KEGG   ORTHOLOGY: K03158
Entry
K03158                      KO                                     
Symbol
TNFRSF1A, TNFR1, CD120a
Name
tumor necrosis factor receptor superfamily member 1A
Pathway
map04010  MAPK signaling pathway
map04060  Cytokine-cytokine receptor interaction
map04061  Viral protein interaction with cytokine and cytokine receptor
map04064  NF-kappa B signaling pathway
map04071  Sphingolipid signaling pathway
map04150  mTOR signaling pathway
map04210  Apoptosis
map04215  Apoptosis - multiple species
map04217  Necroptosis
map04380  Osteoclast differentiation
map04668  TNF signaling pathway
map04920  Adipocytokine signaling pathway
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04936  Alcoholic liver disease
map05010  Alzheimer disease
map05014  Amyotrophic lateral sclerosis
map05022  Pathways of neurodegeneration - multiple diseases
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05142  Chagas disease
map05145  Toxoplasmosis
map05152  Tuberculosis
map05160  Hepatitis C
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H00912  Tumor necrosis factor receptor-associated periodic syndrome
H01490  Multiple sclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   04064 NF-kappa B signaling pathway
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   04668 TNF signaling pathway
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   04071 Sphingolipid signaling pathway
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   04150 mTOR signaling pathway
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   04061 Viral protein interaction with cytokine and cytokine receptor
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   04215 Apoptosis - multiple species
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   04217 Necroptosis
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
 09150 Organismal Systems
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05170 Human immunodeficiency virus 1 infection
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05160 Hepatitis C
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05171 Coronavirus disease - COVID-19
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05164 Influenza A
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05168 Herpes simplex virus 1 infection
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05163 Human cytomegalovirus infection
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05167 Kaposi sarcoma-associated herpesvirus infection
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05165 Human papillomavirus infection
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05132 Salmonella infection
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05131 Shigellosis
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05152 Tuberculosis
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05142 Chagas disease
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05014 Amyotrophic lateral sclerosis
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05022 Pathways of neurodegeneration - multiple diseases
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   05418 Fluid shear stress and atherosclerosis
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   04932 Non-alcoholic fatty liver disease
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   04931 Insulin resistance
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
   04090 CD molecules
    K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
