KEGG   Homo sapiens (human): 142
Entry
142               CDS       T01001                                 
Symbol
PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PARS, PPOL, Poly-PARP, pADPRT-1
Name
(RefSeq) poly(ADP-ribose) polymerase 1
  KO
K24070  poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03410  Base excision repair
hsa04064  NF-kappa B signaling pathway
hsa04210  Apoptosis
hsa04217  Necroptosis
hsa05415  Diabetic cardiomyopathy
Network
nt06504  Base excision repair
  Element
N01434  Base excision and strand cleavage by bifunctional glycosylase
N01435  Base excision and strand cleavage by NEIL glycosylase
Drug target
Iniparib: D09913
Niraparib (DG03120): D10140 D11895<JP/US>
Olaparib: D09730<JP/US>
Pamiparib: D11426
Rucaparib (DG01864): D10079 D10157 D10982<US>
Saruparib: D12981
Talazoparib (DG01865): D10732 D10733<JP/US>
Veliparib: D09692
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    142 (PARP1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    142 (PARP1)
 09160 Human Diseases
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    142 (PARP1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    142 (PARP1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    142 (PARP1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    142 (PARP1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.30  NAD+ ADP-ribosyltransferase
     142 (PARP1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Other termination factors
    142 (PARP1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Centriole proteins
    142 (PARP1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Other BER factors
     142 (PARP1)
SSDB
Motif
Pfam: PARP PARP_reg zf-PARP PADR1_N WGR Zn_ribbon_PADR1 BRCT BRCT_2 ESF1
Other DBs
NCBI-GeneID: 142
NCBI-ProteinID: NP_001609
OMIM: 173870
HGNC: 270
Ensembl: ENSG00000143799
UniProt: P09874
Structure
LinkDB
Position
1:complement(226360691..226408093)
AA seq 1014 aa
MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV
GHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKS
NRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ
LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKA
QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSG
QLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE
TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT
GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSP
WGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE
HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNK
LEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPG
TKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAV
SQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRG
GSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE
REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM
VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSA
NISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
NT seq 3045 nt   +upstreamnt  +downstreamnt
atggcggagtcttcggataagctctatcgagtcgagtacgccaagagcgggcgcgcctct
tgcaagaaatgcagcgagagcatccccaaggactcgctccggatggccatcatggtgcag
tcgcccatgtttgatggaaaagtcccacactggtaccacttctcctgcttctggaaggtg
ggccactccatccggcaccctgacgttgaggtggatgggttctctgagcttcggtgggat
gaccagcagaaagtcaagaagacagcggaagctggaggagtgacaggcaaaggccaggat
ggaattggtagcaaggcagagaagactctgggtgactttgcagcagagtatgccaagtcc
aacagaagtacgtgcaaggggtgtatggagaagatagaaaagggccaggtgcgcctgtcc
