KEGG   NETWORK: N01414
Entry
N01414                      Network                                

Name
Iron to anterograde axonal transport
Definition
Fe2+ -> CDK5 -> MAPT -| (TUBA+TUBB)
  Expanded
C14818 -> 1020 -> 4137 -| ((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688))
Class
nt06419 Microtubule-based transport
nt06460 Alzheimer disease
Type
Env factor
Pathway
hsa05010  Alzheimer disease
Disease
H00056  Alzheimer disease
Gene
1020  CDK5; cyclin dependent kinase 5
4137  MAPT; microtubule associated protein tau
7846  TUBA1A; tubulin alpha 1a
10376  TUBA1B; tubulin alpha 1b
84790  TUBA1C; tubulin alpha 1c
7278  TUBA3C; tubulin alpha 3c
113457  TUBA3D; tubulin alpha 3d
112714  TUBA3E; tubulin alpha 3e
7277  TUBA4A; tubulin alpha 4a
51807  TUBA8; tubulin alpha 8
203068  TUBB; tubulin beta class I
81027  TUBB1; tubulin beta 1 class VI
7280  TUBB2A; tubulin beta 2A class IIa
347733  TUBB2B; tubulin beta 2B class IIb
10381  TUBB3; tubulin beta 3 class III
10382  TUBB4A; tubulin beta 4A class IVa
10383  TUBB4B; tubulin beta 4B class IVb
84617  TUBB6; tubulin beta 6 class V
347688  TUBB8; tubulin beta 8 class VIII
Perturbant
C14818 (Fe2+)  Fe2+
Reference
  Authors
Li Y, Jiao Q, Xu H, Du X, Shi L, Jia F, Jiang H
  Title
Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer's Disease.
  Journal
Front Mol Neurosci 10:339 (2017)
DOI:10.3389/fnmol.2017.00339
Reference
  Authors
Wang L, Yin YL, Liu XZ, Shen P, Zheng YG, Lan XR, Lu CB, Wang JZ
  Title
Current understanding of metal ions in the pathogenesis of Alzheimer's disease.
  Journal
Transl Neurodegener 9:10 (2020)
DOI:10.1186/s40035-020-00189-z
Reference
  Authors
Wang ZX, Tan L, Yu JT
  Title
Axonal transport defects in Alzheimer's disease.
  Journal
Mol Neurobiol 51:1309-21 (2015)
DOI:10.1007/s12035-014-8810-x
Reference
  Authors
Guo C, Wang P, Zhong ML, Wang T, Huang XS, Li JY, Wang ZY
  Title
Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain.
  Journal
Neurochem Int 62:165-72 (2013)
DOI:10.1016/j.neuint.2012.12.005
Reference
  Authors
Wang JZ, Wang ZH, Tian Q
  Title
Tau hyperphosphorylation induces apoptotic escape and triggers neurodegeneration in Alzheimer's disease.
  Journal
Neurosci Bull 30:359-66 (2014)
DOI:10.1007/s12264-013-1415-y
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