KEGG   PATHWAY: ecoh00230
Entry
ecoh00230                   Pathway                                
Name
Purine metabolism - Escherichia coli O145:H28 RM13516 (EHEC)
Class
Metabolism; Nucleotide metabolism
Pathway map
ecoh00230  Purine metabolism
ecoh00230

Module
ecoh_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ecoh00230]
ecoh_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ecoh00230]
ecoh_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ecoh00230]
ecoh_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ecoh00230]
ecoh_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ecoh00230]
ecoh_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ecoh00230]
ecoh_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ecoh00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli O145:H28 RM13516 (EHEC) [GN:ecoh]
Gene
ECRM13516_3803  nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
ECRM13516_4137  nudE; ADP compounds hydrolase NudE [KO:K08312] [EC:3.6.1.-]
ECRM13516_4120  Phosphopentomutase-like protein [KO:K01839] [EC:5.4.2.7]
ECRM13516_5418  deoB; Phosphopentomutase [KO:K01839] [EC:5.4.2.7]
ECRM13516_0658  pgm; Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
ECRM13516_1534  prsA; Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
ECRM13516_3013  purF; Amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
ECRM13516_4863  purD; Phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
ECRM13516_3181  purN; Phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
ECRM13516_2260  purT; Phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
ECRM13516_3240  purL; Phosphoribosylformylglycinamidine synthase, synthetase subunit / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit [KO:K01952] [EC:6.3.5.3]
ECRM13516_3180  purM; Phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
ECRM13516_0510  purK; Phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
ECRM13516_0511  purE; Phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
ECRM13516_3155  purC; Phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
ECRM13516_1461  purB; Adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
ECRM13516_4864  purH; IMP cyclohydrolase / Phosphoribosylaminoimidazolecarboxamide formyltransferase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
ECRM13516_0453  apt; Adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
ECRM13516_0464  ushA; UDP-sugar hydrolase; 5'-nucleotidase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
ECRM13516_3461  surE; 5-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
ECRM13516_0642  nagD; Phosphatase NagD predicted to act in N-acetylglucosamine utilization subsystem [KO:K02566] [EC:3.1.3.5]
ECRM13516_4139  yrfG; putative hydrolase [KO:K20881] [EC:3.1.3.-]
ECRM13516_0461  gsk; Inosine-guanosine kinase [KO:K00892] [EC:2.7.1.73]
ECRM13516_5419  deoD; Purine nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
ECRM13516_0369  yaiE; Cytoplasmic protein YaiE [KO:K09913] [EC:2.4.2.1 2.4.2.2]
ECRM13516_3277  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
ECRM13516_0131  hpt; Hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
ECRM13516_3191  guaB; Inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
ECRM13516_3204  ndk; Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
ECRM13516_5434  yjjX; Inosine/xanthosine triphosphatase [KO:K01529] [EC:3.6.1.73]
ECRM13516_3683  yggV; Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) [KO:K01519] [EC:3.6.1.66]
ECRM13516_0247  gpt; Xanthine-guanine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
ECRM13516_3585  Xanthine dehydrogenase, molybdenum binding subunit [KO:K00087] [EC:1.17.1.4]
ECRM13516_3586  ygeT; Xanthine dehydrogenase, FAD binding subunit [KO:K13479] [EC:1.17.1.4]
ECRM13516_3587  Xanthine dehydrogenase iron-sulfur subunit [KO:K13480]
ECRM13516_0262  yagR; Periplasmic aromatic aldehyde oxidoreductase, molybdenum binding subunit YagR [KO:K11177] [EC:1.17.1.4]
ECRM13516_0263  yagS; Periplasmic aromatic aldehyde oxidoreductase, FAD binding subunit YagS [KO:K11178] [EC:1.17.1.4]