aagaagatggtggacccggagaagccacagctaggcatgattgaccgctggtaccatcca
ggctgctttgtcaagaacagggaggagctgggtttccggcccgagtacagtgcgagtcag
ctcaagggcttcagcctccttgctacagaggataaagaagccctgaagaagcagctccca
ggagtcaagagtgaaggaaagagaaaaggcgatgaggtggatggagtggatgaagtggcg
aagaagaaatctaaaaaagaaaaagacaaggatagtaagcttgaaaaagccctaaaggct
cagaacgacctgatctggaacatcaaggacgagctaaagaaagtgtgttcaactaatgac
ctgaaggagctactcatcttcaacaagcagcaagtgccttctggggagtcggcgatcttg
gaccgagtagctgatggcatggtgttcggtgccctccttccctgcgaggaatgctcgggt
cagctggtcttcaagagcgatgcctattactgcactggggacgtcactgcctggaccaag
tgtatggtcaagacacagacacccaaccggaaggagtgggtaaccccaaaggaattccga
gaaatctcttacctcaagaaattgaaggttaaaaaacaggaccgtatattccccccagaa
accagcgcctccgtggcggccacgcctccgccctccacagcctcggctcctgctgctgtg
aactcctctgcttcagcagataagccattatccaacatgaagatcctgactctcgggaag
ctgtcccggaacaaggatgaagtgaaggccatgattgagaaactcggggggaagttgacg
gggacggccaacaaggcttccctgtgcatcagcaccaaaaaggaggtggaaaagatgaat
aagaagatggaggaagtaaaggaagccaacatccgagttgtgtctgaggacttcctccag
gacgtctccgcctccaccaagagccttcaggagttgttcttagcgcacatcttgtcccct
tggggggcagaggtgaaggcagagcctgttgaagttgtggccccaagagggaagtcaggg
gctgcgctctccaaaaaaagcaagggccaggtcaaggaggaaggtatcaacaaatctgaa
aagagaatgaaattaactcttaaaggaggagcagctgtggatcctgattctggactggaa
cactctgcgcatgtcctggagaaaggtgggaaggtcttcagtgccacccttggcctggtg
gacatcgttaaaggaaccaactcctactacaagctgcagcttctggaggacgacaaggaa
aacaggtattggatattcaggtcctggggccgtgtgggtacggtgatcggtagcaacaaa
ctggaacagatgccgtccaaggaggatgccattgagcacttcatgaaattatatgaagaa
aaaaccgggaacgcttggcactccaaaaatttcacgaagtatcccaaaaagttctacccc
ctggagattgactatggccaggatgaagaggcagtgaagaagctgacagtaaatcctggc
accaagtccaagctccccaagccagttcaggacctcatcaagatgatctttgatgtggaa
agtatgaagaaagccatggtggagtatgagatcgaccttcagaagatgcccttggggaag
ctgagcaaaaggcagatccaggccgcatactccatcctcagtgaggtccagcaggcggtg
tctcagggcagcagcgactctcagatcctggatctctcaaatcgcttttacaccctgatc
ccccacgactttgggatgaagaagcctccgctcctgaacaatgcagacagtgtgcaggcc
aaggtggaaatgcttgacaacctgctggacatcgaggtggcctacagtctgctcagggga
gggtctgatgatagcagcaaggatcccatcgatgtcaactatgagaagctcaaaactgac
attaaggtggttgacagagattctgaagaagccgagatcatcaggaagtatgttaagaac
actcatgcaaccacacacaatgcgtatgacttggaagtcatcgatatctttaagatagag
cgtgaaggcgaatgccagcgttacaagccctttaagcagcttcataaccgaagattgctg
tggcacgggtccaggaccaccaactttgctgggatcctgtcccagggtcttcggatagcc
ccgcctgaagcgcccgtgacaggctacatgtttggtaaagggatctatttcgctgacatg
gtctccaagagtgccaactactgccatacgtctcagggagacccaataggcttaatcctg
ttgggagaagttgcccttggaaacatgtatgaactgaagcacgcttcacatatcagcaag
ttacccaagggcaagcacagtgtcaaaggtttgggcaaaactacccctgatccttcagct
aacattagtctggatggtgtagacgttcctcttgggaccgggatttcatctggtgtgaat
gacacctctctactatataacgagtacattgtctatgatattgctcaggtaaatctgaag
tatctgctgaaactgaaattcaattttaagacctccctgtggtaa

KEGG   Homo sapiens (human): 10038
Entry
10038             CDS       T01001                                 
Symbol
PARP2, ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2
Name
(RefSeq) poly(ADP-ribose) polymerase 2
  KO
K28005  poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03410  Base excision repair
hsa04210  Apoptosis
Network
nt06504  Base excision repair
  Element
N01434  Base excision and strand cleavage by bifunctional glycosylase
N01435  Base excision and strand cleavage by NEIL glycosylase
Drug target
Niraparib (DG03120): D10140 D11895<JP/US>
Olaparib: D09730<JP/US>
Pamiparib: D11426
Rucaparib (DG01864): D10079 D10157 D10982<US>
