KEGG   Homo sapiens (human): 1962
Entry
1962              CDS       T01001                                 
Symbol
EHHADH, ECHD, FRTS3, L-PBE, LBFP, LBP, MFE1, PBFE
Name
(RefSeq) enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
  KO
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00071  Fatty acid degradation
hsa00280  Valine, leucine and isoleucine degradation
hsa00310  Lysine degradation
hsa00380  Tryptophan metabolism
hsa00410  beta-Alanine metabolism
hsa00640  Propanoate metabolism
hsa00650  Butanoate metabolism
hsa01100  Metabolic pathways
hsa01212  Fatty acid metabolism
hsa03320  PPAR signaling pathway
hsa04146  Peroxisome
Module
hsa_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
hsa_M00087  beta-Oxidation
Disease
H01198  Fanconi renotubular syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    1962 (EHHADH)
   00650 Butanoate metabolism
    1962 (EHHADH)
  09103 Lipid metabolism
   00071 Fatty acid degradation
    1962 (EHHADH)
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    1962 (EHHADH)
   00310 Lysine degradation
    1962 (EHHADH)
   00380 Tryptophan metabolism
    1962 (EHHADH)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    1962 (EHHADH)
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    1962 (EHHADH)
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    1962 (EHHADH)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     1962 (EHHADH)
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17  enoyl-CoA hydratase
     1962 (EHHADH)
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.8  Delta3-Delta2-enoyl-CoA isomerase
     1962 (EHHADH)
SSDB
Motif
Pfam: 3HCDH_N ECH_1 3HCDH ECH_2 UDPG_MGDP_dh_N NAD_binding_2 Peptidase_S49 TrkA_N 2-Hacid_dh_C ApbA F420_oxidored
Other DBs
NCBI-GeneID: 1962
NCBI-ProteinID: NP_001957
OMIM: 607037
HGNC: 3247
Ensembl: ENSG00000113790
UniProt: Q08426
LinkDB
Position
3:complement(185190624..185254049)
AA seq 723 aa
MAEYTRLHNALALIRLRNPPVNAISTTLLRDIKEGLQKAVIDHTIKAIVICGAEGKFSAG
ADIRGFSAPRTFGLTLGHVVDEIQRNEKPVVAAIQGMAFGGGLELALGCHYRIAHAEAQV
GLPEVTLGLLPGARGTQLLPRLTGVPAALDLITSGRRILADEALKLGILDKVVNSDPVEE
AIRFAQRVSDQPLESRRLCNKPIQSLPNMDSIFSEALLKMRRQHPGCLAQEACVRAVQAA
VQYPYEVGIKKEEELFLYLLQSGQARALQYAFFAERKANKWSTPSGASWKTASARPVSSV
GVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASKMQQSGHPWSG
PKPRLTSSVKELGGVDLVIEAVFEEMSLKKQVFAELSAVCKPEAFLCTNTSALDVDEIAS
STDRPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVMNLSKKIKKIGVVVGNCFGFV
GNRMLNPYYNQAYFLLEEGSKPEEVDQVLEEFGFKMGPFRVSDLAGLDVGWKSRKGQGLT
GPTLLPGTPARKRGNRRYCPIPDVLCELGRFGQKTGKGWYQYDKPLGRIHKPDPWLSKFL
SRYRKTHHIEPRTISQDEILERCLYSLINEAFRILGEGIAASPEHIDVVYLHGYGWPRHK
GGPMFYASTVGLPTVLEKLQKYYRQNPDIPQLEPSDYLKKLASQGNPPLKEWQSLAGSPS
SKL
NT seq 2172 nt   +upstreamnt  +downstreamnt
atggccgagtatacgcggctgcacaacgccttggcgctaatccgcctccgaaacccgccg
gtcaacgcgatcagtacgactttactccgtgacataaaagaaggactacagaaagctgta
atagaccatacaataaaagccattgtgatttgtggagcagagggcaaattttctgcaggt
gctgatattcgtggcttcagtgctcctaggacatttggccttacactgggacatgtagta
gatgaaatacagagaaatgagaagcccgtggtggcagcaatccaaggcatggctttcgga
gggggactagagctggccctgggctgtcactataggattgcccacgcagaggctcaagtt
ggcttaccagaagttacactgggacttctccctggtgcaagaggaacccagcttctcccc
agactcactggagttcctgctgcacttgacttaattacctcaggaagacgtattttagca
gatgaagcactcaagctgggcattctagataaagttgtaaactcagacccggttgaagaa
gcaatcagatttgctcagagagtttcagatcaacctctagaatcccgtagactctgcaac
aagccaattcagagcttgcccaacatggacagcatttttagtgaggccctcttgaagatg
cggaggcagcaccctgggtgtcttgcacaggaggcttgtgtccgtgcagtccaggctgct
gtgcagtatccctatgaagtgggcatcaagaaggaggaggagctgtttctatatcttttg
caatcagggcaggctagagccctgcaatatgctttcttcgctgaaaggaaagcaaataag
tggtcaactccctccggagcatcgtggaaaacagcatcagcgcggcctgtctcctcagtt
