KEGG   PATHWAY: hmh04530
Entry
hmh04530                    Pathway                                
Name
Tight junction - Hylobates moloch (silvery gibbon)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
hmh04530  Tight junction
hmh04530

Other DBs
GO: 0005923
Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116456158  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
116456560  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
116456980  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
116457293  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
116457363  JUN; transcription factor Jun [KO:K04448]
116458085  PATJ; inaD-like protein isoform X1 [KO:K06092]
116458112  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
116458302  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
116458418  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
116458770  MYH9; myosin-9 isoform X1 [KO:K10352]
116458974  MYH10; myosin-10 isoform X1 [KO:K10352]
116459016  NF2; merlin isoform X1 [KO:K16684]
116459291  [KO:K07374]
116459306  CLDN5; claudin-5 [KO:K06087]
116459321  CLDN7; claudin-7 isoform X1 [KO:K06087]
116459981  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
116460758  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
116460769  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116461023  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116461132  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
116461198  PCNA; proliferating cell nuclear antigen [KO:K04802]
116461664  TUBA1A; tubulin alpha-1A chain [KO:K07374]
116461665  [KO:K07374]
116461669  [KO:K07374]
116461671  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
116461690  CLDN18; claudin-18 isoform X2 [KO:K06087]
116461729  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
116461750  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
116461752  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
116461858  ITGB1; integrin beta-1 [KO:K05719]
116462147  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
116462242  CLDN6; claudin-6 [KO:K06087]
116462243  CLDN9; claudin-9 [KO:K06087]
116462248  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
116462594  [KO:K06087]
116462604  MYH11; myosin-11 isoform X1 [KO:K10352]
116462606  OCLN; occludin isoform X1 [KO:K06088]
116462722  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
116462964  [KO:K07374]
116462994  ACTR3; actin-related protein 3 [KO:K18584]
116463128  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116463713  [KO:K06087]
116463728  [KO:K06087]
116464137  [KO:K06087]
116464140  [KO:K06087]
116464174  [KO:K10352]
116464194  [KO:K10352]
116464951  [KO:K05756]
116465643  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
116466053  CLDN22; claudin-22 [KO:K06087]
116466056  [KO:K06087]
116466631  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2 [KO:K05631]
116466724  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
116466880  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
116467188  [KO:K07374]
116467388  CLDN10; claudin-10 isoform X1 [KO:K06087]
116467914  CD1A; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1a [KO:K06448]
116467924  [KO:K06102]
116468021  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
116468440  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
116468516  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
116468684  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
116468710  [KO:K12757]
116468711  [KO:K12757]
116468915  [KO:K07374]
116469117  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
116469123  CTTN; src substrate cortactin isoform X1 [KO:K06106]
116469246  CD1E; T-cell surface glycoprotein CD1e, membrane-associated isoform X1 [KO:K06448]
116469247  CD1B; T-cell surface glycoprotein CD1b [KO:K06448]
116469248  CD1C; T-cell surface glycoprotein CD1c [KO:K06448]
116469250  CD1D; antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
116469279  [KO:K04513]
116469297  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
116469326  [KO:K06087]
116469373  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
116469612  RAP1A; ras-related protein Rap-1A [KO:K04353]
116469844  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116470322  BVES; blood vessel epicardial substance [KO:K21108]
116470823  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
116470851  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
116471155  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
116471395  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
116471473  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
116471508  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
116471675  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
116471720  SYNPO; synaptopodin [KO:K21112]
116471970  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116472385  GATA4; transcription factor GATA-4 isoform X2 [KO:K09183]
116472488  CLDN23; claudin-23 [KO:K06087]
116472676  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
116472781  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
116473279  CLDN20; claudin-20 [KO:K06087]
116473356  F11R; junctional adhesion molecule A [KO:K06089]
116473372  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X9 [KO:K04851]
116473478  RHOA; transforming protein RhoA [KO:K04513]
116473487  EZR; ezrin isoform X1 [KO:K08007]
116473818  AFDN; afadin isoform X3 [KO:K05702]
116474604  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
116474757  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116475132  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
116475523  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
116475653  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
116476663  CLDN25; LOW QUALITY PROTEIN: putative claudin-25 [KO:K06087]
116476804  DLG3; disks large homolog 3 isoform X3 [KO:K21098]
116476821  [KO:K05756]
116476830  AMOTL1; angiomotin-like protein 1 isoform X3 [KO:K06104]
116476910  RDX; radixin isoform X1 [KO:K05762]
116476925  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
116477185  JAM3; junctional adhesion molecule C [KO:K06785]
116477249  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
116477841  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
116477929  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
116478074  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
116478332  CRB3; protein crumbs homolog 3 isoform X1 [KO:K06090]
116478346  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
116478375  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116478588  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116478633  RAB8A; ras-related protein Rab-8A [KO:K07901]
116479963  CLDN1; claudin-1 [KO:K06087]
116479964  CLDN16; claudin-16 [KO:K06087]
116480008  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
116480242  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
116480287  [KO:K04392]
116480733  ACTN4; alpha-actinin-4 isoform X4 [KO:K05699]
116480850  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
116480923  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
116480924  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
116481235  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
116481240  CLDN11; claudin-11 [KO:K06087]
116481493  [KO:K12757]
116481501  RAB8B; ras-related protein Rab-8B [KO:K07902]
116481760  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
116481786  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
116481894  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
116481932  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
116481973  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
116481977  CLDN8; claudin-8 [KO:K06087]
116482064  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
116482087  [KO:K12751]
116482159  CLDN14; claudin-14 [KO:K06087]
116482165  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
116482444  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
116482510  [KO:K12757]
116482545  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
116482639  CLDN17; claudin-17 [KO:K06087]
116482879  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
116482913  ACTR2; actin-related protein 2 [KO:K17260]
116483166  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
116483317  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
116483336  ACTG1; actin, cytoplasmic 2 [KO:K05692]
116483462  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
116483764  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
116483842  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
116483967  SYMPK; symplekin [KO:K06100]
116484042  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
116485160  PALS1; protein PALS1 isoform X1 [KO:K06091]
116810283  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
116810309  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
116810445  MPP4; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
116810841  ACTB; actin, cytoplasmic 1 [KO:K05692]
116810870  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116810894  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
116810895  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
116810950  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
116810971  CLDN15; claudin-15 isoform X1 [KO:K06087]
116810997  CLDN34; claudin-34 isoform X1 [KO:K06087]
116811050  [KO:K04802]
116811638  CLDN3; claudin-3 [KO:K06087]
116811660  WAS; actin nucleation-promoting factor WAS [KO:K05747]
116811745  MSN; moesin [KO:K05763]
116811931  CLDN2; claudin-2 [KO:K06087]
116811968  AMOT; angiomotin isoform X1 [KO:K16819]
116812042  RAP2C; ras-related protein Rap-2c [KO:K07839]
116812799  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
116813051  CDC42; cell division control protein 42 homolog isoform X2 [KO:K04393]
116813672  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
116814124  CLDN12; claudin-12 [KO:K06087]
116814555  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
116814563  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
hmh04520  Adherens junction
hmh04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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