KEGG   Homo sapiens (human): 2145
Entry
2145              CDS       T01001                                 
Symbol
EZH1, KMT6B
Name
(RefSeq) enhancer of zeste 1 polycomb repressive complex 2 subunit
  KO
K17451  [histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00310  Lysine degradation
hsa01100  Metabolic pathways
hsa03083  Polycomb repressive complex
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Drug target
Valemetostat (DG03075): D11551 D11662<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    2145 (EZH1)
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    2145 (EZH1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    2145 (EZH1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.356  [histone H3]-lysine27 N-trimethyltransferase
     2145 (EZH1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     2145 (EZH1)
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.1
     2145 (EZH1)
    PRC2.2
     2145 (EZH1)
SSDB
Motif
Pfam: Ezh2_MCSS PRC2_HTH_1 SET EZH2_WD-Binding preSET_CXC Myb_DNA-binding
Other DBs
NCBI-GeneID: 2145
NCBI-ProteinID: NP_001982
OMIM: 601674
HGNC: 3526
Ensembl: ENSG00000108799
UniProt: Q92800
Structure
LinkDB
Position
17:complement(42700275..42745040)
AA seq 747 aa
MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAI
ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
RRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
EELFFDYRYSQADALKYVGIERETDVL
NT seq 2244 nt   +upstreamnt  +downstreamnt
atggaaataccaaatccccctacctccaaatgtatcacttactggaaaagaaaagtgaaa
tctgaatacatgcgacttcgacaacttaaacggcttcaggcaaatatgggtgcaaaggct
ttgtatgtggcaaattttgcaaaggttcaagaaaaaacccagatcctcaatgaagaatgg
aagaagcttcgtgtccaacctgttcagtcaatgaagcctgtgagtggacacccttttctc
aaaaagtgtaccatagagagcattttcccgggatttgcaagccaacatatgttaatgagg
tcactgaacacagttgcattggttcccatcatgtattcctggtcccctctccaacagaac
tttatggtagaagatgagacggttttgtgcaatattccctacatgggagatgaagtgaaa
gaagaagatgagacttttattgaggagctgatcaataactatgatgggaaagtccatggt
gaagaagagatgatccctggatccgttctgattagtgatgctgtttttctggagttggtc
gatgccctgaatcagtactcagatgaggaggaggaagggcacaatgacacctcagatgga
aagcaggatgacagcaaagaagatctgccagtaacaagaaagagaaagcgacatgctatt
gaaggcaacaaaaagagttccaagaaacagttcccaaatgacatgatcttcagtgcaatt
gcctcaatgttccctgagaatggtgtcccagatgacatgaaggagaggtatcgagaacta
acagagatgtcagaccccaatgcacttccccctcagtgcacacccaacatcgatggcccc
aatgccaagtctgtgcagcgggagcaatctctgcactccttccacacacttttttgccgg
cgctgctttaaatacgactgcttccttcacccttttcatgccacccctaatgtatataaa
cgcaagaataaagaaatcaagattgaaccagaaccatgtggcacagactgcttccttttg
ctggaaggagcaaaggagtatgccatgctccacaacccccgctccaagtgctctggtcgt
cgccggagaaggcaccacatagtcagtgcttcctgctccaatgcctcagcctctgctgtg
gctgagactaaagaaggagacagtgacagggacacaggcaatgactgggcctccagttct
tcagaggctaactctcgctgtcagactcccacaaaacagaaggctagtccagccccacct
caactctgcgtagtggaagcaccctcggagcctgtggaatggactggggctgaagaatct
ctttttcgagtcttccatggcacctacttcaacaacttctgttcaatagccaggcttctg
gggaccaagacgtgcaagcaggtctttcagtttgcagtcaaagaatcacttatcctgaag
ctgccaacagatgagctcatgaacccctcacagaagaagaaaagaaagcacagattgtgg
gctgcacactgcaggaagattcagctgaagaaagataactcttccacacaagtgtacaac
taccaaccctgcgaccacccagaccgcccctgtgacagcacctgcccctgcatcatgact
cagaatttctgtgagaagttctgccagtgcaacccagactgtcagaatcgtttccctggc
tgtcgctgtaagacccagtgcaataccaagcaatgtccttgctatctggcagtgcgagaa
tgtgaccctgacctgtgtctcacctgtggggcctcagagcactgggactgcaaggtggtt
tcctgtaaaaactgcagcatccagcgtggacttaagaagcacctgctgctggccccctct
gatgtggccggatggggcaccttcataaaggagtctgtgcagaagaacgaattcatttct
gaatactgtggtgagctcatctctcaggatgaggctgatcgacgcggaaaggtctatgac
aaatacatgtccagcttcctcttcaacctcaataatgattttgtagtggatgctactcgg
aaaggaaacaaaattcgatttgcaaatcattcagtgaatcccaactgttatgccaaagtg
gtcatggtgaatggagaccatcggattgggatctttgccaagagggcaattcaagctggc
gaagagctcttctttgattacaggtacagccaagctgatgctctcaagtacgtggggatc
gagagggagaccgacgtcctttag

KEGG   Homo sapiens (human): 2146
Entry
2146              CDS       T01001                                 
Symbol
