KEGG   Homo sapiens (human): 1020
Entry
1020              CDS       T01001                                 
Symbol
CDK5, LIS7, PSSALRE
Name
(RefSeq) cyclin dependent kinase 5
  KO
K02090  cyclin-dependent kinase 5 [EC:2.7.11.22]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
Network
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06541  Cytoskeleton in neurons
  Element
N00997  Mutation-caused aberrant Abeta to electron transfer in Complex I
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01414  Iron to anterograde axonal transport
N01832  NTN1-MAP1B axon guidance signaling
N01835  SEMA3-CRMP2/MAPT axon guidance signaling
N01847  Regulation of dynein-mediated retrograde transport
N01857  SEMA3A-DCX axon guidance signaling
Disease
H00268  Lissencephaly
Drug target
Dinaciclib: D09604
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    1020 (CDK5)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1020 (CDK5)
   05022 Pathways of neurodegeneration - multiple diseases
    1020 (CDK5)
  09165 Substance dependence
   05030 Cocaine addiction
    1020 (CDK5)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1020 (CDK5)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    1020 (CDK5)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     1020 (CDK5)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  CDK family
   1020 (CDK5)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    1020 (CDK5)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Haspin_kinase Seadorna_VP7 Kinase-like APH
Other DBs
NCBI-GeneID: 1020
NCBI-ProteinID: NP_004926
OMIM: 123831
HGNC: 1774
Ensembl: ENSG00000164885
UniProt: Q00535 A0A090N7W4
Structure
LinkDB
Position
7:complement(151053815..151057897)
AA seq 292 aa
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH
KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR
NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS
TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP
MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
NT seq 879 nt   +upstreamnt  +downstreamnt
atgcagaaatacgagaaactggaaaagattggggaaggcacctacggaactgtgttcaag
gccaaaaaccgggagactcatgagatcgtggctctgaaacgggtgaggctggatgacgat
gatgagggtgtgccgagttccgccctccgggagatctgcctactcaaggagctgaagcac
aagaacatcgtcaggcttcatgacgtcctgcacagcgacaagaagctgactttggttttt
gaattctgtgaccaggacctgaagaagtattttgacagttgcaatggtgacctcgatcct
gagattgtaaagtcattcctcttccagctactaaaagggctgggattctgtcatagccgc
aatgtgctacacagggacctgaagccccagaacctgctaataaacaggaatggggagctg
aaattggctgattttggcctggctcgagcctttgggattcccgtccgctgttactcagct
gaggtggtcacactgtggtaccgcccaccggatgtcctctttggggccaagctgtactcc
acgtccatcgacatgtggtcagccggctgcatctttgcagagctggccaatgctgggcgg
cctctttttcccggcaatgatgtcgatgaccagttgaagaggatcttccgactgctgggg
acgcccaccgaggagcagtggccctctatgaccaagctgccagactataagccctatccg
atgtacccggccacaacatccctggtgaacgtcgtgcccaaactcaatgccacagggagg
gatctgctgcagaaccttctgaagtgtaaccctgtccagcgtatctcagcagaagaggcc
ctgcagcacccctacttctccgacttctgtccgccctag

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