ggtgttgttggcttgggaacaatgggccgaggcattgtcatttcttttgcaagggccagg
attcctgtgattgctgtagactcggacaaaaaccagctagcaactgcaaacaagatgata
acctctgtcttggaaaaagaagcctccaaaatgcaacagagcggccacccttggtcagga
ccaaaacccaggttaacttcatctgtgaaggagcttggtggtgtagatttagtcattgaa
gcagtatttgaggaaatgagcctgaagaagcaggtctttgctgaactctcagctgtgtgc
aaaccagaagcatttttgtgcactaatacttcagccctggatgttgatgagattgcttct
tccactgatcgtcctcacttggtcattggcacccacttcttttcgccagctcatgtcatg
aagttgttagaggttattcccagccaatactcttcccccactaccattgccactgttatg
aacttatcaaaaaagattaaaaagattggagtcgttgtaggcaactgttttggatttgtg
gggaatcgaatgttgaatccttactacaatcaggcatatttcttgttagaagaaggcagc
aaaccagaggaggtagatcaggtgctggaagagtttggttttaaaatgggaccttttaga
gtgtctgatcttgctgggttggatgtgggctggaaatctagaaaggggcaaggtcttact
ggacctacattgcttccaggaactcctgcccgaaaaaggggtaataggaggtactgccca
attcctgatgtgctctgtgaattaggacgatttggccagaagacaggtaagggttggtat
caatatgacaagccattgggtaggattcacaaacctgatccctggctttccaaattccta
tcacggtatagaaaaacccatcacattgaaccacgtaccattagccaggatgagatcctt
gaacgctgcttatattcacttatcaatgaagcattccgtatcttgggagaagggatagct
gctagcccagagcacattgatgttgtctatttacatggatatggatggccaaggcacaag
ggcgggcccatgttctatgcttccacagttgggttgcccacagttctagagaaattgcag
aaatattacaggcagaaccctgatattccccaactggagccaagtgactatctaaaaaaa
ctggcttctcagggaaaccctcccctgaaagaatggcaaagcttggcaggctcccctagc
agtaaattgtga

KEGG   Homo sapiens (human): 3028
Entry
3028              CDS       T01001                                 
Symbol
HSD17B10, 17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, HSD10MD, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1
Name
(RefSeq) hydroxysteroid 17-beta dehydrogenase 10
  KO
K08683  3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00280  Valine, leucine and isoleucine degradation
hsa01100  Metabolic pathways
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06024  Valine, leucine and isoleucine degradation
  Element
N00856  Isoleucine degradation
Disease
H00925  2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    3028 (HSD17B10)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3028 (HSD17B10)
   05022 Pathways of neurodegeneration - multiple diseases
    3028 (HSD17B10)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    3028 (HSD17B10)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3028 (HSD17B10)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     3028 (HSD17B10)
    1.1.1.178  3-hydroxy-2-methylbutyryl-CoA dehydrogenase
     3028 (HSD17B10)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial transcription and translation factors
   Mitochondrial ribonuclease P
    3028 (HSD17B10)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   3028 (HSD17B10)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR Epimerase
Other DBs
NCBI-GeneID: 3028
NCBI-ProteinID: NP_004484
OMIM: 300256
HGNC: 4800
Ensembl: ENSG00000072506
UniProt: Q99714 A0A0S2Z410
Structure
LinkDB
Position
X:complement(53431258..53434376)
AA seq 261 aa
MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF
APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV
NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL
PIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAI
IENPFLNGEVIRLDGAIRMQP
NT seq 786 nt   +upstreamnt  +downstreamnt
atggcagcagcgtgtcggagcgtgaagggcctggtggcggtaataaccggaggagcctcg
ggcctgggcctggccacggcggagcgacttgtggggcagggagcctctgctgtgcttctg
gacctgcccaactcgggtggggaggcccaagccaagaagttaggaaacaactgcgttttc
gccccagccgacgtgacctctgagaaggatgtgcaaacagctctggctctagcaaaagga
aagtttggccgtgtggatgtagctgtcaactgtgcaggcatcgcggtggctagcaagacg
tacaacttaaagaagggccagacccataccttggaagacttccagcgagttcttgatgtg
aatctcatgggcaccttcaatgtgatccgcctggtggctggtgagatgggccagaatgaa
