KEGG   DISEASE: 成長ホルモン単独欠損症
エントリ  
H02035                                                             
名称    
成長ホルモン単独欠損症
  上位グループ
成長ホルモン分泌不全症 [DS:H00254]
下垂体前葉機能低下症 [DS:H01700]
概要    
Isolated growth hormone deficiency (IGHD) is conditions associated with childhood growth failure due to lack of growth hormone (GH) action, and not necessarily associated with other pituitary hormone deficiencies or with an organic lesion. About 5-30% of patients are found to have affected first-degree relatives, suggesting genetic causes. IGHD has been classified into three types. IGHD type 1, characterized by autosomal recessive transmission, is further separated into subtypes 1A and 1B. The phenotype of IGHD type 1B is milder than that of IGHD type 1A. IGHD type 2 is inherited in an autosomal dominant pattern. IGHD type 3 is an X-linked recessive disorder with a highly variable phenotype. Some individuals have an associated agammaglobulinemia.
カテゴリ  
内分泌代謝疾患
階層分類  
ICD-11 による疾患分類 [BR:jp08403]
 05 内分泌, 栄養, 代謝の疾患
  内分泌疾患
   下垂体ホルモン系の疾患
    5A61  下垂体機能低下症またはその他の明示された下垂体の疾患
     H02035  成長ホルモン単独欠損症
パスウェイに基づく疾患分類 [BR:jp08402]
 シグナル伝達
  nt06518  JAK-STAT シグナリング
   H02035  成長ホルモン単独欠損症
 内分泌系
  nt06324  GHRH-GH-IGF シグナリング
   H02035  成長ホルモン単独欠損症
パスウェイ 
hsa04630  JAK-STAT signaling pathway
ネットワーク
nt06324 GHRH-GH-IGF signaling
nt06518 JAK-STAT signaling
病因遺伝子 
(IGHD1A/1B/2) GH1 [HSA:2688] [KO:K05438]
(IGHD3) BTK [HSA:695] [KO:K07370]
(IGHD4) GHRHR [HSA:2692] [KO:K04584]
(IGHD5) RNPC3 [HSA:55599] [KO:K13157]
治療薬   
メカセルミン [DR:D03297]
リンク   
ICD-11: 5A61.0
MeSH: C537404 C567564 C562704 C537149
OMIM: 262400 612781 173100 307200 618157 618160
文献    
  著者
Hernandez LM, Lee PD, Camacho-Hubner C
  タイトル
Isolated growth hormone deficiency.
  雑誌
Pituitary 10:351-7 (2007)
DOI:10.1007/s11102-007-0073-3
文献    
  著者
Hess O, Hujeirat Y, Wajnrajch MP, Allon-Shalev S, Zadik Z, Lavi I, Tenenbaum-Rakover Y
  タイトル
Variable phenotypes in familial isolated growth hormone deficiency caused by a G6664A mutation in the GH-1 gene.
  雑誌
J Clin Endocrinol Metab 92:4387-93 (2007)
DOI:10.1210/jc.2007-0684
文献    
PMID:8496314 (IGHD1A/1B)
  著者
Cogan JD, Phillips JA 3rd, Sakati N, Frisch H, Schober E, Milner RD
  タイトル
Heterogeneous growth hormone (GH) gene mutations in familial GH deficiency.
  雑誌
J Clin Endocrinol Metab 76:1224-8 (1993)
DOI:10.1210/jcem.76.5.8496314
文献    
PMID:8288694 (IGHD2)
  著者
Phillips JA 3rd, Cogan JD
  タイトル
Genetic basis of endocrine disease. 6. Molecular basis of familial human growth hormone deficiency.
  雑誌
J Clin Endocrinol Metab 78:11-6 (1994)
DOI:10.1210/jcem.78.1.8288694
文献    
PMID:8013627 (IGHD3)
  著者
Duriez B, Duquesnoy P, Dastot F, Bougneres P, Amselem S, Goossens M
  タイトル
An exon-skipping mutation in the btk gene of a patient with X-linked agammaglobulinemia and isolated growth hormone deficiency.
  雑誌
FEBS Lett 346:165-70 (1994)
DOI:10.1016/0014-5793(94)00457-9
文献    
PMID:8528260 (IGHD4)
  著者
Wajnrajch MP, Gertner JM, Harbison MD, Chua SC Jr, Leibel RL
  タイトル
Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse.
  雑誌
Nat Genet 12:88-90 (1996)
DOI:10.1038/ng0196-88
文献    
PMID:24480542 (IGHD5)
  著者
Argente J, Flores R, Gutierrez-Arumi A, Verma B, Martos-Moreno GA, Cusco I, Oghabian A, Chowen JA, Frilander MJ, Perez-Jurado LA
  タイトル
Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency.
  雑誌
EMBO Mol Med 6:299-306 (2014)
DOI:10.1002/emmm.201303573
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