| Entry |  | 
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| Name | Glutathione metabolism - Herminiimonas arsenicoxydans | 
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| Class | Metabolism; Metabolism of other amino acids
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| Pathway map |  
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| Module |  | 
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| Other DBs |  | 
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| Organism | Herminiimonas arsenicoxydans [GN:har ]
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| Gene | | HEAR0146 | gshB1; glutathione synthetase (Glutathione synthase) (GSH synthetase) (GSH-S) (GSHase) [KO:K01920] [EC:6.3.2.3] | 
 | HEAR1064 | gshA2; gamma-glutamate-cysteine ligase (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS) [KO:K01919] [EC:6.3.2.2] | 
 | HEAR2401 | pepA; Cytosol aminopeptidase (Leucine aminopeptidase) (LAP) (Leucyl aminopeptidase) [KO:K01255] [EC:3.4.11.1] | 
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| Compound | | C00669 | gamma-L-Glutamyl-L-cysteine | 
 | C03170 | Trypanothione disulfide | 
 | C03646 | Bis-gamma-glutamylcystine | 
 | C03740 | (5-L-Glutamyl)-L-amino acid | 
 | C05726 | S-Substituted L-cysteine | 
 | C05727 | S-Substituted N-acetyl-L-cysteine | 
 | C16563 | Bis(glutathionyl)spermine | 
 | C16564 | Bis(glutathionyl)spermine disulfide | 
 | C16566 | Glutathionylaminopropylcadaverine | 
 | C16568 | Homotrypanothione disulfide | 
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| Reference |  | 
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| Authors | Josch C, Klotz LO, Sies H. | 
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| Title | Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D. | 
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| Title | A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U. | 
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| Title | New role for leucyl aminopeptidase in glutathione turnover. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Suzuki H, Kamatani S, Kim ES, Kumagai H. | 
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| Title | Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Oza SL, Shaw MP, Wyllie S, Fairlamb AH. | 
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| Title | Trypanothione biosynthesis in Leishmania major. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Oza SL, Ariyanayagam MR, Fairlamb AH. | 
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| Title | Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH. | 
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| Title | Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH. | 
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| Title | Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH. | 
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| Title | Properties of trypanothione synthetase from Trypanosoma brucei. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH. | 
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| Title | A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Comini M, Menge U, Wissing J, Flohe L. | 
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| Title | Trypanothione synthesis in crithidia revisited. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Hunter KJ, Le Quesne SA, Fairlamb AH. | 
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| Title | Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Krauth-Siegel RL, Meiering SK, Schmidt H. | 
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| Title | The parasite-specific trypanothione metabolism of trypanosoma and leishmania. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Krauth-Siegel RL, Comini MA. | 
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| Title | Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Krauth-Siegel RL, Ludemann H. | 
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| Title | Reduction of dehydroascorbate by trypanothione. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL. | 
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| Title | Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Schmidt H, Krauth-Siegel RL. | 
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| Title | Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei. | 
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| Reference |  | 
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| Authors | Tetaud E, Fairlamb AH. | 
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| Title | Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata. | 
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| Reference |  | 
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| Authors | Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM. | 
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| Title | Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum. | 
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| Reference |  | 
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| Authors | Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM. | 
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| Title | Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Konig J, Fairlamb AH. | 
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| Title | A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Hillebrand H, Schmidt A, Krauth-Siegel RL. | 
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| Title | A second class of peroxidases linked to the trypanothione metabolism. | 
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| Reference |  | 
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| Authors | Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K. | 
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| Title | Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli. | 
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| Journal |  | 
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| Reference |  | 
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| Authors | Pegg AE, Shuttleworth K, Hibasami H. | 
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| Title | Specificity of mammalian spermidine synthase and spermine synthase. | 
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| Related pathway
 | | har00250 | Alanine, aspartate and glutamate metabolism | 
 | har00270 | Cysteine and methionine metabolism | 
 | har00430 | Taurine and hypotaurine metabolism | 
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| KO pathway |  | 
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