EZH2, ENX-1, ENX1, EZH2b, KMT6, KMT6A, WVS, WVS2
Name
(RefSeq) enhancer of zeste 2 polycomb repressive complex 2 subunit
  KO
K11430  [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00310  Lysine degradation
hsa01100  Metabolic pathways
hsa03083  Polycomb repressive complex
hsa05206  MicroRNAs in cancer
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Disease
H01613  Follicular lymphoma
H01751  Weaver syndrome
H02410  Myelodysplastic/myeloproliferative neoplasms
H02411  Chronic myelomonocytic leukemia
H02412  Atypical chronic myeloid leukemia
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Drug target
Mevrometostat: D12845
Tazemetostat (DG03020): D11444 D11485<JP/US>
Tulmimetostat: D12602
Valemetostat (DG03075): D11551 D11662<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    2146 (EZH2)
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    2146 (EZH2)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    2146 (EZH2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    2146 (EZH2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.356  [histone H3]-lysine27 N-trimethyltransferase
     2146 (EZH2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     2146 (EZH2)
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.1
     2146 (EZH2)
    PRC2.2
     2146 (EZH2)
SSDB
Motif
Pfam: Ezh2_MCSS PRC2_HTH_1 SET EZH2_WD-Binding preSET_CXC
Other DBs
NCBI-GeneID: 2146
NCBI-ProteinID: NP_001190176
OMIM: 601573
HGNC: 3527
Ensembl: ENSG00000106462
UniProt: Q15910
Structure
LinkDB
Position
7:complement(148807383..148884291)
AA seq 746 aa
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH
ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN
NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM
KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA
PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ
NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS
CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK
YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE
ELFFDYRYSQADALKYVGIEREMEIP
NT seq 2241 nt   +upstreamnt  +downstreamnt
atgggccagactgggaagaaatctgagaagggaccagtttgttggcggaagcgtgtaaaa
tcagagtacatgcgactgagacagctcaagaggttcagacgagctgatgaagtaaagagt
atgtttagttccaatcgtcagaaaattttggaaagaacggaaatcttaaaccaagaatgg
aaacagcgaaggatacagcctgtgcacatcctgacttctgtgagctcattgcgcgggact
agggagtgttcggtgaccagtgacttggattttccaacacaagtcatcccattaaagact
ctgaatgcagttgcttcagtacccataatgtattcttggtctcccctacagcagaatttt
atggtggaagatgaaactgttttacataacattccttatatgggagatgaagttttagat
caggatggtactttcattgaagaactaataaaaaattatgatgggaaagtacacggggat
agagaatgtgggtttataaatgatgaaatttttgtggagttggtgaatgcccttggtcaa
tataatgatgatgacgatgatgatgatggagacgatcctgaagaaagagaagaaaagcag
aaagatctggaggatcaccgagatgataaagaaagccgcccacctcggaaatttccttct
gataaaatttttgaagccatttcctcaatgtttccagataagggcacagcagaagaacta
aaggaaaaatataaagaactcaccgaacagcagctcccaggcgcacttcctcctgaatgt
acccccaacatagatggaccaaatgctaaatctgttcagagagagcaaagcttacactcc
tttcatacgcttttctgtaggcgatgttttaaatatgactgcttcctacatccttttcat
gcaacacccaacacttataagcggaagaacacagaaacagctctagacaacaaaccttgt
ggaccacagtgttaccagcatttggagggagcaaaggagtttgctgctgctctcaccgct
gagcggataaagaccccaccaaaacgtccaggaggccgcagaagaggacggcttcccaat
aacagtagcaggcccagcacccccaccattaatgtgctggaatcaaaggatacagacagt
gatagggaagcagggactgaaacggggggagagaacaatgataaagaagaagaagagaag
aaagatgaaacttcgagctcctctgaagcaaattctcggtgtcaaacaccaataaagatg
aagccaaatattgaacctcctgagaatgtggagtggagtggtgctgaagcctcaatgttt
agagtcctcattggcacttactatgacaatttctgtgccattgctaggttaattgggacc
aaaacatgtagacaggtgtatgagtttagagtcaaagaatctagcatcatagctccagct
cccgctgaggatgtggatactcctccaaggaaaaagaagaggaaacaccggttgtgggct
gcacactgcagaaagatacagctgaaaaaggacggctcctctaaccatgtttacaactat
caaccctgtgatcatccacggcagccttgtgacagttcgtgcccttgtgtgatagcacaa
aatttttgtgaaaagttttgtcaatgtagttcagagtgtcaaaaccgctttccgggatgc
cgctgcaaagcacagtgcaacaccaagcagtgcccgtgctacctggctgtccgagagtgt
gaccctgacctctgtcttacttgtggagccgctgaccattgggacagtaaaaatgtgtcc