Talazoparib (DG01865): D10732 D10733<JP/US>
Veliparib: D09692
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    10038 (PARP2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    10038 (PARP2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    10038 (PARP2)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    10038 (PARP2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.30  NAD+ ADP-ribosyltransferase
     10038 (PARP2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Other termination factors
    10038 (PARP2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Centriole proteins
    10038 (PARP2)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Other BER factors
     10038 (PARP2)
SSDB
Motif
Pfam: PARP PARP_reg WGR
Other DBs
NCBI-GeneID: 10038
NCBI-ProteinID: NP_005475
OMIM: 607725
HGNC: 272
Ensembl: ENSG00000129484
UniProt: Q9UGN5
Structure
LinkDB
Position
14:20343635..20357904
AA seq 583 aa
MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
NT seq 1752 nt   +upstreamnt  +downstreamnt
atggcggcgcggcggcgacggagcaccggcggcggcagggcgagagcattaaatgaaagc
aaaagagttaataatggcaacacggctccagaagactcttcccctgccaagaaaactcgt
agatgccagagacaggagtcgaaaaagatgcctgtggctggaggaaaagctaataaggac
aggacagaagacaagcaagatggtatgccaggaaggtcatgggccagcaaaagggtctct
gaatctgtgaaggccttgctgttaaagggcaaagctcctgtggacccagagtgtacagcc
aaggtggggaaggctcatgtgtattgtgaaggaaatgatgtctatgatgtcatgctaaat
cagaccaatctccagttcaacaacaacaagtactatctgattcagctattagaagatgat
gcccagaggaacttcagtgtttggatgagatggggccgagttgggaaaatgggacagcac
agcctggtggcttgttcaggcaatctcaacaaggccaaggaaatctttcagaagaaattc
cttgacaaaacgaaaaacaattgggaagatcgagaaaagtttgagaaggtgcctggaaaa
tatgatatgctacagatggactatgccaccaatactcaggatgaagaggaaacaaagaaa
gaggaatctcttaaatctcccttgaagccagagtcacagctagatcttcgggtacaggag
ttaataaagttgatctgtaatgttcaggccatggaagaaatgatgatggaaatgaagtat
aataccaagaaagccccacttgggaagctgacagtggcacaaatcaaggcaggttaccag
tctcttaagaagattgaggattgtattcgggctggccagcatggacgagctctcatggaa
gcatgcaatgaattctacaccaggattccgcatgactttggactccgtactcctccacta
atccggacacagaaggaactgtcagaaaaaatacaattactagaggctttgggagacatt
gaaattgctattaagctggtgaaaacagagctacaaagcccagaacacccattggaccaa
cactatagaaacctacattgtgccttgcgcccccttgaccatgaaagttatgagttcaaa
gtgatttcccagtacctacaatctacccatgctcccacacacagcgactataccatgacc
ttgctggatttgtttgaagtggagaaggatggtgagaaagaagccttcagagaggacctt
cataacaggatgcttctatggcatggttccaggatgagtaactgggtgggaatcttgagc
catgggcttcgaattgccccacctgaagctcccatcacaggttacatgtttgggaaagga
atctactttgctgacatgtcttccaagagtgccaattactgctttgcctctcgcctaaag
aatacaggactgctgctcttatcagaggtagctctaggtcagtgtaatgaactactagag
gccaatcctaaggccgaaggattgcttcaaggtaaacatagcaccaaggggctgggcaag
atggctcccagttctgcccacttcgtcaccctgaatgggagtacagtgccattaggacca
gcaagtgacacaggaattctgaatccagatggttataccctcaactacaatgaatatatt
gtatataaccccaaccaggtccgtatgcggtaccttttaaaggttcagtttaatttcctt
cagctgtggtga

KEGG   Homo sapiens (human): 8505
Entry
8505              CDS       T01001                                 
Symbol
PARG, PARG99
Name
(RefSeq) poly(ADP-ribose) glycohydrolase
  KO
K07759  poly(ADP-ribose) glycohydrolase [EC:3.2.1.143]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03410  Base excision repair
Network
nt06504  Base excision repair
  Element
N01434  Base excision and strand cleavage by bifunctional glycosylase
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    8505 (PARG)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.143  poly(ADP-ribose) glycohydrolase