ccagaccagggaggccaacgtggggtcatcatcaacactgccagtgtggctgccttcgag
ggtcaggttggacaagctgcatactctgcttccaaggggggaatagtgggcatgacactg
cccattgctcgggatctggctcccataggtatccgggtgatgaccattgccccaggtctg
tttggcaccccactgctgaccagcctcccagagaaagtgtgcaacttcttggccagccaa
gtgcccttccctagccgactgggtgaccctgctgagtatgctcacctcgtacaggccatc
atcgagaacccattcctcaatggagaggtcatccggctggatggggccattcgtatgcag
ccttga

KEGG   Homo sapiens (human): 3033
Entry
3033              CDS       T01001                                 
Symbol
HADH, HAD, HADH1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD
Name
(RefSeq) hydroxyacyl-CoA dehydrogenase
  KO
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00062  Fatty acid elongation
hsa00071  Fatty acid degradation
hsa00280  Valine, leucine and isoleucine degradation
hsa00310  Lysine degradation
hsa00380  Tryptophan metabolism
hsa00650  Butanoate metabolism
hsa01100  Metabolic pathways
hsa01212  Fatty acid metabolism
Module
hsa_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
hsa_M00085  Fatty acid elongation in mitochondria
hsa_M00087  beta-Oxidation
Network
nt06020  beta-Oxidation in mitochondria
nt06024  Valine, leucine and isoleucine degradation
  Element
N00804  beta-Oxidation
N00856  Isoleucine degradation
Disease
H00525  Disorders of mitochondrial fatty-acid oxidation
H01267  Familial hyperinsulinemic hypoglycemia
H01364  3-Hydroxyacyl-CoA dehydrogenase deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    3033 (HADH)
  09103 Lipid metabolism
   00062 Fatty acid elongation
    3033 (HADH)
   00071 Fatty acid degradation
    3033 (HADH)
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    3033 (HADH)
   00310 Lysine degradation
    3033 (HADH)
   00380 Tryptophan metabolism
    3033 (HADH)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     3033 (HADH)
SSDB
Motif
Pfam: 3HCDH_N 3HCDH Pyr_redox_2 UDPG_MGDP_dh_N DAO Pyr_redox NAD_Gly3P_dh_N NAD_binding_2 NAD_binding_8 AlaDh_PNT_C F420_oxidored 2-Hacid_dh_C NAD_binding_7 HI0933_like Sacchrp_dh_NADP TrkA_N GIDA FAD_binding_3 XdhC_C
Other DBs
NCBI-GeneID: 3033
NCBI-ProteinID: NP_005318
OMIM: 601609
HGNC: 4799
Ensembl: ENSG00000138796
UniProt: Q16836 A0A140VK76
Structure
LinkDB
Position
4:107989889..108035171
AA seq 314 aa
MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTE
DILAKSKKGIEESLRKVAKKKFAENLKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAI
VENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKL
VEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERGDAS
KEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAEN
KFGKKTGEGFYKYK
NT seq 945 nt   +upstreamnt  +downstreamnt
atggccttcgtcaccaggcagttcatgcgttccgtgtcctcctcgtccaccgcctcggcc
tcggccaagaagataatcgtcaagcacgtgacggtcatcggcggcgggctgatgggcgcc
ggcattgcccaggttgctgcagcaactggtcacacagtagtgttggtagaccagacagag
gacatcctggcaaaatccaaaaagggaattgaggaaagccttaggaaagtggcaaagaag
aagtttgcagaaaaccttaaggccggcgatgaatttgtggagaagaccctgagcaccata
gcgaccagcacggatgcagcctccgttgtccacagcacagacttggtggtggaagccatc
gtggagaatctgaaggtgaaaaacgagctcttcaaaaggctggacaagtttgctgctgaa
catacaatctttgccagcaacacttcctccttgcagattacaagcatagctaatgccacc
accagacaagaccgattcgctggcctccatttcttcaacccagtgcctgtcatgaaactt
gtggaggtcattaaaacaccaatgaccagccagaagacatttgaatctttggtagacttt
agcaaagccctaggaaagcatcctgtttcttgcaaggacactcctgggtttattgtgaac
cgcctcctggttccatacctcatggaagcaatcaggctgtatgaacgaggtgacgcatcc
aaagaagacattgacactgctatgaaattaggagccggttaccccatgggcccatttgag
cttctagattatgtcggactggatactacgaagttcatcgtggatgggtggcatgaaatg
gatgcagagaacccattacatcagcccagcccatccttaaataagctggtagcagagaac
aagttcggcaagaagactggagaaggattttacaaatacaagtga

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