tgcaagaactgcagtattcagcggggctccaaaaagcatctattgctggcaccatctgac
gtggcaggctgggggatttttatcaaagatcctgtgcagaaaaatgaattcatctcagaa
tactgtggagagattatttctcaagatgaagctgacagaagagggaaagtgtatgataaa
tacatgtgcagctttctgttcaacttgaacaatgattttgtggtggatgcaacccgcaag
ggtaacaaaattcgttttgcaaatcattcggtaaatccaaactgctatgcaaaagttatg
atggttaacggtgatcacaggataggtatttttgccaagagagccatccagactggcgaa
gagctgttttttgattacagatacagccaggctgatgccctgaagtatgtcggcatcgaa
agagaaatggaaatcccttga

KEGG   Homo sapiens (human): 23512
Entry
23512             CDS       T01001                                 
Symbol
SUZ12, CHET9, IMMAS, JJAZ1
Name
(RefSeq) SUZ12 polycomb repressive complex 2 subunit
  KO
K11463  polycomb protein SUZ12
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Disease
H02522  Imagawa-Matsumoto syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    23512 (SUZ12)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    23512 (SUZ12)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.1
     23512 (SUZ12)
    PRC2.2
     23512 (SUZ12)
SSDB
Motif
Pfam: VEFS-Box Zn_SUZ12 DUF2070 Chorion_3
Other DBs
NCBI-GeneID: 23512
NCBI-ProteinID: NP_056170
OMIM: 606245
HGNC: 17101
Ensembl: ENSG00000178691
UniProt: Q15022
Structure
LinkDB
Position
17:31937007..32001038
AA seq 739 aa
MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSA
AAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSH
RNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQN
SVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPS
NSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMT
VFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLR
WTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPN
ENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVY
HPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASM
SEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQI
EEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHL
VSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEK
ALETDSVSGVSKQSKKQKL
NT seq 2220 nt   +upstreamnt  +downstreamnt
atggcgcctcagaagcacggcggtgggggagggggcggctcggggcccagcgcggggtcc
gggggaggcggcttcgggggttcggcggcggtggcggcggcgacggcttcgggcggcaaa
tccggcggcgggagctgtggagggggtggcagttactcggcctcctcctcctcctccgcg
gcggcagcggcgggggctgcggtgttaccggtgaagaagccgaaaatggagcacgtccag
gctgaccacgagcttttcctccaggcctttgagaagccaacacagatctatagatttctt
cgaactcggaatctcatagcaccaatatttttgcacagaactcttacttacatgtctcat
cgaaactccagaacaaacatcaaaaggaaaacatttaaagttgatgatatgttatcaaaa
gtagagaaaatgaaaggagagcaagaatctcatagcttgtcagctcatttgcagcttacg
tttactggtttcttccacaaaaatgataagccatcaccaaactcagaaaatgaacaaaat
tctgttaccctggaagtcctgcttgtgaaagtttgccacaaaaaaagaaaggatgtaagt
tgtccaataaggcaagttcccacaggtaaaaagcaggtgcctttgaatcctgacctcaat
caaacaaaacccggaaatttcccgtcccttgcagtttccagtaatgaatttgaacctagt
aacagccatatggtgaagtcttactcgttgctatttagagtgactcgtccaggaagaaga
gagtttaatggaatgattaatggagaaaccaatgaaaatattgatgtcaatgaagagctt
ccagccagaagaaaacgaaatcgtgaggatggggaaaagacatttgttgcacaaatgaca
gtatttgataaaaacaggcgcttacagcttttagatggggaatatgaagtagccatgcag
gaaatggaagaatgtccaataagcaagaaaagagcaacatgggagactattcttgatggg
aagaggctgcctccattcgaaacattttctcagggacctacgttgcagttcactcttcgt
tggacaggagagaccaatgataaatctacggctcctattgccaaacctcttgccactaga
aattcagagagtctccatcaggaaaacaagcctggttcagttaaacctactcaaactatt
gctgttaaagaatcattgactacagatctacaaacaagaaaagaaaaggatactccaaat
gaaaaccgacaaaaattaagaatattttatcagtttctctataacaacaatacaaggcaa
caaactgaagcaagagatgacctgcattgcccttggtgtactctgaactgccgcaaactt
tatagtttactcaagcatcttaaactctgccatagcagatttatcttcaactatgtttat
catccaaaaggtgctaggatagatgtttctatcaatgagtgttatgatggctcctatgca
ggaaatcctcaggatattcatcgccaacctggatttgcttttagtcgcaacggaccagtt
aagagaacacctatcacacatattcttgtgtgcaggccaaaacgaacaaaagcaagcatg
tctgaatttcttgaatctgaagatggggaagtagaacagcaaagaacatatagtagtggc
cacaatcgtctgtatttccatagtgatacctgcttacctctccgtccacaagaaatggaa
gtagatagtgaagatgaaaaggatcctgaatggctaagagaaaaaaccattacacaaatt
gaagagttttctgatgttaatgaaggagagaaagaagtgatgaaactctggaatctccat