Cytokine receptors [BR:ko04050]
 Tumor necrosis factor receptors
  TNF receptor superfamily
   K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
CD molecules [BR:ko04090]
 Proteins
  K03158  CD120a, TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
Other DBs
GO: 0005031
Genes
HSA: 7132(TNFRSF1A)
PTR: 466934(TNFRSF1A)
PPS: 100983212(TNFRSF1A)
GGO: 101149216(TNFRSF1A)
PON: 100438667(TNFRSF1A)
NLE: 100581749(TNFRSF1A)
MCC: 722033(TNFRSF1A)
MCF: 102135285(TNFRSF1A)
CSAB: 103218446(TNFRSF1A)
CATY: 105583011(TNFRSF1A)
PANU: 101013835(TNFRSF1A)
TGE: 112635096(TNFRSF1A)
RRO: 104680127(TNFRSF1A)
RBB: 108536511(TNFRSF1A)
TFN: 117090649(TNFRSF1A)
PTEH: 111555942(TNFRSF1A)
CJC: 100397418(TNFRSF1A)
SBQ: 104649955(TNFRSF1A)
CSYR: 103250566(TNFRSF1A)
MMUR: 105869061(TNFRSF1A)
OGA: 100955892(TNFRSF1A)
MMU: 21937(Tnfrsf1a)
MCAL: 110296205(Tnfrsf1a)
MPAH: 110316225(Tnfrsf1a)
RNO: 25625(Tnfrsf1a)
MCOC: 116099614(Tnfrsf1a)
MUN: 110548604(Tnfrsf1a)
CGE: 100765017(Tnfrsf1a)
PLEU: 114708799(Tnfrsf1a)
NGI: 103727530(Tnfrsf1a)
HGL: 101698980(Tnfrsf1a)
CPOC: 100713890(Tnfrsf1a)
CCAN: 109682791(Tnfrsf1a)
DORD: 105991035(Tnfrsf1a)
DSP: 122102541(Tnfrsf1a)
NCAR: 124984003
OCU: 100346106(TNFRSF1A)
OPI: 101530319(TNFRSF1A)
TUP: 102493692(TNFRSF1A)
CFA: 403634(TNFRSF1A)
VVP: 112917515(TNFRSF1A)
VLG: 121480007(TNFRSF1A)
AML: 100479926(TNFRSF1A)
UMR: 103656234(TNFRSF1A)
UAH: 113257988(TNFRSF1A)
UAR: 123781572(TNFRSF1A)
ELK: 111159748
LLV: 125107758
MPUF: 101676562(TNFRSF1A)
ORO: 101386839(TNFRSF1A)
EJU: 114222480(TNFRSF1A)
ZCA: 113922015(TNFRSF1A)
MLX: 118025746(TNFRSF1A)
FCA: 493957(TNFRSF1A)
PYU: 121021982(TNFRSF1A)
PBG: 122473857(TNFRSF1A)
PTG: 102956793(TNFRSF1A)
PPAD: 109276143(TNFRSF1A)
AJU: 106965450(TNFRSF1A)
HHV: 120221151(TNFRSF1A)
BTA: 282527(TNFRSF1A)
BOM: 102285873(TNFRSF1A)
BIU: 109559729(TNFRSF1A)
BBUB: 102398200(TNFRSF1A)
CHX: 102190310(TNFRSF1A)
OAS: 100135698(TNFRSF1A)
ODA: 120858711(TNFRSF1A)
CCAD: 122423229(TNFRSF1A)
SSC: 397020(TNFRSF1A)
CFR: 102508884(TNFRSF1A)
CBAI: 105071112(TNFRSF1A)
CDK: 105098228(TNFRSF1A)
VPC: 102544341(TNFRSF1A)
BACU: 103016474(TNFRSF1A)
LVE: 103072461(TNFRSF1A)
OOR: 101282502(TNFRSF1A)
DLE: 111176656(TNFRSF1A)
PCAD: 102980613(TNFRSF1A)
PSIU: 116760562(TNFRSF1A)
ECB: 100059548(TNFRSF1A)
EPZ: 103546993(TNFRSF1A)
EAI: 106831483(TNFRSF1A)
MYB: 102251038(TNFRSF1A)
MYD: 102768884(TNFRSF1A)
MMYO: 118649937(TNFRSF1A)
MLF: 102419664(TNFRSF1A)
MNA: 107544039(TNFRSF1A)
PKL: 118728672(TNFRSF1A)
HAI: 109373644(TNFRSF1A)
DRO: 112321955(TNFRSF1A)
SHON: 119002559(TNFRSF1A)
AJM: 119060225(TNFRSF1A)
PDIC: 114514124(TNFRSF1A)
PHAS: 123810612(TNFRSF1A)
MMF: 118623904(TNFRSF1A)
RFQ: 117028184(TNFRSF1A)
PALE: 102885752(TNFRSF1A)
PGIG: 120611633(TNFRSF1A)
PVP: 105295979(TNFRSF1A)
RAY: 107519788(TNFRSF1A)
MJV: 108387612(TNFRSF1A)
TOD: 119247799(TNFRSF1A)
SARA: 101541261(TNFRSF1A)
LAV: 100672143(TNFRSF1A)
TMU: 101341867
DNM: 101431862(TNFRSF1A)
MDO: 103104450(TNFRSF1A)
GAS: 123250637(TNFRSF1A)
SHR: 100919788(TNFRSF1A)
PCW: 110213819(TNFRSF1A)
OAA: 100085735(TNFRSF1A)
GGA: 418325(TNFRSF1A)
PCOC: 116242339(TNFRSF1A)
MGP: 100544064
CJO: 107319582(TNFRSF1A)
NMEL: 110399139
APLA: 101801004
ACYG: 106045750(TNFRSF1A)
AFUL: 116495970(TNFRSF1A)
TGU: 100227485(TNFRSF1A)
LSR: 110480833
SCAN: 103812440(TNFRSF1A)
PMOA: 120506348(TNFRSF1A)
OTC: 121339307(TNFRSF1A)
PRUF: 121351612(TNFRSF1A)
GFR: 102036131(TNFRSF1A)
FAB: 101821296(TNFRSF1A)
PHI: 102104037(TNFRSF1A)
PMAJ: 107208773(TNFRSF1A)
CCAE: 111938725(TNFRSF1A)
CCW: 104687033(TNFRSF1A)
ETL: 114062554(TNFRSF1A)
