KEGG   PATHWAY: ecoh00790
Entry
ecoh00790                   Pathway                                
Name
Folate biosynthesis - Escherichia coli O145:H28 RM13516 (EHEC)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
ecoh00790  Folate biosynthesis
ecoh00790

Module
ecoh_M00880  Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:ecoh00790]
Other DBs
GO: 0046656
Organism
Escherichia coli O145:H28 RM13516 (EHEC) [GN:ecoh]
Gene
ECRM13516_0008  mogA; Molybdopterin biosynthesis Mog protein, molybdochelatase [KO:K03831] [EC:2.7.7.75]
ECRM13516_0051  folA; Dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
ECRM13516_0150  folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [KO:K00950] [EC:2.7.6.3]
ECRM13516_0361  phoA; Alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
ECRM13516_0428  ybaX; Queuosine Biosynthesis QueC ATPase [KO:K06920] [EC:6.3.4.20]
ECRM13516_0811  moaA; Molybdenum cofactor biosynthesis protein MoaA [KO:K03639] [EC:4.1.99.22]
ECRM13516_0812  moaB; Molybdenum cofactor biosynthesis protein MoaB [KO:K03638] [EC:2.7.7.75]
ECRM13516_0813  [KO:K03637] [EC:4.6.1.17]
ECRM13516_0815  moaE; Molybdenum cofactor biosynthesis protein MoaE [KO:K03635] [EC:2.8.1.12]
ECRM13516_0859  moeA; Molybdopterin biosynthesis protein MoeA [KO:K03750] [EC:2.10.1.1]
ECRM13516_1345  pabC; Aminodeoxychorismate lyase [KO:K02619] [EC:4.1.3.38]
ECRM13516_1663  ribA; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
ECRM13516_2000  ydgB; FolM Alternative dihydrofolate reductase 1 [KO:K13938] [EC:1.5.1.50 1.5.1.3]
ECRM13516_2219  pabB; Para-aminobenzoate synthase, aminase component [KO:K01665] [EC:2.6.1.85]
ECRM13516_2277  ntpA; Dihydroneopterin triphosphate pyrophosphohydrolase type 2 (nudB) [KO:K08310] [EC:3.6.1.67]
ECRM13516_3004  folX; Dihydroneopterin triphosphate epimerase [KO:K07589] [EC:5.1.99.7]
ECRM13516_3016  folC; Dihydrofolate synthase / Folylpolyglutamate synthase [KO:K11754] [EC:6.3.2.12 6.3.2.17]
ECRM13516_3487  ygcM; Queuosine biosynthesis QueD, PTPS-I [KO:K01737] [EC:4.2.3.12 4.1.2.50]
ECRM13516_3498  ygcF; Queuosine Biosynthesis QueE Radical SAM [KO:K10026] [EC:4.3.99.3]
ECRM13516_3521  queF; NADPH-dependent 7-cyano-7-deazaguanine reductase [KO:K06879] [EC:1.7.1.13]
ECRM13516_3596  ygfJ; CTP:molybdopterin cytidylyltransferase [KO:K07141] [EC:2.7.7.76]
ECRM13516_3821  folB; Dihydroneopterin aldolase [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]
ECRM13516_3940  folP; Dihydropteroate synthase [KO:K00796] [EC:2.5.1.15]
ECRM13516_4104  pabA; Para-aminobenzoate synthase, amidotransferase component [KO:K01664] [EC:2.6.1.85]
ECRM13516_4707  mobA; Molybdopterin-guanine dinucleotide biosynthesis protein MobA [KO:K03752] [EC:2.7.7.77]
ECRM13516_5069  [KO:K01737] [EC:4.2.3.12 4.1.2.50]
Compound
C00044  GTP
C00101  Tetrahydrofolate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00156  4-Hydroxybenzoate
C00251  Chorismate
C00266  Glycolaldehyde
C00268  Dihydrobiopterin
C00272  Tetrahydrobiopterin
C00415  Dihydrofolate
C00504  Folate
C00568  4-Aminobenzoate
C00835  Sepiapterin
C00921  Dihydropteroate
C01217  5,6,7,8-Tetrahydromethanopterin
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  Pyrimidodiazepine
C02953  7,8-Dihydrobiopterin
C03541  THF-polyglutamate
C03684  6-Pyruvoyltetrahydropterin
C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  7,8-Dihydroneopterin
C04895  7,8-Dihydroneopterin 3'-triphosphate
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C05924  Molybdopterin
C05925  Dihydroneopterin phosphate
C05926  Neopterin
C05927  7,8-Dihydromethanopterin
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06313  Biopterin
C09332  THF-L-glutamate
C11355  4-Amino-4-deoxychorismate
C15522  4a-Hydroxytetrahydrobiopterin
C15996  7-Cyano-7-carbaguanine
C16675  7-Aminomethyl-7-carbaguanine
C18237  Molybdoenzyme molybdenum cofactor
C18239  Precursor Z
C18802  Tetrahydrosarcinapterin
C19848  Adenylated molybdopterin
C19871  Guanylyl molybdenum cofactor
C20239  6-Carboxy-5,6,7,8-tetrahydropterin
C20248  7-Carboxy-7-carbaguanine
C20264  L-threo-Tetrahydrobiopterin
C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  7,8-Dihydroneopterin 2'-phosphate
C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  5,6,7,8-Tetrahydromonapterin
C21008  7,8-Dihydromonapterin
C21065  7,8-Dihydroxanthopterin
C21094  7,8-Dihydromonapterin 3'-triphosphate
C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  Cytidylyl molybdenum cofactor
C21486  Thio-molybdenum cofactor
C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19675644
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
PMID:16632608
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
PMID:18092812
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
PMID:12571226
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
PMID:21867484
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
PMID:12893295
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
Related
pathway
ecoh00230  Purine metabolism
ecoh00362  Benzoate degradation
ecoh00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ecoh00670  One carbon pool by folate
ecoh00680  Methane metabolism
KO pathway
ko00790   

DBGET integrated database retrieval system