174/138920212803759695
文献    
PMID:16945427 (marker)
  著者
Link H, Huang YM
  タイトル
Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness.
  雑誌
J Neuroimmunol 180:17-28 (2006)
DOI:10.1016/j.jneuroim.2006.07.006
文献    
PMID:26810535 (drug)
  著者
Rio J, Ruiz-Pena JL
  タイトル
Short-term suboptimal response criteria for predicting long-term non-response to first-line disease modifying therapies in multiple sclerosis: A systematic review and meta-analysis.
  雑誌
J Neurol Sci 361:158-67 (2016)
DOI:10.1016/j.jns.2015.12.043
文献    
PMID:25912246 (drug)
  著者
Dorr J, Paul F
  タイトル
The transition from first-line to second-line therapy in multiple sclerosis.
  雑誌
Curr Treat Options Neurol 17:354 (2015)
DOI:10.1007/s11940-015-0354-5
LinkDB    

» English version

DBGET integrated database retrieval system