     8505 (PARG)
SSDB
Motif
Pfam: PARG_cat_C PARG_cat_N
Other DBs
NCBI-GeneID: 8505
NCBI-ProteinID: NP_003622
OMIM: 603501
HGNC: 8605
Ensembl: ENSG00000227345
UniProt: Q86W56
Structure
LinkDB
Position
10:complement(49818279..49942027)
AA seq 976 aa
MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPG
RAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQ
HNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPE
QFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKS
CDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEP
ESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTK
GGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKA
EDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANH
TVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQ
TALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKI
ALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDIN
FNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHV
TYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNEC
LIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEK
MRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYF
TFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAV
ESCAETADHSGQRTGT
NT seq 2931 nt   +upstreamnt  +downstreamnt
atgaatgcgggccccggctgtgaaccctgcaccaagcgaccccgctggggcgccgctaca
acttcgccggctgcttcggacgcccggagctttcccagcaggcagaggcgcgtcctcgac
cccaaggacgctcacgtgcagttcagggtcccaccgtcctcgccagcctgcgtcccaggg
cgggcgggacagcacagaggcagcgccacctcgcttgttttcaaacaaaagactattacc
agttggatggacactaaaggaatcaagacagcggaatcagaaagtttggatagtaaagaa
aacaacaatacaagaatagaatccatgatgagttctgtacaaaaagataacttttaccaa
cataatgtagaaaaattagaaaatgtttctcagctaagtcttgataagtcacccactgaa
aaaagtacacagtatttgaaccagcatcagactgcagcaatgtgtaagtggcaaaatgaa
gggaaacacacggagcagcttttggaaagtgaacctcaaacagtaaccctggtaccagag
cagtttagtaatgctaacattgatcggtcacctcaaaatgatgatcacagtgacacagat
agtgaagagaatagagacaatcaacagtttctcacaactgtaaagcttgcaaatgcaaag
cagactacagaagatgaacaggccagagaagccaaaagccaccagaagtgcagcaagtct
tgcgatcctggggaagactgtgcaagttgtcagcaagatgagatagatgtggtgccagag
agtccattgtcagatgttggctctgaggatgttggtactgggccaaaaaatgacaacaaa
ttgactagacaagaaagttgcctaggaaattctcctccatttgagaaggaaagtgaaccc
gagtcaccgatggatgtggataattctaaaaatagttgtcaagactcagaagcagatgag
gagacaagtccaggttttgatgaacaagaagatggtagttcctcccaaacagcaaataaa
ccttcaaggttccaagcaagagacgctgacattgaatttaggaaacggtactctactaag
ggcggtgaagttagattacatttccaatttgaaggaggagagagtcgcactggaatgaat
gatttaaatgctaaactacctggaaatatttctagcctgaatgtagaatgcagaaattct
aagcaacatggaaaaaaggattctaaaatcacagatcatttcatgagactgcccaaagca
gaggacagaagaaaagaacagtgggaaaccaaacatcaaagaacagaaaggaagatccct
aaatacgttccacctcacctttctccagataagaagtggcttggaactcccattgaggag
atgagaagaatgcctcggtgtgggatccggctgcctctcttgagaccatctgccaatcac
acagtaactattcgggtagatcttttgcgagcaggagaagttcctaaaccttttccaaca
cattataaagatttgtgggataacaagcatgttaaaatgccttgttcagaacaaaatttg
tacccagtggaagatgagaatggtgagcgaactgcggggagccggtgggagctcattcag
actgcacttctcaacaaatttacacgaccccaaaacttgaaggatgctattctgaaatac
aatgtggcatattctaagaaatgggactttacagctttgatcgatttctgggataaggta
cttgaagaagcagaagctcaacatttatatcagtccatcttgcctgatatggtgaaaatt
gcactctgtctgccaaatatttgcacccagccaataccactcctgaaacagaagatgaat
cattccatcacaatgtcgcaggaacagattgccagtcttttagctaatgctttcttctgc
acatttccacgacgaaatgctaagatgaaatcggagtattctagttacccagacattaac
ttcaatcgattgtttgagggacgttcatcaaggaaaccggagaaacttaaaacgctcttc