gtcatgaagcatgggtttattgctgacaatcaaatgaatcatgcctgtatgctgtttgta
gaaaattatggacagaaaataattaagaagaatttatgtcgaaacttcatgcttcatcta
gtcagcatgcatgactttaatcttattagcataatgtcaatagataaagctgttaccaag
ctccgtgaaatgcagcaaaaattagaaaagggggaatctgcttcccctgcaaacgaagaa
ataactgaagaacaaaatgggacagcaaatggatttagtgaaattaactcaaaagagaaa
gctttggaaacagatagtgtctcaggggtttcaaaacagagcaaaaaacaaaaactctga

KEGG   Homo sapiens (human): 8726
Entry
8726              CDS       T01001                                 
Symbol
EED, COGIS, HEED, WAIT1
Name
(RefSeq) embryonic ectoderm development
  KO
K11462  polycomb protein EED
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Disease
H02477  Cohen-Gibson syndrome
Drug target
Pociredir: D12782
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    8726 (EED)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    8726 (EED)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.1
     8726 (EED)
    PRC2.2
     8726 (EED)
SSDB
Motif
Pfam: WD40_WDHD1_1st WD40_CDC20-Fz WD40 WD40_Prp19 Beta-prop_EML_2 WDR55 Beta-prop_TEP1_2nd EIF3I Beta-prop_EML Beta-prop_WDR19_1st WD40_RFWD3 Beta-prop_CAF1B_HIR1 Beta-prop_TEP1_C Beta-prop_EIPR1 Beta-prop_WDR75_1st WD_LRWD1 WD40_MABP1-WDR62_2nd Beta-prop_RIG_2nd Beta-prop_DCAF4 Beta-prop_Nup120_160 Beta-prop_WDR90_POC16_2nd NBCH_WD40
Other DBs
NCBI-GeneID: 8726
NCBI-ProteinID: NP_003788
OMIM: 605984
HGNC: 3188
Ensembl: ENSG00000074266
UniProt: O75530
Structure
LinkDB
Position
11:86244753..86287615
AA seq 441 aa
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
NT seq 1326 nt   +upstreamnt  +downstreamnt
atgtccgagagggaagtgtcgactgcgccggcgggaacagacatgcctgcggccaagaag
cagaagctgagcagtgacgagaacagcaatccagacctctctggagacgagaatgatgac
gctgtcagtatagaaagtggtacaaacactgaacgccctgatacacctacaaacacgcca
aatgcacctggaaggaaaagttggggaaagggaaaatggaagtcaaagaaatgcaaatat
tctttcaaatgtgtaaatagtctcaaggaagatcataaccaaccattgtttggagttcag
tttaactggcacagtaaagaaggagatccattagtgtttgcaactgtaggaagcaacaga
gttaccttgtatgaatgtcattcacaaggagaaatccggttgttgcaatcttacgtggat
gctgatgctgatgaaaacttttacacttgtgcatggacctatgatagcaatacgagccat
cctctgctggctgtagctggatctagaggcataattaggataataaatcctataacaatg
cagtgtataaagcactatgttggccatggaaatgctatcaatgagctgaaattccatcca
agagatccaaatcttctcctgtcagtaagtaaagatcatgctttacgattatggaatatc
cagacggacactctggtggcaatatttggaggcgtagaagggcacagagatgaagttcta
agtgctgattatgatcttttgggtgaaaaaataatgtcctgtggtatggatcattctctt
aaactttggaggatcaattcaaagagaatgatgaatgcaattaaggaatcttatgattat
aatccaaataaaactaacaggccatttatttctcagaaaatccattttcctgatttttct
accagagacatacataggaattatgttgattgtgtgcgatggttaggcgatttgatactt
tctaagtcttgtgaaaatgccattgtgtgctggaaacctggcaagatggaagatgatata
gataaaattaaacccagtgaatctaatgtgactattcttgggcgatttgattacagccag
tgtgacatttggtacatgaggttttctatggatttctggcaaaagatgcttgcattgggc
aatcaagttggcaaactttatgtttgggatttagaagtagaagatcctcataaagccaaa
tgtacaacactgactcatcataaatgtggtgctgctattcgacaaaccagttttagcagg
gatagcagcattcttatagctgtttgtgatgatgccagtatttggcgctgggatcgactt
cgataa

KEGG   Homo sapiens (human): 5931
Entry
5931              CDS       T01001                                 
Symbol
RBBP7, RbAp46, SPGFX9
Name
(RefSeq) RB binding protein 7, chromatin remodeling factor
  KO
K11659  histone-binding protein RBBP7
Organism
hsa  Homo sapiens (human)
Pathway
hsa03082  ATP-dependent chromatin remodeling
hsa03083  Polycomb repressive complex
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Disease
H01282  Spermatogenic failure
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03082 ATP-dependent chromatin remodeling
    5931 (RBBP7)
   03083 Polycomb repressive complex
    5931 (RBBP7)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    5931 (RBBP7)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HDAC complexes
    Sin3A-HDAC complex
     5931 (RBBP7)
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.1
     5931 (RBBP7)
    PRC2.2
     5931 (RBBP7)
  Chromatin remodeling factors
