KEGG   PATHWAY: hmh04975
Entry
hmh04975                    Pathway                                
Name
Fat digestion and absorption - Hylobates moloch (silvery gibbon)
Description
Fat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, dietary TAG is hydrolyzed to fatty acids (FA) and monoacylglycerols (MAG) by pancreatic lipase. These products are then emulsified with the help of phospholipids (PL) and bile acids (BA) present in bile to form micelles. Free FAs and MAGs are taken up by the enterocyte where they are rapidly resynthesized in endoplasmic reticulum (ER) to form TAG. PLs from the diet as well as bile - mainly LPA - too are absorbed by the enterocyte and are acylated to form phosphatidic acid (PA), which is also converted into TAG. Absorbed cholesterol (CL) is acylated to cholesterol esters (CE). Within the ER, TAG joins CE and apolipoprotein B (ApoB) to form chylomicrons that enter circulation through the lymph.
Class
Organismal Systems; Digestive system
Pathway map
hmh04975  Fat digestion and absorption
hmh04975

Other DBs
GO: 0044241 0030299
Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116457880  LIPF; gastric triacylglycerol lipase isoform X2 [KO:K14452] [EC:3.1.1.3]
116458113  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
116459014  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
116459267  [KO:K01047] [EC:3.1.1.4]
116459658  CLPS; colipase isoform X1 [KO:K14460]
116460314  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
116462689  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
116462701  PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
116463430  FABP2; fatty acid-binding protein, intestinal [KO:K08751]
116463683  [KO:K01047] [EC:3.1.1.4]
116463687  [KO:K01047] [EC:3.1.1.4]
116471334  GOT2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
116473552  ACAT2; acetyl-CoA acetyltransferase, cytosolic isoform X1 [KO:K00626] [EC:2.3.1.9]
116474868  MTTP; microsomal triglyceride transfer protein large subunit isoform X1 [KO:K14463]
116475500  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
116475717  SLC27A4; long-chain fatty acid transport protein 4 isoform X1 [KO:K08745] [EC:6.2.1.-]
116475807  CEL; bile salt-activated lipase [KO:K12298] [EC:3.1.1.3 3.1.1.13]
116475882  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
116476704  DGAT2; diacylglycerol O-acyltransferase 2 isoform X2 [KO:K11160] [EC:2.3.1.20 2.3.1.75]
116476896  ACAT1; acetyl-CoA acetyltransferase, mitochondrial isoform X2 [KO:K00626] [EC:2.3.1.9]
116476973  APOA4; apolipoprotein A-IV [KO:K08760]
116476975  APOA1; apolipoprotein A-I [KO:K08757]
116477383  MOGAT2; 2-acylglycerol O-acyltransferase 2 [KO:K14457] [EC:2.3.1.22]
116477710  SCARB1; scavenger receptor class B member 1 isoform X4 [KO:K13885]
116478472  [KO:K14075] [EC:3.1.1.3]
116478481  [KO:K14074] [EC:3.1.1.3]
116478672  SLC27A1; long-chain fatty acid transport protein 1 isoform X1 [KO:K08745] [EC:6.2.1.-]
116479390  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
116480381  APOB; apolipoprotein B-100 [KO:K14462]
116483124  [KO:K14073] [EC:3.1.1.3]
116483396  FABP1; fatty acid-binding protein, liver [KO:K08750]
116483745  ABCG5; ATP-binding cassette sub-family G member 5 [KO:K05683]
116484267  ABCG8; ATP-binding cassette sub-family G member 8 [KO:K05684]
116810970  MOGAT3; 2-acylglycerol O-acyltransferase 3 [KO:K14456] [EC:2.3.1.20 2.3.1.22]
116811248  [KO:K14457] [EC:2.3.1.22]
116812485  NPC1L1; NPC1-like intracellular cholesterol transporter 1 [KO:K14461]
116812648  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
116813022  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
116813023  PLA2G5; phospholipase A2 group V isoform X2 [KO:K01047] [EC:3.1.1.4]
116813701  DGAT1; diacylglycerol O-acyltransferase 1 isoform X1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
116813919  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
116813921  PLA2G2D; group IID secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
116813922  PLA2G2C; LOW QUALITY PROTEIN: putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
116814164  CD36; platelet glycoprotein 4 [KO:K06259]
Compound
C00010  CoA
C00040  Acyl-CoA
C00162  Fatty acid
C00165  Diacylglycerol
C00187  Cholesterol
C00416  Phosphatidate
C00422  Triacylglycerol
C00681  1-Acyl-sn-glycerol 3-phosphate
C00865  Phospholipid
C01558  Bile salt
C01885  1-Acylglycerol
C02112  2-Acylglycerol
C02530  Cholesterol ester
Reference
PMID:19158321
  Authors
Iqbal J, Hussain MM
  Title
Intestinal lipid absorption.