ZAB: 102065462
FPG: 101917376(TNFRSF1A)
FCH: 102057894(TNFRSF1A)
CLV: 102084092(TNFRSF1A)
EGZ: 104126570
NNI: 104008622(TNFRSF1A)
ACUN: 113480530
TALA: 104355737
PADL: 103922177
ACHC: 115343515(TNFRSF1A)
AAM: 106497278(TNFRSF1A)
AROW: 112965943(TNFRSF1A)
NPD: 112956891(TNFRSF1A)
DNE: 112985092
ASN: 102378637(TNFRSF1A)
AMJ: 102560352(TNFRSF1A)
CPOO: 109319184(TNFRSF1A)
GGN: 109304644(TNFRSF1A)
PSS: 102445357(TNFRSF1A)
CMY: 102942749(TNFRSF1A)
CPIC: 101951781
TST: 117886471(TNFRSF1A)
CABI: 116820865(TNFRSF1A)
MRV: 120400408
ACS: 100556341
PVT: 110076953
SUND: 121922349
PBI: 103049228
PMUR: 107284100
PGUT: 117661876
VKO: 123033212
ZVI: 118097922
GJA: 107121596
STOW: 125437205(TNFRSF1A)
XLA: 100137626(tnfrsf1a.S) 108696066(tnfrsf1a.L)
XTR: 100144930(tnfrsf1a)
NPR: 108795999(TNFRSF1A)
BBUF: 121003720(TNFRSF1A)
DRE: 406471(tnfrsf1a)
PPRM: 120495090(tnfrsf1a)
MAMB: 125244232(tnfrsf1a)
IPU: 108268297(tnfrsf1a) 108276487(si:ch211-112c15.8)
SMEO: 124385235(tnfrsf1a)
TFD: 113644877(tnfrsf1a) 113658075(si:ch211-112c15.8)
TRU: 101071351(tnfrsf1a) 115248670
LCO: 104929001(tnfrsf1a)
NCC: 104944949(tnfrsf1a)
CGOB: 115011263
ELY: 117258114(si:ch211-112c15.8) 117265478(tnfrsf1a)
PLEP: 121945275(tnfrsf1a)
SLUC: 116040732(si:ch211-112c15.8) 116049703(tnfrsf1a)
ECRA: 117946254(tnfrsf1a) 117947296(si:ch211-112c15.8)
PFLV: 114557503(tnfrsf1a)
GAT: 120810850(tnfrsf1a) 120828695(si:ch211-112c15.8)
PPUG: 119197254(tnfrsf1a) 119223680(si:ch211-112c15.8)
MSAM: 119897443(tnfrsf1a)
CUD: 121513451(tnfrsf1a) 121518061(si:ch211-112c15.8)
ONL: 100705695(tnfrsf1a) 102080840
OAU: 116309796(si:ch211-112c15.8) 116323788(tnfrsf1a)
OLA: 105354417 105355952(tnfrsf1a)
OML: 112143685(tnfrsf1a) 112159842(si:ch211-112c15.8)
XMA: 102237252(tnfrsf1a)
XCO: 114141624(tnfrsf1a)
XHE: 116717097(tnfrsf1a) 116725703
PRET: 103478006(tnfrsf1a)
PFOR: 103136739(tnfrsf1a) 103138949
PLAI: 106955764(tnfrsf1a) 106960027
PMEI: 106921375(tnfrsf1a) 106921698
GAF: 122831012(tnfrsf1a) 122836214(si:ch211-112c15.8)
CVG: 107082260(tnfrsf1a)
CTUL: 119782197(si:ch211-112c15.8) 119783104(tnfrsf1a)
GMU: 124862998(si:ch211-112c15.8) 124866320(tnfrsf1a)
NFU: 107379450(tnfrsf1a)
KMR: 108235424(tnfrsf1a) 108236809(si:ch211-112c15.8)
ALIM: 106529152(tnfrsf1a)
NWH: 119417295(si:ch211-112c15.8)
AOCE: 111586342
CSEM: 103387943(tnfrsf1a)
POV: 109633293(tnfrsf1a)
SSEN: 122774113(tnfrsf1a) 122777868(si:ch211-112c15.8)
HHIP: 117776812(tnfrsf1a)
LCF: 108887354(tnfrsf1a)
SDU: 111230077(tnfrsf1a)
XGL: 120784104(tnfrsf1a) 120804310(si:ch211-112c15.8)
HCQ: 109515323
BPEC: 110163065(tnfrsf1a)
MALB: 109966194(tnfrsf1a) 109972122
OGO: 123998107 124005686(tnfrsf1a) 124031884
SALP: 111976650 112071697(tnfrsf1a)
SFM: 108925658(tnfrsf1a)
PKI: 111841368
AANG: 118207705(si:ch211-112c15.8) 118220060(tnfrsf1a)
PSPA: 121325679
ARUT: 117425211(tnfrsf1a)
LCM: 102356355(TNFRSF1A)
BBEL: 109485168
CRG: 105344171
MMER: 123529209
OSN: 115224693
 » show all
Reference
PMID:2158862
  Authors
Loetscher H, Pan YC, Lahm HW, Gentz R, Brockhaus M, Tabuchi H, Lesslauer W
  Title
Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor.
  Journal
Cell 61:351-9 (1990)
DOI:10.1016/0092-8674(90)90815-V
  Sequence
[hsa:7132]
Reference
PMID:1849278
  Authors
Lewis M, Tartaglia LA, Lee A, Bennett GL, Rice GC, Wong GH, Chen EY, Goeddel DV
  Title
Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.
  Journal
Proc Natl Acad Sci U S A 88:2830-4 (1991)
DOI:10.1073/pnas.88.7.2830
  Sequence
[mmu:21937]
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