   NuRD complex
    5931 (RBBP7)
   NuRF complex
    5931 (RBBP7)
SSDB
Motif
Pfam: WD40 WD40_CDC20-Fz CAF1C_H4-bd WD40_Prp19 Beta-prop_CAF1B_HIR1 Beta-prop_RIG_2nd Beta-prop_EIPR1 Beta-prop_TEP1_2nd WDR55 Beta-prop_EML_2 WD40_WDHD1_1st EIF3I Beta-prop_EML Beta-prop_WDR75_1st WD40_MABP1-WDR62_2nd Beta-prop_WDR90_POC16_2nd Beta-prop_RIG_1st WD40_RFWD3 Beta-prop_WDR19_1st WD_LRWD1 ANAPC4_WD40 Beta-prop_DCAF12 WD40_MABP1-WDR62_1st eIF2A Beta-prop_SPT8 MIOS_WD40 Beta-prop_IFT122_1st NBCH_WD40 Beta-prop_DCAF4
Other DBs
NCBI-GeneID: 5931
NCBI-ProteinID: NP_002884
OMIM: 300825
HGNC: 9890
Ensembl: ENSG00000102054
UniProt: Q16576 Q6FHQ0
Structure
LinkDB
Position
X:complement(16844341..16870362)
AA seq 425 aa
MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDY
ALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKI
NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY
GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES
LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW
DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED
GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSEL
EGQGS
NT seq 1278 nt   +upstreamnt  +downstreamnt
atggcgagtaaagagatgtttgaagatactgtggaggagcgtgtcatcaatgaagaatat
aaaatctggaagaagaatacaccgtttctatatgacctggttatgacccatgctcttcag
tggcccagtcttaccgttcagtggcttcctgaagtgactaaacctgaaggaaaagattat
gcccttcattggctagtgctggggactcatacgtctgatgagcagaatcatctggtggtt
gctcgagtacatattcccaatgatgatgcacagtttgatgcttcccattgtgacagtgac
aagggtgaatttggtggctttggttctgtaacaggaaaaattgaatgtgaaattaaaatc
aatcacgaaggagaagtaaaccgtgctcgttacatgccgcagaatcctcacatcattgct
acaaaaacaccatcttctgatgtgttggtttttgactatacaaaacaccctgctaaacca
gacccaagtggagaatgtaatcctgatctcagattaagaggtcaccagaaggaaggctat
ggtctctcctggaattcaaatttgagtggacatctcctaagtgcatctgatgaccatact
gtttgtctgtgggatataaacgcaggaccaaaagaaggcaaaattgtggatgctaaagcc
atctttactggccactcagctgttgtagaggatgtggcctggcacctgctgcacgagtca
ttgtttggatctgttgctgatgatcagaaacttatgatatgggacaccaggtccaatacc
acctccaagccgagtcacttggtggatgcgcacactgccgaagtcaactgcctctcattc
aatccctacagcgaatttattctagccaccggctctgcggataagaccgtagctttatgg
gatctgcgtaacttaaaattaaaactccataccttcgaatctcataaagatgaaattttc
caggtccactggtctccacataatgaaactattctggcttcaagtggtactgaccgccgc
ctgaatgtgtgggatttaagtaaaattggggaagaacaatcagcagaagatgcagaagat
gggcctccagaactcctgtttattcatggaggacacactgctaagatttcagattttagc
tggaaccccaatgagccttgggtcatttgctcagtgtctgaggataacatcatgcagata
tggcaaatggctgaaaatatttacaatgatgaagagtcagatgtcacgacatccgaactg
gagggacaaggatcttaa

KEGG   Homo sapiens (human): 5928
Entry
5928              CDS       T01001                                 
Symbol
RBBP4, NURF55, RBAP48, lin-53
Name
(RefSeq) RB binding protein 4, chromatin remodeling factor
  KO
K10752  histone-binding protein RBBP4
Organism
hsa  Homo sapiens (human)
Pathway
hsa03082  ATP-dependent chromatin remodeling
hsa03083  Polycomb repressive complex
hsa04218  Cellular senescence
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03082 ATP-dependent chromatin remodeling
    5928 (RBBP4)
   03083 Polycomb repressive complex
    5928 (RBBP4)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    5928 (RBBP4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    5928 (RBBP4)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Nucleosome assembly factors
   Histone chaperones
    CAF-1
     5928 (RBBP4)
  Histone modification proteins
   HAT complexes
    HATB complex
     5928 (RBBP4)
   HDAC complexes
    Sin3A-HDAC complex
     5928 (RBBP4)
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.1
     5928 (RBBP4)
    PRC2.2
     5928 (RBBP4)
  Centromeric chromatin formation proteins
   Kinetochore proteins
    MIS16-MIS18 complex
     5928 (RBBP4)
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    5928 (RBBP4)
  Chromatin remodeling factors
   NuRD complex
    5928 (RBBP4)
   NuRF complex
    5928 (RBBP4)
   NuRF complex (fruit fly)
    5928 (RBBP4)
SSDB
Motif
