KEGG   PATHWAY: ebs00260
Entry
ebs00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Ectothiorhodospira sp. BSL-9
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ebs00260  Glycine, serine and threonine metabolism
ebs00260

Module
ebs_M00555  Betaine biosynthesis, choline => betaine [PATH:ebs00260]
ebs_M00621  Glycine cleavage system [PATH:ebs00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Ectothiorhodospira sp. BSL-9 [GN:ebs]
Gene
ECTOBSL9_2498  aspartate kinase [KO:K00928] [EC:2.7.2.4]
ECTOBSL9_2069  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
ECTOBSL9_2646  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
ECTOBSL9_2647  L-threonine synthase [KO:K01733] [EC:4.2.3.1]
ECTOBSL9_0051  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ECTOBSL9_0064  alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
ECTOBSL9_2169  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
ECTOBSL9_1943  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
ECTOBSL9_0813  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
ECTOBSL9_2961  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ECTOBSL9_2962  MFS transporter [KO:K00831] [EC:2.6.1.52]
ECTOBSL9_1866  glycine dehydrogenase [KO:K00282] [EC:1.4.4.2]
ECTOBSL9_1868  glycine dehydrogenase [KO:K00283] [EC:1.4.4.2]
ECTOBSL9_1864  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
ECTOBSL9_0782  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ECTOBSL9_1801  pyridine nucleotide-disulfide oxidoreductase [KO:K00382] [EC:1.8.1.4]
ECTOBSL9_1121  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ECTOBSL9_2155  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ECTOBSL9_1865  glycine cleavage system protein H [KO:K02437]
ECTOBSL9_0281  glycine cleavage system protein H [KO:K02437]
ECTOBSL9_0279  glycine cleavage system protein H [KO:K02437]
ECTOBSL9_0204  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
ECTOBSL9_2012  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
ECTOBSL9_0668  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
ECTOBSL9_0667  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
ECTOBSL9_2257  methyltransferase type 11 [KO:K18896] [EC:2.1.1.156]
ECTOBSL9_2476  SAM-dependent methyltransferase [KO:K18896] [EC:2.1.1.156]
ECTOBSL9_2475  methyltransferase [KO:K18897] [EC:2.1.1.157]
ECTOBSL9_1852  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
ECTOBSL9_2075  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
ECTOBSL9_2074  tryptophan synthase subunit alpha [KO:K01696] [EC:4.2.1.20]
ECTOBSL9_2459  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ebs00010  Glycolysis / Gluconeogenesis
ebs00020  Citrate cycle (TCA cycle)
ebs00230  Purine metabolism
ebs00250  Alanine, aspartate and glutamate metabolism
ebs00270  Cysteine and methionine metabolism
ebs00290  Valine, leucine and isoleucine biosynthesis
ebs00300  Lysine biosynthesis
ebs00330  Arginine and proline metabolism
ebs00460  Cyanoamino acid metabolism
ebs00470  D-Amino acid metabolism
ebs00564  Glycerophospholipid metabolism
ebs00620  Pyruvate metabolism
ebs00630  Glyoxylate and dicarboxylate metabolism
ebs00640  Propanoate metabolism
ebs00680  Methane metabolism
ebs00860  Porphyrin metabolism
ebs00920  Sulfur metabolism
KO pathway
ko00260   
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