tgctactttagaagagtcacagagaaaaaacctactgggttggtgacatttacaagacag
agtcttgaagattttccagaatgggaaagatgtgaaaaacccttgacacgattgcatgtc
acttacgaaggtaccatagaagaaaatggccaaggcatgctacaggtggattttgcaaat
cgttttgttggaggtggtgtaaccagtgcaggacttgtgcaagaagaaatccgcttttta
atcaatcctgagttgattatttcacggctcttcactgaggtgctggatcacaatgaatgt
ctaattatcacaggtactgagcagtacagtgaatacacaggctatgctgagacatatcgt
tggtcccggagccacgaagatgggagtgaaagggacgactggcagcggcgctgcactgag
atcgttgccatcgatgctcttcacttcagacgctacctcgatcagtttgtgcctgagaaa
atgagacgcgagctgaacaaggcttactgtggatttctccgtcctggagtttcttcagag
aatctttctgcagtggccacaggaaactggggctgtggtgcctttgggggtgatgccagg
ttaaaagccttaatacagatattggcagctgctgcagctgagcgagatgtggtttatttc
acctttggggactcagaattgatgagagacatttacagcatgcacattttccttactgaa
aggaaactcactgttggagatgtgtataagctgttgctacgatactacaatgaagaatgc
agaaactgttccacccctggaccagacatcaagctttatccattcatataccatgctgtc
gagtcctgtgcagagaccgctgaccattcagggcaaaggacagggacctga

KEGG   Homo sapiens (human): 54936
Entry
54936             CDS       T01001                                 
Symbol
ADPRS, ADPRHL2, ARH3, CONDSIAS
Name
(RefSeq) ADP-ribosylserine hydrolase
  KO
K11687  poly(ADP-ribose) glycohydrolase ARH3 [EC:3.2.1.143]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03410  Base excision repair
Network
nt06504  Base excision repair
  Element
N01434  Base excision and strand cleavage by bifunctional glycosylase
Disease
H02572  Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    54936 (ADPRS)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.143  poly(ADP-ribose) glycohydrolase
     54936 (ADPRS)
SSDB
Motif
Pfam: ADP_ribosyl_GH FUSC_2
Other DBs
NCBI-GeneID: 54936
NCBI-ProteinID: NP_060295
OMIM: 610624
HGNC: 21304
Ensembl: ENSG00000116863
UniProt: Q9NX46
Structure
LinkDB
Position
1:36088892..36093932
AA seq 363 aa
MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHDTVDLTSVLRHVQSLEP
DPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGV
VTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQL
THASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDARELGMEER
PYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNS
LQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVF
QKS
NT seq 1092 nt   +upstreamnt  +downstreamnt
atggccgcagcggcgatggcggcagcggcaggtggaggggctggcgcggcccgctccctc
tcgcgcttccgaggctgcctggctggcgcgctgctcggggactgcgtgggctccttctac
gaggcccacgacaccgtcgacctgacgtcagtcctgcgtcatgtccagagtctggagccg
gaccccggcacgcccgggagtgagcggacagaagccttgtactacacagatgacacagcc
atggccagggccctggtgcagtccctgctagccaaggaggcctttgacgaggtggacatg
gctcacagatttgctcaggagtacaagaaagaccctgacaggggctatggtgctggagta
gtcactgtcttcaagaagctcctgaaccccaaatgtcgcgatgtctttgagcctgcccgg
gcccagtttaacgggaaaggctcctatggcaatggaggtgccatgcgggtggctggcatc
tccctggcctatagcagtgtccaggatgtgcagaagtttgcccggctctcggcccagctg
acacacgcctcctccctgggttacaatggcgccatcctgcaggccctggctgtgcacctg
gccttgcagggcgagtcttccagcgagcactttctcaagcaactcctgggccacatggag
gatctggagggtgatgcccagtccgtcttggatgccagggagttgggcatggaggagcgt
ccatactccagccgcctgaagaagattggagagcttctagaccaggcatcggtgaccagg
gaggaagtggtgtctgagctagggaatggcattgctgcctttgagtcggtacccaccgcc
atctactgcttcctacgctgcatggagccagaccctgagatcccttctgccttcaatagc
ctccaaaggactctcatttattccatctcacttggtggggacacagacaccattgccacc
atggctggggccattgctggtgcctactatgggatggatcaggtgccagagagctggcag
caaagctgtgaaggctacgaggagacagacatcctggcccaaagcctgcaccgtgtcttc
cagaagagttga

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