Pfam: WD40 CAF1C_H4-bd WD40_CDC20-Fz WD40_Prp19 Beta-prop_CAF1B_HIR1 Beta-prop_RIG_2nd Beta-prop_EIPR1 Beta-prop_TEP1_2nd WDR55 Beta-prop_EML_2 WD40_WDHD1_1st Beta-prop_WDR75_1st Beta-prop_EML EIF3I WD40_MABP1-WDR62_2nd WD_LRWD1 Beta-prop_WDR90_POC16_2nd Beta-prop_WDR19_1st WD40_RFWD3 ANAPC4_WD40 Beta-prop_DCAF12 WD40_MABP1-WDR62_1st Beta-prop_RIG_1st eIF2A MIOS_WD40 Beta-prop_SPT8 NBCH_WD40 Beta-prop_IFT140_1st Beta-prop_IFT122_1st Beta-prop_DCAF4
Other DBs
NCBI-GeneID: 5928
NCBI-ProteinID: NP_005601
OMIM: 602923
HGNC: 9887
Ensembl: ENSG00000162521
UniProt: Q09028
Structure
LinkDB
Position
1:32651208..32686211
AA seq 425 aa
MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD
FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK
INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG
YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE
SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL
WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE
DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP
EGQGS
NT seq 1278 nt   +upstreamnt  +downstreamnt
atggccgacaaggaagcagccttcgacgacgcagtggaagaacgagtgatcaacgaggaa
tacaaaatatggaaaaagaacaccccttttctttatgatttggtgatgacccatgctctg
gagtggcccagcctaactgcccagtggcttccagatgtaaccagaccagaagggaaagat
ttcagcattcatcgacttgtcctggggacacacacatcggatgaacaaaaccatcttgtt
atagccagtgtgcagctccctaatgatgatgctcagtttgatgcgtcacactacgacagt
gagaaaggagaatttggaggttttggttcagttagtggaaaaattgaaatagaaatcaag
atcaaccatgaaggagaagtaaacagggcccgttatatgccccagaacccttgtatcatc
gcaacaaagactccttccagtgatgttcttgtttttgactatacaaaacatccttctaaa
ccagatccttctggagagtgcaacccagacttgcgtctccgtggacatcagaaggaaggc
tatgggctttcttggaacccaaatctcagtgggcacttacttagtgcttcagatgaccat
accatctgcctgtgggacatcagtgccgttccaaaggagggaaaagtggtagatgcgaag
accatctttacagggcatacggcagtagtagaagatgtttcctggcatctactccatgag
tctctgtttgggtcagttgctgatgatcagaaacttatgatttgggatactcgttcaaac
aatacttccaaaccaagccactcagttgatgctcacactgctgaagtgaactgcctttct
ttcaatccttatagtgagttcattcttgccacaggatcagctgacaagactgttgccttg
tgggatctgagaaatctgaaacttaagttgcattcctttgagtcacataaggatgaaata
ttccaggttcagtggtcacctcacaatgagactattttagcttccagtggtactgatcgc
agactgaatgtctgggatttaagtaaaattggagaggaacaatccccagaagatgcagaa
gacgggccaccagagttgttgtttattcatggtggtcatactgccaagatatctgatttc
tcctggaatcccaatgaaccttgggtgatttgttctgtatcagaagacaatatcatgcaa
gtgtggcaaatggcagagaacatttataatgatgaagaccctgaaggaagcgtggatcca
gaaggacaagggtcctag

KEGG   Homo sapiens (human): 121536
Entry
121536            CDS       T01001                                 
Symbol
AEBP2
Name
(RefSeq) AE binding protein 2
  KO
K17452  zinc finger protein AEBP2
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    121536 (AEBP2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    121536 (AEBP2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    121536 (AEBP2)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys2His2 others
    121536 (AEBP2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.2
     121536 (AEBP2)
SSDB
Motif
Pfam: zf-C2H2 zf-C2H2_4 zf-H2C2_2 Zap1_zf1
Other DBs
NCBI-GeneID: 121536
NCBI-ProteinID: NP_001107648
OMIM: 617934
HGNC: 24051
Ensembl: ENSG00000139154
UniProt: Q6ZN18
Structure
LinkDB
Position
12:19404072..19522227
AA seq 517 aa
MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLN
GGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEES
SAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSV
VSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGR
STPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWK
GCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSK
VSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIE
SLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKL
PKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ
NT seq 1554 nt   +upstreamnt  +downstreamnt
atggccgccgctatcaccgacatggccgacctggaggagctctcccgcctgagccctctg
ccccccggcagcccgggttcggcggcgcggggccgggctgagccccccgaggaggaggag
gaagaggaggaggaggaagaggaggcggaggccgaggcggtggcggcgctgctgctgaac
