Homo sapiens (human): 1017
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Entry
1017 CDS
T01001
Symbol
CDK2, CDKN2, p33(CDK2)
Name
(RefSeq) cyclin dependent kinase 2
KO
K02206
cyclin-dependent kinase 2 [EC:
2.7.11.22
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04068
FoxO signaling pathway
hsa04110
Cell cycle
hsa04114
Oocyte meiosis
hsa04115
p53 signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04218
Cellular senescence
hsa04914
Progesterone-mediated oocyte maturation
hsa04934
Cushing syndrome
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05165
Human papillomavirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05200
Pathways in cancer
hsa05203
Viral carcinogenesis
hsa05215
Prostate cancer
hsa05222
Small cell lung cancer
hsa05226
Gastric cancer
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06162
Hepatitis B virus (HBV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06230
Cell cycle (cancer)
nt06261
Gastric cancer
nt06263
Hepatocellular carcinoma
nt06267
Small cell lung cancer
nt06272
Prostate cancer
nt06360
Cushing syndrome
nt06509
DNA replication
Element
N00091
p27-Cell cycle G1/S
N00092
Amplified MYC to p27-cell cycle G1/S
N00093
Loss of CDKN1B to p27-cell cycle G1/S
N00254
CDKN1B-reduced expression to p27-cell cycle G1/S
N00255
Amplified CCNE to cell cycle G1/S
N00264
EBV EBNA3C to p27-Cell cycle G1/S
N00316
Mutation-inactivated CDKN1B to p27-cell cycle G1/S
N00360
HPV E7 to p27-cell cycle G1/S
N00482
EBV EBNA3C to p27-Cell cycle G1/S
N00497
HTLV-1 Tax to p21-cell cycle G1/S
N00498
HTLV-1 Tax to p21-cell cycle G1/S
N00536
MDM2-p21-Cell cycle G1/S
N00537
HBV HBx to cell cycle G1/S
N01468
DNA replication licensing
Drug target
Alvocidib (
DG02041
):
D02880
D09868
Certociclib:
D12946
Dinaciclib:
D09604
Tegtociclib:
D12601
Zotiraciclib (
DG03058
):
D11599
D11600
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
1017 (CDK2)
04151 PI3K-Akt signaling pathway
1017 (CDK2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
1017 (CDK2)
05203 Viral carcinogenesis
1017 (CDK2)
09162 Cancer: specific types
05226 Gastric cancer
1017 (CDK2)
05215 Prostate cancer
1017 (CDK2)
05222 Small cell lung cancer
1017 (CDK2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
1017 (CDK2)
05161 Hepatitis B
1017 (CDK2)
05160 Hepatitis C
1017 (CDK2)
05162 Measles
1017 (CDK2)
05169 Epstein-Barr virus infection
1017 (CDK2)
05165 Human papillomavirus infection
1017 (CDK2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
1017 (CDK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
1017 (CDK2)
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
hsa03032
]
1017 (CDK2)
03036 Chromosome and associated proteins [BR:
hsa03036
]
1017 (CDK2)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.22 cyclin-dependent kinase
1017 (CDK2)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: CMGC group
CDK family
1017 (CDK2)
DNA replication proteins [BR:
hsa03032
]
Eukaryotic type
DNA Replication Initiation Factors
CDK (cyclin dependent kinase)
1017 (CDK2)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Centrosome formation proteins
Kinases and associated factors
1017 (CDK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Haspin_kinase
Kinase-like
Motif
Other DBs
NCBI-GeneID:
1017
NCBI-ProteinID:
NP_001789
OMIM:
116953
HGNC:
1771
Ensembl:
ENSG00000123374
UniProt:
P24941
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:55966830..55972789
Genome browser
AA seq
298 aa
AA seq
DB search
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
NT seq
897 nt
NT seq
+upstream
nt +downstream
nt
atggagaacttccaaaaggtggaaaagatcggagagggcacgtacggagttgtgtacaaa
gccagaaacaagttgacgggagaggtggtggcgcttaagaaaatccgcctggacactgag
actgagggtgtgcccagtactgccatccgagagatctctctgcttaaggagcttaaccat
cctaatattgtcaagctgctggatgtcattcacacagaaaataaactctacctggttttt
gaatttctgcaccaagatctcaagaaattcatggatgcctctgctctcactggcattcct
cttcccctcatcaagagctatctgttccagctgctccagggcctagctttctgccattct
catcgggtcctccaccgagaccttaaacctcagaatctgcttattaacacagagggggcc
atcaagctagcagactttggactagccagagcttttggagtccctgttcgtacttacacc
catgaggtggtgaccctgtggtaccgagctcctgaaatcctcctgggctgcaaatattat
tccacagctgtggacatctggagcctgggctgcatctttgctgagatggtgactcgccgg
gccctattccctggagattctgagattgaccagctcttccggatctttcggactctgggg
accccagatgaggtggtgtggccaggagttacttctatgcctgattacaagccaagtttc
cccaagtgggcccggcaagattttagtaaagttgtacctcccctggatgaagatggacgg
agcttgttatcgcaaatgctgcactacgaccctaacaagcggatttcggccaaggcagcc
ctggctcaccctttcttccaggatgtgaccaagccagtaccccatcttcgactctga
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