ECRM13516_0264  yagT; Periplasmic aromatic aldehyde oxidoreductase, iron-sulfur subunit YagT [KO:K13483]
ECRM13516_3190  guaA; GMP synthase [glutamine-hydrolyzing], amidotransferase subunit / GMP synthase [glutamine-hydrolyzing], ATP pyrophosphatase subunit [KO:K01951] [EC:6.3.5.2]
ECRM13516_0110  guaC; GMP reductase [KO:K00364] [EC:1.7.1.7]
ECRM13516_3602  ygfP; Guanine deaminase [KO:K01487] [EC:3.5.4.3]
ECRM13516_4437  gmk; Guanylate kinase [KO:K00942] [EC:2.7.4.8]
ECRM13516_2932  nrdA; Ribonucleotide reductase of class Ia (aerobic), alpha subunit [KO:K00525] [EC:1.17.4.1]
ECRM13516_3381  nrdE; Ribonucleotide reductase of class Ib (aerobic), alpha subunit [KO:K00525] [EC:1.17.4.1]
ECRM13516_2933  nrdB; Ribonucleotide reductase of class Ia (aerobic), beta subunit [KO:K00526] [EC:1.17.4.1]
ECRM13516_3382  nrdF; Ribonucleotide reductase of class Ib (aerobic), beta subunit [KO:K00526] [EC:1.17.4.1]
ECRM13516_5110  nrdD; Ribonucleotide reductase of class III (anaerobic), large subunit [KO:K21636] [EC:1.1.98.6]
ECRM13516_0170  dgt; Deoxyguanosinetriphosphate triphosphohydrolase, subgroup 1 [KO:K01129] [EC:3.1.5.1]
ECRM13516_2991  yfbR; Nucleotidase YfbR, HD superfamily [KO:K08722] [EC:3.1.3.89]
ECRM13516_2820  Hypothetical protein yfdR [KO:K06952] [EC:3.1.3.89]
ECRM13516_5353  Hypothetical protein [KO:K06952] [EC:3.1.3.89]
ECRM13516_4439  spoT; GTP pyrophosphokinase, (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
ECRM13516_3183  ppx; Exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ECRM13516_4623  gppA; Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ECRM13516_3508  relA; Guanosine polyphosphate pyrophosphohydrolase/synthetase [KO:K00951] [EC:2.7.6.5]
ECRM13516_4653  cyaA; Adenylate cyclase [KO:K05851] [EC:4.6.1.1]
ECRM13516_5170  purA; Adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
ECRM13516_2017  add; Adenosine deaminase [KO:K01488] [EC:3.5.4.4]
ECRM13516_2541  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
ECRM13516_3522  ygdH; Decarboxylase family protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
ECRM13516_4515  yicP; Adenine deaminase [KO:K01486] [EC:3.5.4.2]
ECRM13516_5133  cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
ECRM13516_0458  adk; Adenylate kinase [KO:K00939] [EC:2.7.4.3]
ECRM13516_3505  mazG; Nucleoside triphosphate pyrophosphohydrolase MazG [KO:K04765] [EC:3.6.1.9]
ECRM13516_3801  icc; 3',5'-cyclic-nucleotide phosphodiesterase [KO:K03651] [EC:3.1.4.53]
ECRM13516_0054  apaH; Bis(5'-nucleosyl)-tetraphosphatase, symmetrical [KO:K01525] [EC:3.6.1.41]
ECRM13516_3468  cysC; Adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
ECRM13516_3469  cysN; Sulfate adenylyltransferase subunit 1 [KO:K00956] [EC:2.7.7.4]
ECRM13516_3470  cysD; Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
ECRM13516_2452  Transthyretin family protein [KO:K07127] [EC:3.5.2.17]
ECRM13516_0500  Allantoinase [KO:K01466] [EC:3.5.2.5]
ECRM13516_0505  ylbB; Allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
ECRM13516_0504  ylbA; Ureidoglycine aminohydrolase [KO:K14977] [EC:3.5.3.26]
ECRM13516_0494  ybbT; Ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
ECRM13516_1182  ureC; Urease alpha subunit [KO:K01428] [EC:3.5.1.5]
ECRM13516_1181  ureB; Urease beta subunit [KO:K01429] [EC:3.5.1.5]
ECRM13516_1180  ureA; Urease gamma subunit [KO:K01430] [EC:3.5.1.5]
ECRM13516_0506  ylbC; Ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
ECRM13516_3593  yqeA; Carbamate kinase-like protein YqeA [KO:K00926] [EC:2.7.2.2]
ECRM13516_0300  yahI; Carbamate kinase [KO:K00926] [EC:2.7.2.2]
ECRM13516_0509  arcC; Carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ecoh00030  Pentose phosphate pathway
ecoh00220  Arginine biosynthesis
ecoh00250  Alanine, aspartate and glutamate metabolism
ecoh00260  Glycine, serine and threonine metabolism
ecoh00340  Histidine metabolism
ecoh00630  Glyoxylate and dicarboxylate metabolism
ecoh00730  Thiamine metabolism
ecoh00740  Riboflavin metabolism
ecoh00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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