ggcggcagcggtgggggcggcggaggcggcggcggaggagtggggggcggcgaggcagag
acgatgtcggagccgagccccgagagcgccagccaggccggggaggacgaagacgaggag
gaggacgacgaggaggaggaagatgagagcagcagcagcggcgggggtgaggaggagagt
agcgccgagagcctggtgggcagcagcggcgggagcagcagcgacgagacccgctcgttg
agccccggcgccgccagcagcagcagcggggatggggacggcaaggagggcctggaggag
cccaagggaccgcggggcagccagggcggcggcgggggcggcagcagtagcagcagcgta
gtctccagcggcggcgacgagggctacgggactgggggaggcggaagcagcgcgacctcc
gggggccggcggggcagcttggagatgtcgtcggatggggaacccctgagccgcatggac
tcggaggacagcataagcagtactataatggatgtagacagcacaatttccagtgggcgt
tcaactccagcaatgatgaatggacaaggaagcactacttcttcaagcaaaaatattgcc
tataattgttgttgggaccagtgccaggcttgcttcaactctagcccagatctggcagat
cacatccgttccatacatgtagatggtcagcgaggaggggtatttgtttgcttatggaaa
ggttgtaaagtatataacactccatctaccagtcaaagttggttacaaaggcatatgctg
acacacagtggagacaaacctttcaagtgtgttgttggtggctgcaatgccagctttgct
tctcagggagggctagctcgtcatgtacccacacacttcagtcagcagaactcctcaaaa
gtttctagccagccaaaggccaaagaagaatctccttctaaagctggaatgaacaaaagg
aggaaattaaagaacaaaagacgacgctcattaccacggccacatgatttcttcgatgca
caaacactggatgcgataagacatcgagccatatgctttaacctctcagctcatatagaa
agtttagggaagggacacagtgttgtttttcatagtactgtaatagctaagagaaaagaa
gattctgggaagatcaaacttttgcttcattggatgcctgaagacattctgcctgatgtg
tgggtgaatgaaagtgaacgacatcagttaaaaactaaagtagttcatttatcaaagcta
cccaaagatactgccttgcttttggacccaaacatatacagaacaatgccgcagaagagg
ttgaagagaactctgataagaaaagtgttcaatttgtatttaagcaaacagtga

KEGG   Homo sapiens (human): 3720
Entry
3720              CDS       T01001                                 
Symbol
JARID2, DIDDF, JMJ
Name
(RefSeq) jumonji and AT-rich interaction domain containing 2
  KO
K11478  protein Jumonji
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
hsa04550  Signaling pathways regulating pluripotency of stem cells
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Disease
H02618  Developmental delay with variable intellectual disability and dysmorphic facies
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    3720 (JARID2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    3720 (JARID2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    3720 (JARID2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    3720 (JARID2)
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.2
     3720 (JARID2)
SSDB
Motif
Pfam: JmjC ARID JmjN zf-C5HC2
Other DBs
NCBI-GeneID: 3720
NCBI-ProteinID: NP_004964
OMIM: 601594
HGNC: 6196
Ensembl: ENSG00000008083
UniProt: Q92833
Structure
LinkDB
Position
6:15246069..15522042
AA seq 1246 aa
MSKERPKRNIIQKKYDDSDGIPWSEERVVRKVLYLSLKEFKNSQKRQHAEGIAGSLKTVN
GLLGNDQSKGLGPASEQSENEKDDASQVSSTSNDVSSSDFEEGPSRKRPRLQAQRKFAQS
QPNSPSTTPVKIVEPLLPPPATQISDLSKRKPKTEDFLTFLCLRGSPALPNSMVYFGSSQ
DEEEVEEEDDETEDVKTATNNASSSCQSTPRKGKTHKHVHNGHVFNGSSRSTREKEPVQK
HKSKEATPAKEKHSDHRADSRREQASANHPAAAPSTGSSAKGLAATHHHPPLHRSAQDLR
KQVSKVNGVTRMSSLGAGVTSAKKMREVRPSPSKTVKYTATVTKGAVTYTKAKRELVKDT
KPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASKSTGPAVNGLKVSGRLNPKSCTK
EVGGRQLREGLQLREGLRNSKRRLEEAHQAEKPQSPPKKMKGAAGPAEGPGKKAPAERGL
LNGHVKKEVPERSLERNRPKRATAGKSTPGRQAHGKADSASCENRSTSQPESVHKPQDSG
KAEKGGGKAGWAAMDEIPVLRPSAKEFHDPLIYIESVRAQVEKFGMCRVIPPPDWRPECK
LNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLKSQGITMDELPLIGGCELDLACFFR
LINEMGGMQQVTDLKKWNKLADMLRIPRTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLE
KEVLMEKEILEKRKGPLEGHTENDHHKFHPLPRFEPKNGLIHGVAPRNGFRSKLKEVGQA
QLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMSMCFSKE
PAPAEIEQEYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTG
SILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYIDYLHTGADCIWYCIPAEEENKL
EDVVHTLLQANGTPGLQMLESNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVC
CGYSVSETVHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLST
ISALLDELRDTELRQRRQLFEAGLHSSARYGSHDGSSTVADGKKKPRKWLQLETSERRCQ
ICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQIISLVNQICGKV
SGKNGSIENCLSKPTPKRGPRKRATVDVPPSRLSASSSSKSASSSS