  Journal
Am J Physiol Endocrinol Metab 296:E1183-94 (2009)
DOI:10.1152/ajpendo.90899.2008
Reference
PMID:20522896
  Authors
Goodman BE
  Title
Insights into digestion and absorption of major nutrients in humans.
  Journal
Adv Physiol Educ 34:44-53 (2010)
DOI:10.1152/advan.00094.2009
Reference
PMID:19280719
  Authors
Niot I, Poirier H, Tran TT, Besnard P
  Title
Intestinal absorption of long-chain fatty acids: evidence and uncertainties.
  Journal
Prog Lipid Res 48:101-15 (2009)
DOI:10.1016/j.plipres.2009.01.001
Reference
PMID:15286736
  Authors
Shi Y, Burn P
  Title
Lipid metabolic enzymes: emerging drug targets for the treatment of obesity.
  Journal
Nat Rev Drug Discov 3:695-710 (2004)
DOI:10.1038/nrd1469
Reference
PMID:20148678
  Authors
Mansbach CM, Siddiqi SA
  Title
The biogenesis of chylomicrons.
  Journal
Annu Rev Physiol 72:315-33 (2010)
DOI:10.1146/annurev-physiol-021909-135801
Reference
PMID:19116371
  Authors
Shi Y, Cheng D
  Title
Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism.
  Journal
Am J Physiol Endocrinol Metab 297:E10-8 (2009)
DOI:10.1152/ajpendo.90949.2008
Reference
PMID:10924713
  Authors
Ros E
  Title
Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk.
  Journal
Atherosclerosis 151:357-79 (2000)
DOI:10.1016/S0021-9150(00)00456-1
Reference
PMID:12621063
  Authors
Yen CL, Farese RV Jr
  Title
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine.
  Journal
J Biol Chem 278:18532-7 (2003)
DOI:10.1074/jbc.M301633200
Reference
PMID:17495606
  Authors
Levy E, Spahis S, Sinnett D, Peretti N, Maupas-Schwalm F, Delvin E, Lambert M, Lavoie MA
  Title
Intestinal cholesterol transport proteins: an update and beyond.
  Journal
Curr Opin Lipidol 18:310-8 (2007)
DOI:10.1097/MOL.0b013e32813fa2e2
Reference
PMID:18830418
  Authors
Williams KJ
  Title
Molecular processes that handle -- and mishandle -- dietary lipids.
  Journal
J Clin Invest 118:3247-59 (2008)
DOI:10.1172/JCI35206
Reference
PMID:11504671
  Authors
Lu K, Lee MH, Patel SB
  Title
Dietary cholesterol absorption; more than just bile.
  Journal
Trends Endocrinol Metab 12:314-20 (2001)
DOI:10.1016/S1043-2760(01)00433-7
Reference
PMID:14976303
  Authors
Klett EL, Patel SB
  Title
Biomedicine. Will the real cholesterol transporter please stand up.
  Journal
Science 303:1149-50 (2004)
DOI:10.1126/science.1095519
Reference
PMID:17002594
  Authors
Wang DQ
  Title
Regulation of intestinal cholesterol absorption.
  Journal
Annu Rev Physiol 69:221-48 (2007)
DOI:10.1146/annurev.physiol.69.031905.160725
Reference
PMID:19663632
  Authors
Patel JP, Brocks DR
  Title
The effect of oral lipids and circulating lipoproteins on the metabolism of drugs.
  Journal
Expert Opin Drug Metab Toxicol 5:1385-98 (2009)
DOI:10.1517/17425250903176439
Reference
PMID:15891388
  Authors
Hussain MM, Fatma S, Pan X, Iqbal J
  Title
Intestinal lipoprotein assembly.
  Journal
Curr Opin Lipidol 16:281-5 (2005)
DOI:10.1097/01.mol.0000169347.53568.5a
Reference
PMID:20493784
  Authors
Kindel T, Lee DM, Tso P
  Title
The mechanism of the formation and secretion of chylomicrons.
  Journal
Atheroscler Suppl 11:11-6 (2010)
DOI:10.1016/j.atherosclerosissup.2010.03.003
Related
pathway
hmh00561  Glycerolipid metabolism
hmh04530  Tight junction
hmh04972  Pancreatic secretion
hmh04976  Bile secretion
KO pathway
ko04975   

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