NT seq 3741 nt   +upstreamnt  +downstreamnt
atgagcaaggaaagacccaagaggaatatcattcagaagaaatacgatgacagtgatggg
attccgtggtcagaagaacgggtggtacgtaaagtcctttatttgtctctgaaggagttc
aagaattcccagaagaggcagcatgcggaaggcattgctgggagcctgaaaactgtgaat
gggctccttggtaatgaccagtctaagggattaggaccagcatcagaacagtcagagaat
gaaaaggacgatgcatcccaagtgtcctccactagcaacgatgttagttcttcagatttt
gaagaagggccgtcgaggaaaaggcccaggctgcaagcacaaaggaagtttgctcagtct
cagccgaatagtcccagcacaactccagtaaagatagtggagccattgctaccccctcca
gctactcagatatcagacctctctaaaaggaagcctaagacagaagattttcttaccttt
ctctgccttcgaggttctcctgcgctgcccaacagcatggtgtattttggaagctctcag
gatgaggaggaagtcgaggaggaagatgatgagacagaagacgtcaaaacagccaccaac
aatgcttcatcttcatgccagtcgacccccaggaaaggaaaaacccacaaacatgttcac
aacgggcatgttttcaatggttccagcaggtcaacacgggagaaggaacctgttcaaaaa
cacaaaagcaaagaggccactcccgcaaaggagaagcacagcgatcaccgggctgacagc
cgccgggagcaggcttcagctaaccaccccgcagcggccccctccacgggttcctcggcc
aaggggcttgctgccacccatcaccacccccctctgcatcggtcggctcaggacttacgg
aaacaggtttctaaggtaaacggagtcactcgaatgtcatctctgggtgcaggtgtaacc
agtgccaaaaagatgcgcgaggtcagaccttcaccatccaaaactgtgaagtacactgcc
acggtgacgaagggggctgtcacatacaccaaagccaagagagaactggtcaaggacacc
aaacccaatcaccacaagcccagttccgctgtcaaccacacaatctcagggaaaactgaa
agtagcaatgcaaaaacccgcaaacaggtgctatccctcgggggggcgtccaagtccact
gggcccgccgtcaatggcctcaaggtcagtggcaggttgaacccaaagtcatgcactaag
gaggtgggggggcggcagctgcgggagggcctgcagctgcgggaggggctgcggaactcc
aagaggagactggaagaggcacaccaggcggagaagccgcagtcgccccccaagaagatg
aaaggggcggctggccccgccgaaggccctggcaagaaggccccggccgagagaggtctg
ctgaacggacacgtgaagaaggaagtgccggagcgcagtctggagaggaatcggccgaag
cgggccacggccgggaagagcacgccaggcagacaagcacatggcaaggcggacagcgcc
tcctgtgaaaatcgttctacctcgcaaccggagtccgtgcacaagccgcaggactcgggc
aaggccgagaagggcggcggcaaggccgggtgggcggccatggacgagatccccgtcctc
aggccctccgccaaggagttccacgatccgctcatctacatcgagtcggtccgcgctcag
gtggagaagttcgggatgtgcagggtgatcccccctccggactggcggcccgagtgcaag
ctcaacgatgagatgcggtttgtcacgcagattcagcacatccacaagctgggccggcgc
tggggccccaacgtgcagcggctggcctgcatcaagaagcacctcaaatctcagggcatc
accatggacgagctcccgctcatagggggctgtgagctcgacctggcctgctttttccgg
ctgattaatgagatgggcggcatgcagcaagtgactgacctcaaaaaatggaacaaacta
gcagacatgctgcgcatccccagaactgcccaggaccggctggccaagctgcaggaggcc
tactgccagtacctactctcctacgactccctgtccccagaggagcaccggcggctggag
aaggaggtgctgatggagaaggagatcctggagaagcgcaaggggccgctggaaggccac
acagagaacgaccaccacaagttccaccctctgccccgcttcgagcccaagaatgggctc
atccacggcgtggcccccaggaacggcttccgcagcaagctcaaggaggtgggccaggcc
cagttgaagactggccggcggcgactcttcgctcaggaaaaagaagtggtcaaggaagag
gaggaggacaaaggcgtcctcaatgacttccacaagtgcatctataagggaaggtctgtt
tctctaacaactttttatcgaacagcgaggaatatcatgagcatgtgtttcagcaaggag
cctgccccagccgaaatcgagcaagagtactggaggctagtggaagagaaggactgccac
gtggcagtgcactgcggcaaggtggacaccaacactcacggcagtggattcccagtagga
aaatcagaacccttttcgaggcatggatggaacctcaccgtcctccccaataacacaggg
tccatcctgcgtcacctcggtgctgtgcctggagtgactattccctggctaaatattggc
atggtcttttctacctcatgctggtctcgagaccaaaatcaccttccatacattgactac
ttacacactggtgctgactgcatttggtattgcattcctgctgaggaggagaacaagctg
gaagatgtggtccacaccctgctgcaagccaatggcaccccagggctgcagatgctggaa
agcaacgtcatgatctccccggaggtgctgtgcaaagaggggatcaaggtgcacaggacc
gtgcagcagagtggccagtttgtcgtctgcttcccgggatcctttgtgtccaaagtgtgc
tgtgggtacagcgtgtctgaaaccgtgcactttgctaccacccagtggacaagtatgggc
tttgagaccgccaaggaaatgaagcgtcgccatatagctaagccattctccatggagaag
ttactctaccagattgcacaagcagaagcaaaaaaagaaaacggtcccactctcagtacc
atctcagccctcctggatgagctcagggatacagagctgcggcagcgcaggcagctgttc
gaggctggcctccactcctccgcacgctatggcagccacgatggcagcagcacggtggcg
gacgggaagaaaaagcctcgaaagtggctgcagttggagacgtcagagaggaggtgtcag
atctgccagcacctgtgctacctgtccatggtggtacaagagaacgaaaacgtcgtgttc
tgtctggagtgtgctctgcgccacgtggagaaacagaagtcctgccgagggctgaagttg
atgtaccgctacgatgaggaacagattatcagtctggtcaatcagatctgcggcaaagtg
tctggtaaaaacggcagcattgagaactgtctcagtaaacccacaccaaaaagaggtccc
cgcaagagagcgacagtggacgtgcccccctcccgtctgtcagcctccagttcatccaaa
agtgcttcgagctcatcatga

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